Shoji Osami

シヨウジオサミ | Shoji Osami

Affiliation and department：
Job title： Professor

Research field (1)： Functional biochemistry

Research keywords (1)：生体関連化学生物無機化学蛋白工学酵素科学

Research theme for competitive and other funds (13)：

2022 - 2029 Dynamic Element-Effect Design for Unconventional Molecular Functions
2022 - 2027 予知生合成科学・研究総括班
2022 - 2027 Design of transition state of the enzyme catalyzing oxidation reactions by molecules that make the enzyme malfunction
2021 - 2024 Construction of enzymatic reaction system for extremely difficult hydroxylations utilizing malfunction of metalloenzyme
2015 - 2021 生体触媒の誤作動状態を利用するメタンの直接的メタノール変換

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Papers (85)：

Yuya Yokoyama, Shinya Ariyasu, Masayuki Karasawa, Chie Kasai, Yuichiro Aiba, Hiroshi Sugimoto, Osami Shoji. Bacterial acyl homoserine lactones triggered non-native substrate hydroxylation catalysed by directed-evolution-derived cytochrome P450BM3 mutants. ChemCatChem. 2024
Yuri Lee, Bohee Kim, Seonghan Kim, Elvis Wang Hei Ng, Shinya Ariyasu, Osami Shoji, Sungho Yoon, Hajime Hirao, Jaeheung Cho. Influence of Solvents on Catalytic C-H Bond Oxidation by a Copper(II)-Alkylperoxo Complex. ACS Catalysis. 2024. 14. 5. 3524-3532
Hiroaki Inaba, Yuma Shisaka, Shinya Ariyasu, Erika Sakakibara, Garyo Ueda, Yuichiro Aiba, Nobutaka Shimizu, Hiroshi Sugimoto, Osami Shoji. Heme-substituted protein assembly bridged by synthetic porphyrin: achieving controlled configuration while maintaining rotational freedom. RSC Advances. 2024. 14. 13. 8829-8836
Joshua Kyle Stanfield, Hiroki Onoda, Shinya Ariyasu, Chie Kasai, Eleanor Mary Burfoot, Hiroshi Sugimoto, Osami Shoji. Investigating the applicability of the CYP102A1-decoy-molecule system to other members of the CYP102A subfamily. Journal of Inorganic Biochemistry. 2023. 245. 112235-112235
Shinya Ariyasu, Kai Yonemura, Chie Kasai, Yuichiro Aiba, Hiroki Onoda, Yuma Shisaka, Hiroshi Sugimoto, Takehiko Tosha, Minoru Kubo, Takashi Kamachi, et al. Catalytic Oxidation of Methane by Wild-Type Cytochrome P450BM3 with Chemically Evolved Decoy Molecules. ACS Catalysis. 2023. 8613-8623

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MISC (61)：

Hitoki Nanaura, Honoka Kawamukai, Ayano Fujiwara, Takeru Uehara, Mari Nakanishi, Tomo Shiota, Masaki Hibino, Yuichiro Aiba, Pattama Wiriyasermkul, Sotaro Kikuchi, et al. Toxic PR poly-dipeptides encoded by the C9orf72 repeat expansion target Kapβ2 and dysregulate phase separation of low-complexity domains. 2019
Masayuki Karasawa, Joshua Kyle Stanfield, Sota Yanagisawa, Osami Shoji, Yoshihito Watanabe. Whole-Cell Biotransformation of Benzene to Phenol Catalysed by Intracellular Cytochrome P450BM3 Activated by External Additives. Angewandte Chemie International Edition. 2018. 57. 38. 12264-12269
M. Karasawa, J. K. Stanfield, S. Yanagisawa, O. Shoji, Y. Watanabe. Whole-Cell Biotransformation of Benzene to Phenol Catalysed by Intracellular Cytochrome P450BM3 Activated by External Additives. Angew. Chem. Int. Ed. 2018. 57. 12264-12269
M. Hibino, Y. Aiba, Y. Watanabe, O. Shoji. Peptide Nucleic Acid Conjugated with Ru-complex Stabilizing Double-Duplex Invasion Complex Even under Physiological Conditions. ChemBioChem. 2018. 19. 1601-1604
Masaki Hibino, Yuichiro Aiba, Yoshihito Watanabe, Osami Shoji. Cover Feature: Peptide Nucleic Acid Conjugated with Ruthenium-Complex Stabilizing Double-Duplex Invasion Complex Even under Physiological Conditions (ChemBioChem 15/2018). ChemBioChem. 2018. 19. 15. 1601-1604

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Patents (6)：

高圧化学反応装置
シトクロムP450モノオキシゲナーゼデコイ基質
炭化水素系基質の水酸化のための材料およびその利用
細菌の増殖抑制
ヘム蛋白質のヘム置換法

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Books (14)：

感染症「鉄の取り込みを阻害する新しい抗菌薬の開発」
アステラス製薬株式会社 2018
化学と生物「擬似基質による酵素活性化と高難度酸化反応」
公益社団法人日本農芸化学会 2018
石油学会ペトロテック「酸化酵素の誤作動を利用するバイオ触媒開発」
公益社団法人石油学会 2018
金属酵素による酸化反応と反応機構
(株)化学同人『活性酸素・フリーラジカルの科学』日本化学会編 2016
緑膿菌の増殖を阻害する「人工金属タンパク質」
公益社団法人日本化学会「化学と工業」 2015

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Lectures and oral presentations (107)：

シトクロムP450を誤作動させる分子を用いる高難度酸化反応
(日本農芸化学会大会2021 2021)
金属酵素の誤作動誘起と高難度酸化反応
(第53回酸化反応討論会 2020)
緑膿菌の鉄獲得系を利用する選択的な光増感剤輸送と光殺菌
(第94回日本感染症学会総会・学術講演会 2020)
酵素を誤作動させる分子を使う物質変換
(第六回ケムステバーチャルシンポジウム「高機能性金属錯体が拓く触媒科学」 2020)
Hydroxylation of Nonnative Substrates Catalyzed by Cytochrome P450BM3 Exploiting Decoy Molecules
(2019 Korea-Taiwan-Japan Bioinorganic Chemistry Symposium 2019)

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Professional career (2)：

工学博士 (千葉大学)
Doctor of engineering (Chiba University)

Work history (11)：

2019/04/01 - 現在 Nagoya University Graduate School of Science Division of Material Science Inorganic and Analytical Chemistry Professor
2013/04/01 - 現在 Associate professor at Graduate School of Science, Nagoya University
2013/04/01 - 2019/03/31 Nagoya University Graduate School of Science Division of Material Science Inorganic and Analytical Chemistry Associate professor
2008/10/01 - 2013/03/31 Assistant Professor at Graduate School of Science, Nagoya University
2008/10/01 - 2013/03/31 Nagoya University Graduate School of Science Division of Material Science Assistant Professor

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Awards (5)：

2013/03/22 - 日本化学会日本化学会第93回春季年会第27回若い世代の特別講演会賞
2011/09 - 生体機能関連化学部会第5回バイオ関連化学シンポジウム講演賞
2009/07/25 - 16th International Conference on Cytochrome P450 Poster award from 16th International Conference on Cytochrome P450
2007/05 - The Chemical Society of Japan EXCELLENT LECTURE AWARD from the Chemical Society of Japan
2000/12 - Center for Electronics and Photonics Chiba University-Venture Business Laboratory NANOHANA VENTURE AWARD

Association Membership(s) (5)：

American Chemical Society , The Society of Polymer Science, Japan , Japan Society of Coordination Chemistry , Division of biofunctional chemistry, The Chemical Society of Japan , The Chemical Society of Japan

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