KUDO Takashi

クドウタカシ | KUDO Takashi

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： http://www.md.tsukuba.ac.jp/basic-med/anatomy/embryology/index.html

Research field (1)： Medical biochemistry

Research theme for competitive and other funds (12)：

2021 - 2024 Integrated understanding of protein function regulated by mucin-type O-glycans
2017 - 2018 軌道上1G群と地上対照群(1G)の比較検証
2012 - 2015 N-glycosylated glycoproteome analysis of glycosyltransferase-modified mice for comprehensive understanding of glycan functions
2012 - 2015 Loss of hematopoietic mucin-type O-glycan causes thrombocytopenia in mice
2010 - 2012 O-結合型糖鎖コア1合成酵素欠損マウスの表現型解析と機能的糖タンパク質の同定

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Papers (117)：

Arai, Junya, Hayakawa, Yoku, Tateno, Hiroaki, Murakami, Keita, Hayashi, Takeru, Hata, Masahiro, Matsushita, Yuki, Kinoshita, Hiroto, Abe, Sohei, Kurokawa, Ken, et al. Impaired Glycosylation of Gastric Mucins Drives Gastric Tumorigenesis and Serves as a Novel Therapeutic Target. Gastroenterology. 2024. 167. 3. 505-521.e19
Takuto, Hayashi, Shunya, Sadaki, Ryosuke, Tsuji, Risa, Okada, Sayaka, Fuseya, Maho, Kanai, Ayano, Nakamura, Yui, Okamura, Masafumi, Muratani, Gu, Wenchao, et al. Dual-specificity phosphatases 13 and 27 as key switches in muscle stem cell transition from proliferation to differentiation. Stem Cells. 2024. sxae045
Husna, Nailil, Aiba, Tatsuya, Fujita, Shin-Ichiro, Saito, Yoshika, Shiba, Dai, Kudo, Takashi, Takahashi, Satoru, Furukawa, Satoshi, Muratani, Masafumi. Release of CD36-associated cell-free mitochondrial DNA and RNA as a hallmark of space environment response. Nature communications. 2024. 15. 1. 4814
Yoshikawa, Masaaki, Matsukawa, Mutsumi, Oshima, Hideki, Ishikawa, Chihiro, Li, Haiyan, Kudo, Takashi, Shiba, Dai, Shirakawa, Masaki, Muratani, Masafumi, Takahashi, Satoru, et al. Comparing the effects of microgravity and amyotrophic lateral sclerosis on mouse dorsal root ganglia. FRONTIERS IN SPACE TECHNOLOGIES. 2023. 4. 1162268
Sayaka Fuseya, Hiroyuki Izumi, Ayane Hamano, Yuka Murakami, Riku Suzuki, Rikako Koiwai, Takuto Hayashi, Atsushi Kuno, Satoru Takahashi, Takashi Kudo. Reduction in disialyl-T antigen levels in mice deficient for both St6galnac3 and St6galnac4 results in blood filling of lymph nodes. Scientific reports. 2023. 13. 1. 10582-10582

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MISC (71)：

工藤崇, 岡田理沙, 篠原正浩, 浅原弘嗣, 芝大, 白川正輝, 高橋智. 【「宇宙における動物実験」(I)】マウスを用いた宇宙環境応答の網羅的解析. LABIO 21. 2018. 72. 13-16
篠原正浩, 工藤崇, 新保未来, 芝大, 白川正輝, 高橋智, 浅原弘嗣. 長期宇宙滞在マウスの骨組織解析. 日本骨代謝学会学術集会プログラム抄録集. 2017. 35回. 157-157
Loss of mucin-type O-glycan causes thrombocytopenia in mice. 2014. 249. 8. 688-692
Biological significance of mucin-type O-glycosylation in megakaryocyte differentiation. 2014. 68. 5. 698-703
栂谷内晶, 小園裕子, 池原譲, 伊藤浩美, 鈴木奈美, 角田由紀, 阿部純恵, 佐藤隆, 中村京子, 鈴木實, et al. 糖脂質ポリラクトサミン合成酵素B3gnt5遺伝子欠損マウスにおける免疫機能異常. 日本糖質学会年会要旨集. 2011. 30th

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Books (13)：

医学のあゆみ
2021
The CELL
ニューサイエンス社 2018
LABIO21
日本実験動物協会 2018
実験医学別冊マウス表現型解析スタンダード
羊土社 2016 ISBN:9784758101981
モデル動物利用マニュアル・生物機能モデルと新しいリソース・リサーチツール「Fut9ノックアウトマウス」
株式会社エル・アイ・シー 2011

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Lectures and oral presentations (46)：

St6galnac3, St6galnac4のダブルノックアウトによるdisialyl-T構造の減少は、リンパ節で出血を示す
(第46回日本分子生物学会年会)
膵β細胞特異的Core 1構造由来O-型糖鎖欠損マウスを用いたインスリン分泌機構の解明
(第46回日本分子生物学会年会)
サルコペニア克服に向けた骨格筋線維タイプ制御機構の解明
(第10回日本サルコペニア・フレイル学会大会)
速筋線維の形成に不可欠な新規制御因子である大Maf転写因子の機能解析
(日本分子生物学会年会 2022)
Molecular characterization of space environment responses in internal tissues by cell-free DNA and RNA analysis of plasma samples collected from six astronauts.
(American Society for Gravity and Space Research (ASGSR) Annual Conference 2022)

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Education (1)：

- 1996 Keio University Graduate School, Division of Medical Science

Work history (4)：

2004/04 - 現在国立大学法人・筑波大学人間総合科学研究科助教授
2003/11 - 2004/03 University of Tsukuba Institute of Basic Medical Sciences
2001/04 - 2003/11 新エネルギー・産業技術総合開発機構(NEDO)フェローおよび独立行政法人・産業技術総合研究所・糖鎖工学研究センター・糖鎖遺伝子機能解析チーム共同研究員
1996/04 - 2001/03 Soka University Institute of Life Science

Association Membership(s) (5)：

LAPANESE ASSOCIATION FOR LABORATORY ANIMAL SCIENCE , The Molecular Biology Society of Japan , Japanese Association of Anatomists , THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH , THE JAPANESE BIOCHEMICAL SOCIETY

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