Rchr
J-GLOBAL ID:200901060588127460
Update date: Nov. 03, 2024
Kawaguchi Hiroaki
カワグチ ヒロアキ | Kawaguchi Hiroaki
Affiliation and department:
Job title:
Assistant Professor
Homepage URL (1):
https://www.kitasato-u.ac.jp/vmas/faculty/vm/vm_study06.html
Research field (3):
Veterinary medicine
, Experimental pathology
, Laboratory animal science
Research keywords (10):
Cardiovascular Pathology
, Tumor Pathology
, Animal Model
, Disease Model
, Minipig
, Microminipig
, Functional food development
, Nonclinical study
, Drug development
, Medical device development
Research theme for competitive and other funds (20):
- 2022 - 2025 天然由来機能性糖質による革新的な豚ストレス緩和法の確立
- 2021 - 2024 ブタモデルを用いたFOLFOX誘導性SOSの予防法の確立
- 2020 - 2023 カルニチン欠乏マウス雌性不妊:脂肪酸毒性と社会的ストレス脆弱性の関係性に着目して
- 2020 - 2023 体細胞クローン胚への改変処理に基づく遺伝子ノックアウトマイクロミニピッグの作出
- 2020 - 2023 Mechanism elucidation of methotrexate arteriosclerosis exacerbation with human atherosclerosis pig model
- 2018 - 2022 Overcoming Chemotherapy-Induced Liver Failure Using a Pig Model
- 2016 - 2019 Development of genetically modified microminipigs that can contribute to cancer treatments as disease model animals
- 2016 - 2019 Production of gene-modified pig of next-generation model for Alzheimer's disase
- 2016 - 2019 マイクロミニピッグ動脈硬化モデルを用いた葉酸欠乏による梗塞促進の機序解明.
- 2015 - 2017 Functional analysis of Exosome in Canine Tumor
- 2013 - 2016 Establishment of somatic cell nuclear transfer techniques in Microminipigs, the smallest pigs in the world
- 2013 - 2016 Development of a novel nutritional treatment for diabetic retinopathy based on scientific evidence.
- 2013 - 2016 Identification of novel canine tumor related microRNA for elucidating the pathology and clinical relevance
- 2013 - 2016 医療機器開発のための動脈硬化マイクロミニピッグの作出.
- 2013 - 2015 A study on cartilage regeneration using intra-articular injection of synovial fluid and synovium derived mesenchymal stem cells.
- 2011 - 2014 Osteochondral regeneration with scaffold free 3D-structure of swine adipose tissue-derived mesenchymal stem cells.
- 2010 - 2012 To elucidate effects of a low-protein diet under molecular levels, aiming at constructing the nutrition education.
- 2010 - 2011 Cruciate injury model and cruciate regeneration with MSC by using of BPR system in micro-mini pig.
- 2000 - Study on Pathogenesis of Breast Cancer
- 1999 - 乳癌の発生と進展に関する研究
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Papers (97):
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Tomonobu Yamada, Hiroaki Kawaguchi, Aki Matsuoka, Kohei Akioka, Naoki Miura, Hiroyuki Izumi, Akihide Tanimoto. Development of a Microminipig Model of Atherosclerosis for the Evaluation of a HMGCR Inhibitor. In vivo (Athens, Greece). 2024. 38. 1. 98-106
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MOE IJIRI, KOHEI AKIOKA, TAISUKE KITANO, HIROSHI MIURA, HISAYA KONO, RYOTA TERASHIMA, YOSHIKAZU FUJIMOTO, TOMOHIDE MATSUO, OSAMU YAMATO, HIROAKI KAWAGUCHI. Acupuncture Treatment Improves Transport Stress in Microminipigs Through the Acupoint in Ears. In Vivo. 2023. 37. 5. 2100-2104
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Yoshikazu Fujimoto, Moe Ijiri, Tomohide Matsuo, Hiroaki Kawaguchi. In vitro antiviral activity of persimmon-derived tannin against avian influenza viruses. Letters in applied microbiology. 2023. 76. 2
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Sumire Mitarai, Kosuke Okuya, Kazuhiro Miyane, Machiko Miyamoto, Shingo Ishikawa, Hiroaki Kawaguchi, Itaru Hatazoe, Yasuo Suda, Eriko Arima, Hiroshi Nakazato, et al. Genetic characterization of bovine respiratory syncytial viruses in Japan between 2017 and 2019. Archives of Virology. 2023. 168. 2
