Rchr
J-GLOBAL ID：200901060085355814
Update date: Nov. 05, 2024
Manabe Ichiro
マナベ イチロウ | Manabe Ichiro
Affiliation and department：
Job title：
Professor
Homepage URL (2)：
http://plaza.umin.ac.jp/manabe
,
http://plaza.umin.ac.jp/manabe/en
Research field (5)：
Cardiology
, Immunology
, Molecular biology
, Cell biology
, Metabolism and endocrinology
Research keywords (13)：
chronic inflammation
, metabolic syndrome
, smooth muscle
, differentiation
, transcription
, macrophage
, epigenetics
, 慢性炎症
, 細胞分化
, メタボリックシンドローム
, 動脈硬化
, 平滑筋
, 転写
Research theme for competitive and other funds (43)：
- 2021 - 2024 多角的アプローチによる拡張不全の病態解明と新規治療法の探索
- 2020 - 2023 Elucidation of the pathogenesis of cardiovascular diseases by stress memory through interorgan cooperation
- 2020 - 2022 Immunometabolic regulation of macropahges in chronic inflammation
- 2020 - 2022 Inflammation cellular socioloy in cardiac homeostasis and remodeling
- 2019 - 2022 Mechano-aging in heart failure
- 2018 - 2021 Exploratory research on novel cardioprotective agents
- 2018 - 2020 Inflammatory cell society in cardiac homeostasis and failure
- 2017 - 2020 Diversity of macrophages in noncommunicable disease
- 2017 - 2020 Elucidation of the pathogenesis of cardiovascular diseases by stress memory through interorgan cooperation
- 2017 - 2019 Elucidation of aging-associated modulation of adipocyte differentiation program
- 2016 - 2019 Elucidation of organ crosstalk in cardiovascular disease
- 2015 - 2018 The analysis of Nsd1 cause phenotypic change of vascular smooth muscle cells
- 2016 - 2017 Alterations in cardiac macrophages in heart failure
- 2015 - 2017 細胞老化による脂肪細胞新生ニッチの変容と脂肪組織炎症慢性化機序の解明
- 2014 - 2016 Identification and mechanical analysis of the functional lncRNA in pro-inflammatory macrophages
- 2014 - 2015 Crosstalk in circadian clock and inflammatory program
- 2010 - 2015 KLF network in chronic diseases and cancer
- 2013 - 2014 Identification of noncoding RNAs that regulate macrophage dynamics in chronic inflammation
- 2012 - 2014 内因性リガンドとしての遊離脂肪酸による生活習慣病発症機序の解明
- 2011 - 2014 Organ crosstalk and chronic inflammation in the pathogenesis of cardiovascular diseases
- 2012 - 2012 Macrophage trafficking in adipose tissue inflammation
- 2010 - 2012 Transcriptional Regulation by Mrf-2/ARID5B in Cardiovascular and Metabolic diseases
- 2011 - 2011 Elucidation of molecular mechanisms of lymphedema
- 2010 - 2011 自然炎症による心血管・腎・代謝系の恒常性維持と病態形成の分子機構
- 2010 - 2010 KLF5ネットワークによる心血管・腎・代謝疾患の病態分子機構の解明と治療展開
- 2009 - 2010 血管脂肪毒性による心血管病発症機構の解明と治療展開
- 2008 - 2010 ER stress and posttranslational modification pathways in cardiometabolic syndrome
- 2009 - 2009 心血管代謝疾患における単球・マクロファージの新機能の解明と治療法への応用
- 2007 - 2009 Molecular mechanisms that control stress response and tissue remodeling by cardiometabolic and immune systems
- 2008 - 2008 高機能ナノ粒子を用いた不安定プラークの診断=治療法の開発
- 2007 - 2007 病態診断機能を持つ高機能化ナノ粒子による心血管疾患診断・治療法の開発
- 2007 - 2007 上皮間葉移行(EMT)による心血管リモデリングの分子機構解明
- 2006 - 2007 高機能ナノ粒子によるsiRNA治療法・分子イメージング法の開発
- 2006 - 2007 Transcription factor networks in blood vessel-metabolic system crosstalk and metabolic syndrome
- 2006 - 2007 脂肪細胞分化の転写因子ネットワークによる病態形成分子機構
- 2006 - 2006 血管新生制御による肥満・メタボリックシンドローム治療法の開発
