Rchr
J-GLOBAL ID：200901061244118353
Update date: Feb. 01, 2024
Hirohata Shunsei
ヒロハタ シュンセイ | Hirohata Shunsei
Affiliation and department：
Kitasato University School of Medicine Faculty of Medicine
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Detailed information
Job title：
Associate Professor
Research field (3)：
Allergies and connective tissue disease
, Internal medicine - General
, Immunology
Research keywords (34)：
Tリンパ球
, Bリンパ球
, B細胞
, T細胞
, SLE
, 抗CD3抗体
, 固相化抗CD3抗体
, サプレッサーT細胞
, LFA-1
, 抗神経細胞抗体
, 単球
, 髄液
, グルタミン酸レセプター
, mRNA
, ループス精神病
, エピトープ
, 抗リボソームP抗体
, アポトーシス
, IL-12
, ICAM-1
, 免疫グロブリン
, CNSループス
, サイクリンA
, 神経芽細胞腫細胞
, 全身性エリテマトーデス
, 核酸結合タンパク質
, CD4+T細胞
, Th1
, Staphylococcus aureus
, 中枢神経ループス
, 免疫学
, 内科学一般(リウマチ学)
, Immunology
, Internal Medicine(Rheumatology)
Research theme for competitive and other funds (22)：
2011 - 2011 Analysis of the mechanism of production of pathologic autoantibodies
2008 - 2010 Analysis of anti-neuronal antibodies in neuropsychiatric systemic lupus erythematosu
2004 - 2005 Role of anti-neuronal antibodies in the pathogenesis of central nervous system lupus erythematosus
2002 - 2003 Molecular analysis of the abnormal expression of CD 154 in T cells as a mechanism of induction of autoinimune disease.
2000 - 2001 ベーチット病における進行性神経病変の発症機序の解析
2000 - 2001 Investigation into the roles of autoantibodies in the pathogenesis of central nervous system lupus erythematosus.
1998 - 1999 Molecular analysis of the mechanism of abnormal immune functions in Behcet's diseases
1998 - 1999 Analysis of the molecular machaism of defective T cell functions in reqularing B cell activation in various autoimmune diseases
1994 - 1995 Analysis of the mechanism of abnormal B cell activation characteristic of various autoimmune diseases
1993 - 1994 Analysis of the mechanism of abnormal T cell function in Behcet's disease
1991 - 1992 Molecular analysis of the abnormal T cell function as a pathogenesis of autoimmune diseases
1989 - 1991 The role of rheumatoid factor on altered immune responses of intra-articular lymhocytes in rheumatoid arthritis.
1989 - 1990 Investigation Into the Mechanism of Polyclonal B Cell Activation as a Pathogenesis of Autoimmune Diseases
1987 - 1988 A study on the mechanism of immunoglobulin synthesis via complement receptor in patients with autoimmune diseases.
関節リウマチの病態形成における骨髄CD34陽性細胞の異常の検討
関節リウマチの主要病態としてのBリンパ球活性化における骨髄内系細胞の役割の解析
ベーチェット病のTリンパ球機能異常の解析
自己免疫疾患における抑制性Tリンパ球機能不全のメカニズムの分子生物学的解析
Analysis of abnormality in bone marrow CD34+ cells in the pathogenesis of rheumatoid arthritis
Analysis of the role of bone-marrow derived monocytes/macrophages in the abnormal B cell activation in rheumatoid arthritis
Analysis of the abnormal T cell functions in Behcet's disease
Molecular analysis of the mechanism for abnormal suppressor T cell functions in autoimmune disease
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Papers (49)：
Shunsei Hirohata, Hirotoshi Kikuchi, Tetsuji Sawada, Hiroko Nagafuchi, Masataka Kuwana, Mitsuhiro Takeno, Yoshiaki Ishigatsubo. Clinical characteristics of neuro-Behcet's disease in Japan: a multicenter retrospective analysis. MODERN RHEUMATOLOGY. 2012. 22. 3. 405-413
Atsushi Hashimoto, Hirahito Endo, Hirobumi Kondo, Shunsei Hirohata. Clinical features of 405 Japanese patients with systemic sclerosis. MODERN RHEUMATOLOGY. 2012. 22. 2. 272-279
Fumihito Suzuki, Tetsuo Kubota, Yasunari Miyazaki, Kinya Ishikawa, Masashi Ebisawa, Shunsei Hirohata, Takashi Ogura, Hidehiro Mizusawa, Toshio Imai, Nobuyuki Miyasaka, et al. Serum level of soluble CX3CL1/fractalkine is elevated in patients with polymyositis and dermatomyositis, which is correlated with disease activity. ARTHRITIS RESEARCH & THERAPY. 2012. 14. 2. R48
Yoshiyuki Arinuma, Hirotoshi Kikuchi, Kaori Aramaki, Masahisa Kyogoku, Shunsei Hirohata. Histopathological analysis of cerebral hemorrhage in systemic lupus erythematosus complicated with antiphospholipid syndrome. MODERN RHEUMATOLOGY. 2011. 21. 5. 509-513
Shunsei Hirohata, Tatsuo Nagai, Kurumi Asako, Tetsuya Tomita, Hideki Yoshikawa. Induction of type B synoviocyte-like cells from plasmacytoid dendritic cells of the bone marrow in rheumatoid arthritis and osteoarthritis. CLINICAL IMMUNOLOGY. 2011. 140. 3. 276-283
ｍore...