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Rei Toda, Satoru Seo, Yusuke Uemoto, Koshiro Morino, Hiroto Nishino, Naohiko Nakamura, Masayuki Okuno, Kohta Iguchi, Motohiko Sato, Kojiro Nakamura, et al. Clinically Relevant Model of Oxaliplatin-Induced Sinusoidal Obstruction Syndrome. Hepatology research : the official journal of the Japan Society of Hepatology. 2022. 53. 2. 145-159
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MISC (218):
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御手洗すみれ, 石川真悟, 川口博明, 畑添至, 隅田泰生, 帆保誠二, 正谷達謄, 小澤真. 2017-2018年に鹿児島県で検出された牛呼吸器合胞体ウイルスの遺伝的性状解析. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2019. 67th
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戸田怜, 瀬尾智, 上本裕介, 西野裕人, 中村直彦, 奥野将之, 佐藤元彦, 井口公太, 祝迫恵子, 田浦康二朗, et al. SOSの病態解明に向けたFOLFOX誘導性マイクロミニブタSOSモデルの確立. 日本外科学会定期学術集会(Web). 2019. 119th
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川口 博明, 谷本 昭英. NOS阻害剤投与による超短期マイクロミニピッグ動脈硬化モデルの開発. 日本毒性病理学会講演要旨集. 2019. 35回. 86-86
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佐藤正宏, 三好和睦, 松永将伍, 渡部聡, 中村伸吾, 川口博明, 谷本昭英. 体細胞核移植胚への直接 electroporation(GENTEP)は効率的なゲノム編集ブタ作製に有効である. 第41回日本分子生物学会年会要旨集(on line). 2018. 1P-0750
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御手洗すみれ, 石川真悟, 川口博明, 畑添至, 隅田泰生, 帆保誠二, 小澤真, 小澤真. 鹿児島県内で検出された牛呼吸器合胞体ウイルスの遺伝的性状の解析. 日本獣医学会学術集会講演要旨集. 2018. 161st. 363
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Lectures and oral presentations (23):
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ラットDMBA誘発乳腺腫瘤における新生仔期内分泌かく乱化学物質(DES)投与の修飾作用についての早期検索.
(第23回日本毒性病理学会 2007.1.東京 2007)
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7,12-dimethylbenz(a)anthracene誘発ラット乳がんおよび乳腺症の発生と進展について.
(第22回日本毒性病理学会 2006.1.鹿児島 2006)
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新生児期2週間DES投与ラットにおけるDMBAによる乳癌誘発への影響.
(第13回日本乳癌学会総会 2005.6.倉敷市. 2005)
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新生仔期2週間DES投与ラットにおけるDMBAによる乳癌誘発への影響.
(第21回日本毒性病理学会 2005.1.浜松. 2005)
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新生仔期男性ホルモン投与雌ラットにおけるDMBA誘発乳癌および乳腺症へのエストロジェン大量投与および卵巣摘出の影響.
(第10回良性乳腺疾患研究会 2004.1.鹿児島 2004)
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Education (2):
- 1995 - 2000 Kagoshima University
- 1989 - 1995 Kagoshima University Faculty of Agriculture
Work history (8):
- 2021/04 - 現在 Kitasato University Laboratory of Veterinary Pathology, School of Veterinary Medicine, Kitasato University Professor
- 2016/04 - 2021/03 Kagoshima University Graduate School of Medical and Dental Sciences
- 2012/04 - 2015/07 Kagoshima University Joint faculty of Veterinary Medicine, Department of Veterinary Medicine
- 2011/04 - 2012/03 Kagoshima University Veterinary Medicine, Faculty of Agriculture
- 2008/12 - 2011/03 鹿児島大学農学部獣医学科 助教
- 2007/04 - 2008/11 Kagoshima University Graduate School of Medical and Dental Sciences
- 2004/04 - 2007/03 Kagoshima University Graduate School of Medical and Dental Sciences
- 2000/04 - 2004/03 Kagoshima University Faculty of Medicine
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Committee career (7):
Awards (1):
- 2014 - JOURANL OF ATHEROSCLEROSIS AND THROMBOSIS JOURANL OF ATHEROSCLEROSIS AND THROMBOSIS AWARD 2014 Rapid Development of Atherosclerosis in the World’s Smallest Microminipig fed a high-fat/high cholesterol diet: A Useful Animal Model Because of its Size and Similarity to Human Pathophysiology.
Association Membership(s) (7):
日本獣医病理学会
, 日本実験動物医学会
, 日本毒性病理学会
, 日本獣医学会
, The Japanese Society of Toxicologic Pathology
, Japanese Socienty of Veterinary Pathology
, The Japanese Society of Veterinary Science
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