- 2002 - 2006 Molecular mechanism of organ remodeling : Gene transcription and cell-cell interaction in mesenchymal
- 2004 - 2005 新規転写因子KLF5による骨代謝調節機構の解明
- 2004 - 2005 siRNAによる心血管疾患・慢性炎症性疾患治療法開発
- 2004 - 2005 Transcriptional regulation and signaling in the interaction between vascular cells and adipocytes in metabolic syndrome
- 2004 - 2005 Zinc finger型転写因子ネットワークによる脂肪細胞機能と形質変換制御機構
- 2002 - 2003 心血管特異的薬剤誘導型遺伝子改変マウスの開発
- 心血管代謝疾患の分子機構 新規診断治療法へのトランスレーショナルリサーチ
Show all
Papers (185)：
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Kohei Otomo, Takaki Omura, Yuki Nozawa, Steven J Edwards, Yukihiko Sato, Yuri Saito, Shigehiro Yagishita, Hitoshi Uchida, Yuki Watakabe, Kiyotada Naitou, et al. descSPIM: an affordable and easy-to-build light-sheet microscope optimized for tissue clearing techniques. Nature communications. 2024. 15. 1. 4941-4941
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Yukiteru Nakayama, Katsuhito Fujiu, Tsukasa Oshima, Jun Matsuda, Junichi Sugita, Takumi James Matsubara, Yuxiang Liu, Kohsaku Goto, Kunihiro Kani, Ryoko Uchida, et al. Heart failure promotes multimorbidity through innate immune memory. Science immunology. 2024. 9. 95. eade3814
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Yumiko Oishi, Hiroyuki Koike, Naoki Kumagami, Yoshimi Nakagawa, Masaya Araki, Yoshitaka Taketomi, Yoshimi Miki, Shigeru Matsuda, Takashi Matsuzaka, Hitoshi Ozawa, et al. Macrophage SREBP1 regulates skeletal muscle regeneration. Frontiers in Immunology. 2024. 14
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Yumiko Oishi, Hiroyuki Koike, Naoki Kumagami, Yoshimi Nakagawa, Masaya Araki, Yoshitaka Taketomi, Yoshimi Miki, Shigeru Matsuda, Hyeree Kim, Takashi Matsuzaka, et al. Corrigendum: Macrophage SREBP1 regulates skeletal muscle regeneration(Front. Immunol., (2024), 14, (1251784), 10.3389/fimmu.2023.1251784). Frontiers in Immunology. 2024. 15
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Yosuke Sugita, Yoshimitsu Kuwabara, Akira Katayama, Shigeru Matsuda, Ichiro Manabe, Shunji Suzuki, Yumiko Oishi. Characteristic impairment of progesterone response in cultured cervical fibroblasts obtained from patients with refractory cervical insufficiency. Scientific Reports. 2023. 13. 1
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MISC (240)：
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真鍋 一郎. 【自律神経と免疫-ここまでわかった神経-免疫相互作用のメカニズム】心臓恒常性と心疾患における自律神経 免疫連携. 医学のあゆみ. 2021. 277. 13. 1109-1113
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真鍋 一郎. 循環・神経・免疫系の連携による恒常性の維持と破綻. 日本血栓止血学会誌. 2021. 32. 2. 167-167
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真鍋 一郎. 慢性炎症・臓器連関と生活習慣病. 日本内分泌学会雑誌. 2021. 97. 1. 201-201
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真鍋 一郎. 【女性の生活習慣病-新たな展開-】慢性炎症と生活習慣病. HORMONE FRONTIER IN GYNECOLOGY. 2021. 28. 1. 19-23
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真鍋 一郎. 【心不全と臓器連関】基礎 臓器連関を司るマクロファージ. Cardiac Practice. 2021. 31. 2. 99-102
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Patents (10)：
Books (1)：
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循環器内科ポケットバイブル
中山書店 2015 ISBN:4521742661
Professional career (1)：
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