MISC (89)：
Shunsei Hirohata. Is the long-term use of systemic corticosteroids beneficial in the management of Behcet's syndrome?. NATURE CLINICAL PRACTICE RHEUMATOLOGY. 2006. 2. 7. 358-359
N Yajima, T Kasama, T Isozaki, T Odai, M Matsunawa, M Negishi, H Ide, Y Kameoka, S Hirohata, M Adachi. Elevated levels of soluble fractalkine in active systemic lupus erythematosus - Potential involvement in neuropsychiatric manifestations. ARTHRITIS AND RHEUMATISM. 2005. 52. 6. 1670-1675
Tatsuo Nagai, Yoshiyuki Arinuma, Tamiko Yanagida, Kazuhiko Yamamoto, Shunsei Hirohata. Anti-Ribosomal P Protein Antibody in Human Systemic Lupus Erythematosus Up-Regulates the Expression of Proinflammatory Cytokines by Human Peripheral Blood Monocytes. ARTHRITIS AND RHEUMATISM. 2005. 52. 3. 847-855
Inhibition of CX3CL1 (Fractalkine) improves ecxperimental autoimmune myositis in SJL/J mice. J Immunol. 2005. 175: 6987-6996
Differential effects of IFN-γ on the expression of varioue Th2 cytokines in human CD4+ T cells. J Allergy Clin Immunol. 2005. 116: 205-212
ｍore...
Patents (4)：
骨髄液の再生方法
アポトーシス誘導剤
全身性エリテマトーデス病態診断剤
全身性エリテマトーデス病態診断剤
Books (1)：
Abnormal T cell responses to bacterial antigens in patients with Behcet's disease
Behcet's Disease Elsevier Science Publishers B. V. 1993
Works (2)：
関節リウマチ骨髄異常に関する研究
1998 - 2006
血清抗リボソームP抗体のSLE病態診断上の意義に関する研究
1997 - 2006
Education (2)：
- 1980 The University of Tokyo Faculty of Medicine
- 1980 The University of Tokyo Faculty of Medicine
Professional career (1)：
(BLANK) (The University of Tokyo)
Work history (11)：
2008 - 2011 Kitasato University School of Medicine
1992 - 1996 Teikyo University School of Medicine
1996 - - 帝京大学医学部内科 助教授
1989 - 1992 The University of Tokyo Faculty of Medicine University Hospital
1988 - 1989 The University of Tokyo Faculty of Medicine
1986 - 1988 米国テキサス州University of Texas Southwestern
1986 - 1986 The University of Tokyo Faculty of Medicine University Hospital
1984 - 1986 日本国有鉄道中央鉄道病院神経・血液・内分泌内科
1982 - 1984 The University of Tokyo Faculty of Medicine
1980 - 1982 東京大学医学部附属病院内科 研修医
Medical Center (Dr.Lipsky) 留学
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Committee career (6)：
2010/04 - 現在 日本内科学会 評議員
日本炎症・再生学会 評議員
日本臨床リウマチ学会 評議員
日本臨床免疫学会 評議員
日本アレルギー学会 評議員
日本リウマチ学会 評議員
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Awards (6)：
1999 - 東京都医師会医学研究賞 奨励賞
1997 - Teikyo Prize at Harvard University
1996 - 東大医師会医学賞
1996 - 日本リウマチ財団 北陸製薬・骨,関節疾患学術奨励賞
1994 - 日本臨床免疫学会会長奨励賞
1994 - 日本リウマチ学会賞
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Association Membership(s) (13)：
日本感染症学会
, 日本炎症・再生学会
, 日本輸血学会
, 日本臨床病理学会
, 日本臨床リウマチ学会
, 日本神経学会
, 日本臨床免疫学会
, 日本アレルギー学会
, アメリカ免疫学会(The American Association of Immunologists)
, 日本免疫学会
, 日本内科学会
, アメリカリウマチ学会(The American College of Rheumatology)
, 日本リウマチ学会
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