Rchr

J-GLOBAL ID：200901059796088187 Update date: Jan. 17, 2024

Yamasaki Kazuo

ヤマサキカズオ | Yamasaki Kazuo

Affiliation and department：
Job title： Assistant Professor

Research field (2)： Functional biochemistry , Biophysics

Research keywords (30)：カルシウムポンプ , 筋小胞体 , 部位特異的変異 , リン酸化中間体 , Ca^<2+>輸送 , 静電的相互作用 , P-type ATPase , エネルギー共役 , SERCA1a , 酵素反応速度論 , 生体エネルギー転換 , 生体エネルギー変換 , カルシウムイオン , チロシン , プロテアソーム , ATP結合部位 , 疎水的相互作用 , テトラニトロメタン , イオン輸送 , SERCAla , COS-1 , Nanodisc , 酵素速度反応論 , 酵素反応 , 機能構造連関 , FDNP-ATP , 小胞体 , カルシウムATPアーゼ , Ca^<2+>ポンプ , Ca2+-ATPase

Research theme for competitive and other funds (2)：

筋小胞体カルシウムポンプの分子機構の研究
Study on Molecular Mechanism of Calcium Pump of Sarcoplasmic Reticulum

Papers (25)：

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MISC (13)：

Multiple and Distinct Effects of Mutations of Tyr122, Glu123, Arg324, and Arg334 Involved in Interactions between the Top Part of Second and Fourth Transmembrane Helices in Sarcoplasmic Reticulum Ca2+-ATPase: CHANGES IN CYTOPLASMIC DOMAIN ORGANIZATION ・・・. Journal of Biological Chemistry. 2004. in press
ADP-insensitive phosphoenzyme intermediate of sarcoplasmic reticulum Ca²⁺-ATPase has a compact comformation resistant to proteinase K, V8 protease and trypsin(jointly worked). FEBS Letter. 2001. 489. 2/3. 277-282
Mutations of arginin-198 in sarcoplasmic reticulum Ca²⁺-ATPase cause inhibition of hydrolysis of the phosphoenzyme intermediate formed from inorganic phosphate(jointly worked). "Na/K-ATPase and Related ATPases"Elsevier Science B.V.(Netherland). 2000. 297-300
T Daiho, K Yamasaki, H Suzuki, T Saino, T Kanazawa. Deletions or specific substitutions of a few residues in the NH2-terminal region (Ala(3) to Thr(9)) of sarcoplasmic reticulum Ca2+-ATPase cause inactivation and rapid degradation of the enzyme expressed in COS-1 cells. JOURNAL OF BIOLOGICAL CHEMISTRY. 1999. 274. 34. 23910-23915
Mutations of Arg¹⁹⁸ in sarcoplasmic reticulum Ca²⁺-ATPase Cause Inactivation and Rapid Degradation of the Enzyme Expressed in COS-1 Cells(jointly worked). FEBS Letter. 1999. 444. 54-58

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Books (2)：

Only half of the Ca<sup>2+</sup>-ATPase molecules present in sarcoplasmic reticulum vesicles can be phosphorylated with ATP or inorganic phosphate(jointly worked)
"Na/K-ATPase and Related ATPases"Elsevier Science B.V.(Netherland) 2000
Deletion on specific substitutions of a few residues in the NH<sub>2</sub>-terminal Ala3-Thr9 region of sarcoplasmic reticulum Ca<sup>2+</sup>-ATPase cause inactivation and rapid degradation of the enzyme expressed in COS-1 cells(jointly worked)
"Na/K-ATPase and Related ATPases"Elsevier Science B.V.(Netherland) 2000

Lectures and oral presentations (14)：

筋小胞体カルシウムポンプのナノディスクへの組み込みとその性質
(日本生化学会大会プログラム・講演要旨集 2013)
筋小胞体Ca2+-ATPaseのE1P-E2P転換とCa2+放出の共役機構
(日本生化学会大会プログラム・講演要旨集 2012)
筋小胞体Ca2+-ATPaseのリン酸化中間体転換過程における静電的相互作用の役割
(日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 2010)
筋小胞体Ca2+-ATPaseのE1P-E2P転換とCa2+輸送の共役におけるK+の役割
(日本生化学会大会プログラム・講演要旨集 2009)
筋小胞体Ca2+-ATPaseのCa2+放出過程におけるTyr122-Hydrophobic clusterとK+との関連
(日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 2007)

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Education (4)：

- 1992 Osaka University
- 1992 Osaka University Graduate School, Division of Natural Science
- 1987 Osaka University School of Science
- 1987 Osaka University Faculty of Science

Professional career (2)：

(BLANK) (Osaka University)
(BLANK) (Osaka University)

Work history (1)：

2015 - Asahikawa Medical University School of Medicine

Association Membership(s) (1)：

日本生化学会

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