Rchr

J-GLOBAL ID：200901061809273110 Update date: Oct. 31, 2024

Hayashi Takashi

ハヤシタカシ | Hayashi Takashi

Affiliation and department：
Job title： Associate Professor

Research field (6)： Structural/physical organic chemistry , Bioorganic chemistry , Biochemistry , Synthetic organic chemistry , Inorganic and coordination chemistry , Molecular biochemistry

Research keywords (5)：錯体化学 , タンパク質工学 , 超分子化学 , 生体機能関連化学 , 生物無機化学

Research theme for competitive and other funds (56)：

2022 - 2029 Unified catalysis concepts from molecular design to sustainable chemicals and materials
2020 - 2024 Construction of a Structural and/or Functional Model of New Light-harvesting System Using Artificial Hemoprotein Assembly
2018 - 2023 High-Performance Catalyst and Device Prepared by Metalloporphyrin
2018 - 2021 Functional Model of Methane Generation Enzyme MCR Having Ni-containing F430 as a Cofactor
2015 - 2020 Precise Formation of a Catalyst Having a Specified Field for Use in Extremely Difficult Substrate Conversion Reactions

2015 - 2020 Construction of a New Catalyst Having a Protein Cavity as a Reaction Scaffold

2016 - 2019 Construction of Artificial Light Harvesting System Using Hemoprotein Assemblies

2015 - 2019 A transition state of biologically relevant Fe hydride: Reactivity studies in a protein cavity

2015 - 2018 Development of suramolecular recruiting technology for elucidation of dynamics of protein assemblies involved in cell division

2015 - 2017 タンパク質相互作用および細胞シグナル制御をターゲットとするポルフィリン分子の合成

2014 - 2017 Construction of Engineered Myoglobin toward a Catalyst for Alkane Hydroxylation

2015 - 2016 反応鍵中間体コバルト1価種を経由するメチオニン合成酵素の機構解明

2015 - 2016 ヘムタンパク質を用いた光エネルギー捕集系モデルの構築とエネルギー・物質変換

2013 - 2016 Non-Precious Metal Carbon Catalysts containing Multinuclear Active SItes

2010 - 2016 Construction of a New Catalyst Using a Protein Matrix

2010 - 2016 Development of New Catalytic Reactions Directed to Straightforward Synthesis

2012 - 2015 Functional Model of Vitamin B12 and F430-dependent Enzymes

2011 - 2012 Construction of Artificial Biocatalysts containing Non-natural Dimetallic Active Site

2010 - 2011 Construction of a Nitrogenase Model Using Metal Cluster-Containing Metallothionein

2009 - 2010 ヘムタンパク質をバイオモチーフとする巨大超分子ポリマーの形成評価と機能化

2008 - 2010 New Trial toward the Construction of Self-Assembling Supramolecular Hemoproteins

2008 - 2009 ヘムプロピオン酸側鎖が関与するヘムタンパク質の高次構造形成と機能発現機序の解明

2008 - 2009 タンパク質マトリクスを利用した新規生体金属触媒の創製と小分子の活性化

2008 - 2009 金属ポルフィリノイド-典型元素間の結合形成と反応性を支配する配位子効果

2008 - 2008 オリゴペプチド鎖を配位空間として用いた金属酵素機能モデルの構築

2007 - 2007 ニトロゲナーゼ機能モデルをめざしたメタロチオネイン多金属錯体の合成と触媒活性評価

2007 - 2007 金属ポルフィノイド-14族元素間の結合形成と反応性を支配する配位子効果の評価

2006 - 2007 ヘムタンパク質のヘムポケットを配位空間に利用した新しい機能性触媒の開拓

2005 - 2007 Preparation of Heme-Protein Based Birtatslysts with High Enzymatic Activity

2004 - 2006 Dynamic Structure and Novel Functions of Dicobalt Complexes

2003 - 2005 ヘムオキシゲナーゼと鉄ポルフィセン複合体による新しい生体分子触媒の創製

2002 - 2004 Extreme Functionalization of Hemoproteins upon the Direct Chemical Modification to Heme Framework

2001 - 2003 Development of Novel Tetrapyrrole Ligands and Their Metal Complexes with New Functions

2001 - 2003 Development of heme-based highly efficient biocatalysts

2002 - 2002 ポルフィリン国際会議を契機にした当該分野の学際領域における活性化の企画調査

2001 - 2001 人工的疎水場を有するミオグロビンの外部分子との非共有結合相互作用と動的高機能発現

2000 - 2001 Elucidation of Reaction Mechanism of Abnormal Heme Metabolism by Synthetic Methods

1999 - 2001 Chemical Approach to New Conversion of Hemoprotein Function

2000 - 2000 ヘムタンパク質の高機能変換をめざしたミオグロビン表面への精密分子認識部位の導入

1999 - 1999 ヘムタンパク質の高機能変換をめざしたミオグロビン表面への精密分子認識部位の導入

1999 - 1999 コバルト-炭素結合を鍵中間体とする分子変換反応

1999 - 1999 優れた酸化触媒活性を示す再構成ミオグロビンの構築

1998 - 1999 Studies on Weak Intermolecular Interactions by Low-Frequency Vibrational Coherence

