Rchr
J-GLOBAL ID：200901060472399978   Update date: Jul. 03, 2024

Takechi Shinji

タケチ シンジ | Takechi Shinji
Affiliation and department：
Sojo University Faculty of Pharmaceutical Sciences, Laboratory of Hygienic Chemistry

About Sojo University Faculty of Pharmaceutical Sciences, Laboratory of Hygienic Chemistry


Job title： Associate Professor
Homepage URL  (1)： http://www.ph.sojo-u.ac.jp/~stakechi/HygienChem090727/index.html
Research field  (5)： Structural biochemistry ,  Pharmaceuticals - health and biochemistry ,  Molecular biology ,  Environmental effects of chemicals ,  Environmental effects of radiation
Research keywords  (16)： 神経変性疾患 ,  エピジェネティクス ,  DNA複製 ,  ヒストン ,  クロマチン構造 ,  遺伝子発現 ,  細胞増殖 ,  転写制御 ,  アミノ酸配列 ,  ヒストン修飾酵素 ,  発現制御 ,  CATアッセイ ,  化学物質による遺伝情報複製・発現制御の攪乱機構の解明 ,  Cellar Stress ,  Radical Generation ,  Glycation
Research theme for competitive and other funds  (21)：
  • 2012 - 2015 Pathogenic mechanism of metabolic syndrome by glycation intermediates, and its sensitive diagnostic method
  • 2011 - 2013 The involvement of dihydropyrazine-induced gene damage in diabetic complication
  • 2004 - 2006 Functional substance search of horticultural products and research of the action mechanism of a functional substance
  • 2001 - 2003 Study on the regulatory mechanism for immunoglobulin expression through histone acetylation
  • 2002 - 2002 高等真核細胞のクロマチン構造動態とゲノム機能発現制御機構の解明
Show all
Papers (64)：
  • Shinji Takechi, Madoka Sawai, Yuu Miyauchi. Dihydropyrazine induces endoplasmic reticulum stress and inhibits autophagy in HepG2 human hepatoma cells. The Journal of Toxicological Sciences. 2024. 49. 7. 313-319
  • Jian-Rong Zhou, Shigenori Kinno, Kenta Kaihara, Madoka Sawai, Takumi Ishida, Shinji Takechi, Jun Fang, Toshihiro Nohara, Kazumi Yokomizo. Saponin Esculeoside A and Aglycon Esculeogenin A from Ripe Tomatoes Inhibit Dendritic Cell Function by Attenuation of Toll-like Receptor 4 Signaling. Nutrients. 2024. 16. 11. 1699-1699
  • Yuu Miyauchi, Haruna Koba, Madoka Sawai, Hisao Kansui, Shinji Takechi. Oxidative stress and cellular toxicity induced by dihydropyrazine: a comparative study with other Maillard reaction products. The Journal of Toxicological Sciences. 2023. 48. 5. 263-272
  • Madoka Sawai, Yuu Miyauchi, Takumi Ishida, Shinji Takechi. Dihydropyrazine suppresses TLR4-dependent inflammatory responses by blocking MAPK signaling in human hepatoma HepG2 cells. The Journal of Toxicological Sciences. 2022. 47. 9. 381-387
  • Yuu Miyauchi, Akane Kimura, Madoka Sawai, Keiko Fujimoto, Yuko Hirota, Yoshitaka Tanaka, Shinji Takechi, Peter I. Mackenzie, Yuji Ishii. Use of a Baculovirus-Mammalian Cell Expression-System for Expression of Drug-Metabolizing Enzymes: Optimization of Infection With a Focus on Cytochrome P450 3A4. Frontiers in Pharmacology. 2022. 13. 832931-832931
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MISC (4)：
Lectures and oral presentations  (32)：
  • 糖化産物ジヒドロピラジン類による小胞体ストレス応答
    (フォーラム2022衛生薬学・環境トキシコロジー 2022)
  • 糖化産物ジヒドロピラジンによる細胞障害の機構解明:抗酸化物質を用いた毒性軽減作用の検討
    (フォーラム2022衛生薬学・環境トキシコロジー 2022)
  • ジヒドロピラジンによる TLR4 ネガティブフィードバック機構の制御
    (フォーラム2022衛生薬学・環境トキシコロジー 2022)
  • Dihydropyrazine suppresses TLR4-dependent inflammatory responses in vivo.
    (2022)
  • 糖化産物ジヒドロピラジン類による細胞毒性の機構解明:終末糖化産物との相違点
    (日本薬学会第142年会 2022)
ｍore...
Education (2)：
  • 1987 - 1991 Osaka University
  • - 1987 Osaka University School of Science
Professional career (1)：
  • (BLANK)
Work history (3)：
  • 2011/04 - 現在 Sojo University Faculty of Pharmaceutical Sciences
  • 2005/04 - 2011/03 Sojo University Faculty of Pharmaceutical Sciences
  • 1991/04 - 2005/03 University of Miyazaki Faculty of Medicine
Association Membership(s) (2)：
日本薬学会 ,  日本分子生物学会
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