Wakasugi Keisuke

ワカスギケイスケ | Wakasugi Keisuke

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://park.itc.u-tokyo.ac.jp/wakasugilab/

Research field (3)： Biophysics , Molecular biochemistry , Functional biochemistry

Research keywords (8)：分子進化 , 人工蛋白質 , 多機能性蛋白質 , 蛋白質工学 , Molecular evolution , Artificial protein , Multi functional protein , Protein engineering

Research theme for competitive and other funds (17)：

2020 - 2023 アミノアシルtRNA合成酵素の新規生理機能の探索とその制御機構の解明
2017 - 2020 Elucidation of functional regulatory mechanism of human globin protein that acts as a regulator of G protein
2014 - 2017 Investigation on functional mechanisms of novel globin proteins under oxidative stress conditions by protein engineering
2011 - 2013 蛋白質間相互作用に着目したニューログロビンの酸化ストレス応答制御機構の解明
2009 - 2011 Novel function of tyrosyl-and tryptophanyl-tRNA synthetases

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Papers (51)：

Keisuke Wakasugi, Takumi Yokosawa. The high-affinity tryptophan uptake transport system in human cells. Biochemical Society transactions. 2024. 52. 3. 1149-1158
Takumi Yokosawa, Keisuke Wakasugi. Tryptophan-Starved Human Cells Overexpressing Tryptophanyl-tRNA Synthetase Enhance High-Affinity Tryptophan Uptake via Enzymatic Production of Tryptophanyl-AMP. International journal of molecular sciences. 2023. 24. 20
Akihiro Kimura, Takeshi Takagi, Thiprampai Thamamongood, Satoshi Sakamoto, Takumi Ito, Iwao Seki, Masahiro Okamoto, Hiroyuki Aono, Satoshi Serada, Tetsuji Naka, et al. Extracellular aaRSs drive autoimmune and inflammatory responses in rheumatoid arthritis via the release of cytokines and PAD4. Annals of the rheumatic diseases. 2023. 82. 9. 1153-1161
Takumi Yokosawa, Aomi Sato, Keisuke Wakasugi. Tryptophan depletion modulates tryptophanyl-trna synthetase-mediated high-affinity tryptophan uptake into human cells. Genes. 2020. 11. 12. 1-14
Keisuke Wakasugi, Takumi Yokosawa. Non-canonical functions of human cytoplasmic tyrosyl-, tryptophanyl- and other aminoacyl-tRNA synthetases. The Enzymes (Elsevier). 2020. 48. 207-242

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MISC (15)：

若杉桂輔. 「研究の世界へ:研究におけるセレンディピティ的発見の紹介」. 東京大学「初年次ゼミナール理科」テキスト『科学の技法第2版』(東京大学教養教育高度化機構Educational Transformation部門・若杉桂輔・宮島謙編)、東京大学出版会. 2024. 151-158
若杉桂輔. 「初年次ゼミナール理科の授業を受けるにあたって知っておいてほしいこと」. 東京大学「初年次ゼミナール理科」テキスト『科学の技法第2版』(東京大学教養教育高度化機構Educational Transformation部門・若杉桂輔・宮島謙編)、東京大学出版会. 2024. 2-6
若杉桂輔. ニューログロビン. ヘムタンパク質の科学:生理機能の理解とその展開に向けて(株式会社エヌ・ティー・エス). 2022. 141-148
若杉桂輔, 宮ノ腰美希. アミノアシルtRNA合成酵素の新規生理機能の探索. 生物工学会誌. 2012. 90. 557-559
若杉桂輔. ニューログロビンの生理機能の探索と新規機能性タンパク質の創製. 実験医学増刊号「活性酸素・ガス状分子による恒常性制御と疾患」、羊土社. 2012. 30. 97-102

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Patents (2)：

Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis
Tryptophanyl-tRNA synthetase derived polypeptides useful for the regulation of angiogenesis

Books (7)：

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Education (4)：

- 1996 Kyoto University
- 1996 Kyoto University Graduate School, Division of Engineering Department of Molecular Engineering
- 1991 Kyoto University Faculty of Engineering
- 1991 Kyoto University Faculty of Engineering Department of Hydrocarbon Chemistry

Professional career (1)：

Work history (12)：

2022/04 - 現在 The University of Tokyo Graduate School of Science Department of Biological Sciences
2022/04 - 現在 The University of Tokyo Graduate School of Arts and Sciences Professor
2008/06 - 2022/03 The University of Tokyo Graduate School of Science Department of Biological Sciences
2007/04 - 2022/03 The University of Tokyo Graduate School of Arts and Sciences
2007/04 - 2011/03 科学技術振興機構さきがけタイプ研究代表者兼任

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Association Membership(s) (6)：

日本植物バイオテクノロジー学会 , American Society for Biochemistry and Molecular Biology , 日本生物物理学会 , 日本蛋白質科学会 , 日本分子生物学会 , 日本生化学会

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