Ikegame Mika

2019 - 2022 Regulation of bone regeneration by exosomes and sugar chains derived from mechanical stress highly reactive mesenchymal stem cells

2017 - 2020 Control of cell differentiation and proliferation by ultrasound: elucidation of the role of epigenome

2016 - 2020 Elucidation of novel interactions between melatonin and bone metabolism regulating hormones / cytokines

2015 - 2020 Spatio-temporal and molecular cytological analysis of the osteocyte signaling mechanism controlling alveolar bone remodeling

2016 - 2019 Role of Sox9 and its ubiquitin ligase on the Circadian growth rhythm in chondrocytes

2016 - 2019 Functional analysis of an osteoclast-specific G protein-coupled receptor, GPR137B, and exploration of its regulatory molecules

2015 - 2018 Control mechanism on structure, composition, and calcification of dentin and odontoblasts by time information transmitter melatonin

2015 - 2018 Analysis of bone metabolism under hyperglycemia using unique type 2 diabetes model and proposal of improvement method for bone metabolism in type 2 diabetes by exercise.

2014 - 2017 Control of cell differentiation by ultrasound through epigenetic mechanisms

2013 - 2017 Interactive effetcs of melatonin and mechanical stress on bone cells

2012 - 2016 Alveolar bone regeneration based on the low invasive therapy using in vivo BMP gene transfer.

2012 - 2015 Analysis of bone metabolism in micro- and hypergravity using a novel hard-tissue model

2012 - 2015 Investigating the Alveolar Bone-Loss Mechanism in Elderly Women, using Ovariectomized Monkey Subjects with Ligature-Induced Periodontitis.

2012 - 2015 The mechanism of synchronization among the shell gland and medullary bone on the eggshell calcification in Japanese quail.

2011 - 2013 Molecular basis of epigenetic regulation by ultrasound

2010 - 2012 A role of Wnt/beta-catenin signal network on the stimulated bone formation under mechanical stress.

2009 - 2011 Identification of the exercise not for bone formation but for bone absorption suppression and investigation of the underlying mechanisms

2007 - 2008 Morphological studies on cytoskeleton and adherent molecules of the cells in mechanically stretched bone sutures

2004 - 2005 The role of cell cortex structures in mechanical stress signal transduction in osteoblasts.

2002 - 2003 Possible roles of adhesion complex and cytoskeleton as a mechano-receptor in osteoblasts.

2002 - 2003 Molecular mechanism of osteogenesis-induced osteogenesis

2001 - 2003 Elucidation of features of jaw bone osteoporosis and establishment of preventive methods against it

2000 - 2001 On the analysis and regulatory mechanism of genes responsible for mechanical stress-induced osteoblast differentiation and osteogenesis

1999 - 2000 伸展刺激による頭頂骨矢状縫合部における骨形成促進機構の分子生物学的・形態学的解析

1999 - 2000 Reasearch for control system of bone morphogy adapted to ageing or environment

1998 - 1999 Mechanism of mechanical stress-induced osteoblast differentiation and osteogenesis

1997 - 1998 骨組織細胞における機械的刺激の受容応答機構およびその調節因子の解明