Yano Masafumi

2018 - 2021 Targetting ryanodine receptors for anti-heart failure and anti-arrhythmic therapy

2017 - 2020 Comprehensive treatment of heart failure, cardiac hypertrophy, and arrhythmia by controlling ryanodine receptor bound calmodulin

2016 - 2018 An attempt to regress cardiac hypertrophy by cardiomyocyte intracellular calmodulin control

2015 - 2018 Ryanodine receptor-targeting therapy for heart failure and lethal arrhythmia

2014 - 2017 Comprehensive strategy of heart failure, cardiac hypertrophy and lethal arrhythmia via stabilizing the stricture of ryanodine receptor

2014 - 2016 New molecular targeting therapy for regression of cardiac hypertrophy by inhibiting abnormal Ca2+ leak through RyR2 in hypertrophic cardiomyopathy

2011 - 2014 Development of comprehensive treatment of heart failure, hypertrophy, and arrhythmia by regulating intracellular Ca

2011 - 2013 Innovation of treatment for malignant hyperthermia and arrhythmia by inhibition of abnormal intracellular Ca2+ release through the ryanodine receptor

2010 - 2011 Development of therapeutic therapy for regression of cardiac hypertrophy in hypertrophic cardiomyopathy

2009 - 2011 Development of novel therapeutic strategy for heart failure which targets aberrant phosphorylation status in the sarcoplasmic reticulum of failing hearts

2009 - 2011 Establishment of Molecular Therapy for Severe Heart Failure and Intractable Fetal Arrhythmia

2008 - 2010 Innovation of treatment for malignant hyperthermia and arrhythmia by inhibition of abnormal intracellular Ca2+ release through the ryanodine receptor

2008 - 2010 Development of new therapy for heart failure and arrhythmia by correction of signal transduction within cardiac ryanodine receptor

2007 - 2008 Exploration into the Development of New Therapy for Heart Failure by Modifying Sarcoplasmic Reticulum Nanodomain Function

2006 - 2007 拡張不全の新しいメカニズム:細胞内カルシウム過負荷とタイチンの重要性

2006 - 2007 Ryanodine receptor as a novel therapeutic target of lethal arrhythmia

2006 - 2007 Establishment of molecular targeting therapy for duonic heart failure bystabilizmgryanodine receptor

2005 - 2006 Exploration of abnormal dephosphorylation mechanism via Protein phosphatase 1β in heart failure

2004 - 2006 Development of molecular therapy correcting abnormal intracellular Ca^<2+> regulation in chronic heart failure

2004 - 2005 Acquisition of resistance against heart failure by incorporation of ryanodine receptor stabilizing peptide to cardiomyocyte

2003 - 2004 Normalization of increased protein phosphatase 1 activity by using an high efficiency myocardial gene transfer technique in chronic heart failure

2003 - 2004 Analysis of Molecular Mechanisms Underlying the Initiation and Perpetuation of Tachyarrhythmias

2002 - 2003 Development of gene therapy for treatment of dilated cardiomyopathy and associated heart failure

2001 - 2002 不全心筋細胞内Ca過負荷に対するβ遮断薬の効果に関する研究

2001 - 2002 Research in the inhibitory effect of sarcoplasmic reticulum Ca release channel stabilizer on the development of heart failure

2000 - 2001 Molecular Analysis of Atrila fibrillation - approach through Ca2+ regulatory proteins -

1999 - 2000 Assessment of cardiac excitation-contraction coupling and effect of positive inctropic agent on Ca^<2+> regulating function of sarcoplasmic reticulum in heart failan

1997 - 1998 Assessment of Ca2+ regulating function of cardiac sarcoplasmic reticulum in the development of heart failure