1997 - 1999 Electroorganic Synthesis Mediated by Metalloenzyme Models

1998 - 1998 コバルト-炭素結合を鍵中間体とする分子変換反応

1998 - 1998 金属錯体と人口ペプチド脂質によりなるハイブリッド膜の触媒機能

1997 - 1998 軸性キラリティーを有するビスポルフィリン化合物の合成とその機能

1997 - 金属ポルフィリン類縁体の合成と構造・反応性評価

1997 - Synthesis, Structure and Reactivity of New Metalloporphyrins

1992 - 1995 Dynamics of molecular recognition

1995 - ヘムタンパク質の高機能変換

1995 - Modification of Hemoproteins

1991 - 1992 分子認識能を有するポルフィリン金属錯体の合成と機能に関する研究

1992 - Architecture of Supromolecular Composites and their Electron Transfer

1991 - 1991 含ニッケル酵素に着目した新規大環状ニッケル錯体の合成とそのモデル化反応

生体金属分子を基盤とした機能性分子の構築

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Papers (232)：

Ryusei Kano, Koji Oohora, Takashi Hayashi. Photo-induced imine reduction by a photoredox biocatalyst consisting of a pentapeptide and a Ru bipyridine terpyridine complex. Journal of Inorganic Biochemistry. 2024. 259
Shunsuke Kato, Miteki Abe, Harald Gröger, Takashi Hayashi. Reconstitution of Myoglobin with Iron Porphycene Generates an Artificial Aldoxime Dehydratase with Expanded Catalytic Activities. ACS Catalysis. 2024. 13081-13087
Yoshiyuki Kagawa, Koji Oohora, Takashi Hayashi. Intramolecular C-H bond amination catalyzed by myoglobin reconstituted with iron porphycene. Journal of Inorganic Biochemistry. 2024. 252
Koji Oohora, Kazuki Kageyama, Yuri Hidaka, Takashi Hayashi. Elasticity tuning of a hexameric hemoprotein-based hydrogel by mutation of its protein building block. Chemistry Letters. 2024. 53. 2
Koji Oohora, Kazuki Kageyama, Hiroki Innami, Takashi Hayashi. Mechanochemical responses in β-lactoglobulin-based hydrogels: protein unfolding and chemical modification through compression. Chemistry Letters. 2024. 53. 2

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MISC (34)：

Takashi Hayashi, Shunsuke Kato. Engineering of hemoproteins. Comprehensive Inorganic Chemistry III. 2023. 215-230
Hayashi, T., Oohora, K. CHAPTER 3: Myoglobin Derivatives Reconstituted with Modified Metal Porphyrinoids as Structural and Functional Models of the Cytochrome P450 Enzymes. RSC Metallobiology. 2019. 2019-January. 13. 63-78
Hayashi, T. Construction of a Hemoprotein Supramolecular 671 Polymer. Kobunshi. 2017. 66. 12. 671-672
Oohora, K., Hayashi, T. Reconstitution of Heme Enzymes with Artificial Metalloporphyrinoids. Methods in Enzymology. 2016. 580. 439-454
原田裕史, 小野田晃, 砂川直輝, 五十嵐圭日子, 林高史. ヘムを介して配向担持されたセロビオースデヒドロゲナーゼ修飾バイオ電極の構築. 錯体化学会討論会講演要旨集. 2015. 65th

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Patents (1)：

Preparation of 2-Deoxy-2-fluoro-glycoside-bound Nucleotides as Glycosyltransferase Inhibitors

Books (6)：

RSC Metallobiology
RSC 2019
Peroxidase and Peroxygenase Activities of a Myoglobin Reconstituted with an Iron Porphycene
Biomolecular Chemistry, A Bridge for the Future, Proceeding of the ISBC2003, 2003
Porphyrins and Metalloporphyrins as Receptor Models in Molecular Recognition
The Porphyrin Handbook 2000
Porphyrins and Metalloporphyrins as Receptor Models in Molecular Recognition
The Porphyrin Handbook (Academic Press) 2000
Hydrogen Peroxide Oxidation of the Silicon-Carbon Bond : Mechanistic Studies
Frontiers of Organosilicon Chemistry 1991

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Works (7)：

ポルフィセン金属錯体を用いた新規触媒開発
1999 - 2001
Development of New Catalyst by Metalloporphycene
1999 - 2001
修飾ヘムタンパク質の機能化
2000 -
蛋白質フラスコを用いた高効率酵素型触媒
2000 -
New Functionalization of Modified Hemoproteins
2000 -

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Education (2)：

1985 - 1990 Kyoto University Graduate School of Engineering
1981 - 1985 Kyoto University Faculty of Engineering

Professional career (1)：

Doctor of Engineering (Kyoto University)

Work history (6)：

2005/04 - 現在 Faculty of Engineering, Osaka University Department of Applied Chemistry professor
2005/04 - 2007/03 Institute for Molecular Science Visiting Professor
1997 - 2005 Kyushu University
2000 - 2003 科学技術振興事業団さきがけ21「変換と制御」研究員
1990 - 1997 京都大学助手

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Committee career (5)：

2022/04 - 現在日本学術振興会学術システム研究センタープログラムオフィサー(専門研究員)
2019/05 - 現在近畿化学協会理事
2023/03 - 2024/02 日本化学会近畿支部支部長
2019/05 - 2021/05 日本化学会理事
2018/08 - 2020/09 錯体化学会副会長・理事

Awards (12)：

2022/10 - Alexander von Humboldt Foundation Humboldt Research Award
2010 - 日本化学会第27回日本化学会学術賞
2008 - BCSJ Article Awards
2006 - 第7回酵素応用シンポジウム研究奨励賞
2001 - 2001 九州大学総長賞

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Association Membership(s) (9)：

錯体化学会 , 高分子学会 , 近畿化学協会 , 有機合成化学協会 , アメリカ化学会 (American Chemical Society) , 日本化学会 , Society of Porphyrins and Phthalocyanines (SPP) , Society of Biological Inorganic Chemistry (SBIC) , American Chemical Society (Inorg. Div. and Organic Div.)

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