Rchr
J-GLOBAL ID：200901060926874404   Update date: Aug. 25, 2024

Totsuka Mamoru

トツカ マモル | Totsuka Mamoru
Affiliation and department：
Tokyo University of Agriculture Department of Molecular Microbiology

About Tokyo University of Agriculture Department of Molecular Microbiology


Job title： Professor
Research field  (2)： Immunology ,  Food sciences
Research keywords  (8)： Probiotics ,  Intestinal epithelial cell ,  Food Immunology ,  Functional Food ,  アレルギー ,  Gut Immunity ,  Allergy ,  Gut Associated Lymphoid Tissues
Research theme for competitive and other funds  (26)：
  • 2015 - 2018 食品因子による制御性T細胞およびB細胞誘導の分子基盤と免疫・炎症反応制御効果の解析
  • 2012 - 2015 プロバイオティクスの免疫調節機能とその食品成分による増強効果の解析
  • 2011 - 2014 Molecular analysis of skin cell activation by orally administered functional food substances
  • 2012 - 2014 制御性B細胞の分化誘導・活性化を促進する食品成分の探索
  • 2009 - 2012 食物質による腸上皮の免疫制御機能の修飾に関する分子機構の解析
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Papers (76)：
  • Michio Endo, Tadashi Yoshida, Keisatoi Ishii, Taku Iwamoto, Mamoru Totsuka, Makoto Hattori. Site-specific glycosylation and single amino acid substitution dramatically reduced the immunogenicity of β-lactoglobulin. Bioscience, Biotechnology, and Biochemistry. 2022
  • Tadashi Yoshida, Chisato Kume, Asako Sachi, Fumiko Yuyama, Naoko Tomiyama, Rina Kodama, Kiyoshi Yamada, Mamoru Totsuka, Makoto Hattori. Reduced immunogenicity of β-lactoglobulin by single amino acid substitution. Cytotechnology. 2022. 74. 6. 623-634
  • Shin Murai, Yoshifumi Yamaguchi, Yoshitaka Shirasaki, Mai Yamagishi, Ryodai Shindo, Joanne M. Hildebrand, Ryosuke Miura, Osamu Nakabayashi, Mamoru Totsuka, Taichiro Tomida, et al. A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs. Nature Communications. 2018. 9. 1. 4457
  • Qiong Ding, Kitora Tanigawa, Jun Kaneko, Mamoru Totsuka, Yoshinori Katakura, Etsuko Imabayashi, Hiroshi Matsuda, Tatsuhiro Hisatsune. Anserine/carnosine supplementation preserves blood flow in the prefrontal brain of elderly people carrying APOE e4. Aging and Disease. 2018. 9. 3. 334-345
  • Yoshinori Katakura, Mamoru Totsuka, Etsuko Imabayashi, Hiroshi Matsuda, Tatsuhiro Hisatsune. Anserine/Carnosine Supplementation Suppresses the Expression of the Inflammatory Chemokine CCL24 in Peripheral Blood Mononuclear Cells from Elderly People. NUTRIENTS. 2017. 9. 11
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MISC (65)：
  • 戸塚護. 免疫力を高める栄養と食事について. めいいく((株)明治の食育情報誌). 2021. 10. 2-3
  • 戸塚護. 免疫を調節する食品の役割. メディアミルクセミナーニュースレター(https://www.j-milk.jp/report/media/h4ogb40000005tju.html). 2021. 51. 1-4
  • 戸塚護. 免疫機能を整えるための 食生活と牛乳などの役割. (一社)Jミルク ウェブサイト(https://www.j-milk.jp/knowledge/growth/h4ogb40000004vsn.html). 2020
  • Mamoru Totsuka. Toward Effective Modulation of Immune and Intestinal Functions by Food. Journal of Intestinal Microbiology. 2020. 34. 19-22
  • TOTSUKA Mamoru, AOKI-YOSHIDA Ayako. Effect of oral administration of Lactobacillus gasseri OLL2809 on the induction of oral tolerance. Clinical Immunology and Allergology. 2019. 71. 2. 138-145
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Patents (10)：
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Books (27)：
  • 食品免疫学事典
    朝倉書店 2021 ISBN:9784254431261
  • The Best Diet for Healthy Immune System to Prevent Viral Infections
    2021 ISBN:9784594087081
  • 牛乳・乳製品と免疫調節
    牛乳と健康ーわが国における研究の軌跡と将来展望、ライフサイエンス出版 2015
  • 21世紀のバイオサイエンス「実験農芸化学」
    2013
  • 食品と免疫・アレルギー事典
    朝倉書店 2011
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Lectures and oral presentations  (79)：
  • 食品による免疫・炎症反応の制御と健康維持
    (おかやまバイオアクティブ研究会第61回シンポジウム「アンチエイジングを志向した機能性食品開発の最先端研究」 2022)
  • 食品成分による「免疫力」増強とアレルギー制御、 その基礎と最新動向
    (テックデザイン技術講習会 2021)
  • Modulation of Immune / inflammatory reaction by food
    (2020)
  • Dietary habits to regulate immune function and role of milk
  • Gut microflora and Health
    (2020)
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Works (4)：
  • Study on immunological responses to microorganisms of intestinal epithelial cells.
    2002 -
  • Study on the effect of dietary nucleotides on immune responses.
    1998 - 2000
  • Manipulation of allergic reaction by altering primary structure of an allergen
    1999 -
  • Study on primary response of naive T cells to altered peptide ligands.
    1997 -
Education (2)：
  • 1988 - 1990 The University of Tokyo Graduate School of Agriculture Department of Agricultural Chemistry
  • 1984 - 1988 The University of Tokyo Faculty of Agriculture Department of Agricultural Chemistry
Professional career (2)：
  • Master of Agriculture (The University of Tokyo)
  • Ph. D. (The University of Tokyo)
Work history (6)：
  • 2022/04 - 現在 Tokyo University of Agriculture Department of Molecular Microbiology Professor
  • 2017/10 - 2022/03 Nippon Veterinary and Life Science University Department of Food Science and Technology, Faculty of Applied Life Science Professor
  • 2006/04 - 2017/09 The University of Tokyo Deparment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences Associate Professor
  • 2009/08 - 2011/07 Ministry of Education, Culture, Sports, Science and Technology(MEXT) Senior Scientific Research Specialist
  • 1998/06 - 2006/03 The University of Tokyo Deparment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences Project Associate Professor
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Committee career (15)：
  • 2021/06 - 現在 The Intestinal Microbiology Society Director
  • 2019/11 - 現在 BMFH出版会 Associated Editor(Bioscience of Microbiota, Food and Health誌)
  • 2018/05 - 現在 (一社)日本乳業協会 理事
  • 2016 - 現在 (公社)日本農芸化学会 代議員
  • 2012/04 - 現在 牛乳乳製品健康科学会議 免疫調節分科会委員
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Awards (3)：
  • 2021/03 - Japan Society for Bioscience, Biotechnology, and Agrochemistry 2020 BBB Most-Cited Review Award
  • 2015 - Japanese Association for Food Immunology Japanese Association for Food Immunology Award
  • 2010 - The Japan Society for Bioscience, Biotechnology, and Agrochemistry The Excellent Paper Award Published in Bioscience, Biotechnology, & Biochemistry
Association Membership(s) (6)：
JAPAN SOCIETY OF NUTRITION AND FOOD SCIENCE ,  The Intestinal Microbiology Society ,  Japanese Association for Food Immunology ,  Japanese Association for Animal Cell Technology ,  Japanese Society for Immunology ,  The Japan Society for Bioscience, Biotechnology, and Agrochemistr
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