Hirotune Shinji

ヒロツネシンジ | Hirotune Shinji

Affiliation and department：
Job title： Professor

Research field (1)： Medical biochemistry

Research keywords (7)： intracellular transport , neural development , neuronal degeneration , 神経科学発生生物学 , Diseace , Development , Neuren

Research theme for competitive and other funds (9)：

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Papers (46)：

Shiori Toba, Mingyue Jin, Masami Yamada, Kanako Kumamoto, Sakiko Matsumoto, Takuo Yasunaga, Yuko Fukunaga, Atsuo Miyazawa, Sakiko Fujita, Kyoko Itoh, et al. Alpha-synuclein facilitates to form short unconventional microtubules that have a unique function in the axonal transport. Scientific Reports. 2018. 7. 1. 16386
広常真治. シヌクレイン変異によるパーキンソン病の分子機構解明. (公財)上原記念生命科学財団上原記念生命科学財団研究報告集. 2017. 31. 1-5
Kanako Kumamoto, Tokuichi Iguchi, Ryuichi Ishida, Takuya Uemura, Makoto Sato, Shinji Hirotsune. Developmental downregulation of LIS1 expression limits axonal extension and allows axon pruning. Biology Open. 2017. 6. 7. 1041-1055
Mingyue Jin, Oz Pomp, Tomoyasu Shinoda, Shiori Toba, Takayuki Torisawa, Kenya Furuta, Kazuhiro Oiwa, Takuo Yasunaga, Daiju Kitagawa, Shigeru Matsumura, et al. Katanin p80, NuMA and cytoplasmic dynein cooperate to control microtubule dynamics. Scientific Reports. 2017. 7. 39902
Hironori Inaba, Hidemasa Goto, Kousuke Kasahara, Kanako Kumamoto, Shigenobu Yonemura, Akihito Inoko, Shotaro Yamano, Hideki Wanibuchi, Dongwei He, Naoki Goshima, et al. Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway. Journal of Cell Biology. 2016. 212. 4. 409-423

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MISC (2)：

Lectures and oral presentations (16)：

微小管結合タンパク質アルファシヌクレインの神経軸索内輸送における機能解析
(Dementia Japan 2018)
微小管結合タンパク質アルファシヌクレインの微小管および微小管依存細胞内輸送における機能解析(Alpha-synuclein binds unconventional microtubules that have a unique function)
(生物物理 2017)
電子顕微鏡トモグラフィーによって明らかになった細胞質ダイニンのモータードメインの配置(Orientation of two motor domains of cytoplasmic dynein characterized using electron computed tomography)
(生物物理 2016)
アルファシヌクレインタンパク質による輸送性微小管の制御機構(Alpha-synuclein binds unconventional microtubules that have a unique function)
(生物物理 2016)
α-synucleinは固有機能を有する非定型微小管と結合する(Alpha-synuclein binds unconventional microtubules that have a unique function)
(Dementia Japan 2016)

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Education (3)：

1989 - 1993 Osaka University Graduate School, Division of Medical Sciences Medicine
1981 - 1987 Osaka City University Faculty of Medicine
- 1986 Osaka City University Faculty of Medicine Medicine

Professional career (1)：

Work history (7)：

2003/04/01 - 現在 Osaka City University Graduate School of Medicine Basic Medicine Course Professor
2001/08/01 - 2002/03/31 埼玉医科大学、ゲノム医学研究センター神経疾患研究室助教授
1998/04/01 - 2001/07/31 動物遺伝研究所主任研究員
2001 - - Associate Professor Saitama Medical School
1995/04/01 - 1998/03/31 米国国立衛生研究所、ヒトゲノム研究センター遺伝疾患研究室ポストドクトラルフェロー

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