Rchr
J-GLOBAL ID：200901061979847120
Update date: Feb. 01, 2024
Takahashi Yoshitaka
タカハシ ヨシタカ | Takahashi Yoshitaka
Research field (4)：
Pathobiochemistry
, Medical biochemistry
, Molecular biochemistry
, Home economics, lifestyle science
Research keywords (2)：
リポキシゲナーゼ シクロオキシゲナーゼ アラキドン酸
, lipoxygenase cyclooxygenase arachidonic acid
Research theme for competitive and other funds (16)：
- 2020 - 2023 血小板型12-リポキシゲナーゼはNASH進展における肝線維化に関与するか
- 2018 - 2022 Study on effect of changes in food ingredients on the catalytic activities of arachidonic acid-metabolizing enzymes
- 2016 - 2020 Study aiming for the development of NASH prevention focusing on lipoxygenase
- 2013 - 2016 Study on anti-leukotriene single-chain antibody aiming to develop medicines for chronic inflammatory diseases
- 2011 - 2013 Searching for neurodegenerative disease-related factors in the metabolic systems of ADMA-containing protein and the elucidation of the functional mechanism
- 2009 - 2011 Studies on the protective effect of acetate on metabolic syndrome
- 2008 - 2010 Study for the development of a novel treatment to prevent atherosclerosis with guava tea
- 2007 - 2009 Metabolism of n-3 polyunsaturated fatty acids by lipoxygenases and production of novel bioactive agents
- 2002 - 2003 Investigation of the functional molecules and mechanism on the LDL oxidation causing atherosclerosis -essential roles of 12/15-lipoxygenase-
- 2000 - 2002 Pathophysiological role of lipid molecules produced by 12/l5-lipoxygenase
- 1997 - 1998 ヒト乳癌細胞の増殖ならびに浸潤転移におけるエイコサノイドの役割
- 1996 - アラキドン酸代謝酵素の分子生物学的研究
- 1992 - 1993 Molecular biological studies on cyclooxygenases and lipoxygenases dynamics
- 1992 - 1992 脳下垂体に見出されるアラキドン酸12-リポキシゲナーゼの生理的役割の研究
- 1989 - 1991 Study on the physiological and pathological dynamics of cyclooxygenase and lipoxygenase enzymes
- Molecular biological studies on arachidonate-metabolizing enzymes
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Papers (82)：
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Izumi Tsukayama, Yuki Kawakami, Asako Tamenobu, Keisuke Toda, Saya Maruoka, Yuki Nagasaki, Yoshiko Mori, Risa Sawazumi, Kensuke Okamoto, Keita Kanzaki, et al. Malabaricone C derived from nutmeg inhibits arachidonate 5-lipoxygenase activity and ameliorates psoriasis-like skin inflammation in mice. Free Radical Biology and Medicine. 2022
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Yuki Nagasaki, Erika Kawai, Saya Maruoka, Miho Osumi, Izumi Tsukayama, Yuki Kawakami, Yoshitaka Takahashi, Yuka Okazaki, Yoshimi Miki, Yoshitaka Taketomi, et al. Lipid profiling reveals the presence of unique lipid mediators in human milk from healthy and mastitic subjects. Biochemical and Biophysical Research Communications. 2022
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Izumi Tsukayama, Takuto Mega, Nana Hojo, Keisuke Toda, Yuki Kawakami, Yoshitaka Takahashi, Toshiko Suzuki-Yamamoto. Diosgenin suppresses COX-2 and mPGES-1 via GR and improves LPS-induced liver injury in mouse. Prostaglandins & other lipid mediators. 2021. 156. 106580-106580
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Tetsuo Mitsui, Satoshi Makino, Gen Tamiya, Hiroko Sato, Yuki Kawakami, Yoshitaka Takahashi, Toru Meguro, Hiroko Izumino, Yosuke Sudo, Ikuo Norota, et al. ALOX12 mutation in a family with dominantly inherited bleeding diathesis. Journal of human genetics. 2021. 66. 8. 753-759
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Yoshiko Mori, Yuki Kawakami, Keita Kanzaki, Akemi Otsuki, Yuka Kimura, Hibiki Kanji, Ryoma Tanaka, Izumi Tsukayama, Nana Hojo, Toshiko Suzuki-Yamamoto, et al. Arachidonate 12S-lipoxygenase of platelet-type in hepatic stellate cells of methionine and choline-deficient diet-fed mice. Journal of biochemistry. 2020. 168. 5. 455-463
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MISC (67)：
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戸田圭祐, 森香子, 森香子, 川上祐生, 神崎圭太, 神崎圭太, 玉井玲名, 田中龍舞, 津嘉山泉, 山本登志子, et al. 非アルコール性脂肪性肝炎の進展に寄与する12-リポキシゲナーゼの解明. 脂質生化学研究. 2021. 63
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長崎祐樹, 川井恵梨佳, 丸岡紗也, 大角美穂, 津嘉山泉, 川上祐生, 高橋吉孝, 岡崎愉加, 三木寿美, 山本圭, et al. ヒトとウシの乳汁中脂質プロファイル比較. 脂質生化学研究. 2021. 63
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田中龍舞, 森香子, 森香子, 川上祐生, 神崎圭太, 神崎圭太, 津嘉山泉, 川上貴代, 山本登志子, 高橋吉孝. NASHモデルマウス肝で発現上昇する血小板型12S-リポキシゲナーゼ. 日本栄養・食糧学会大会講演要旨集. 2021. 75th
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長崎祐樹, 丸岡紗也, 大角美穂, 津嘉山泉, 川上祐生, 高橋吉孝, 岡崎愉加, 三木寿美, 山本圭, 村上誠, et al. ヒトとウシの乳汁中脂質メディエータープロファイル. 日本栄養・食糧学会大会講演要旨集. 2021. 75th
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津嘉山泉, 目賀拓斗, 北條奈々, 戸田圭祐, 川上祐生, 高橋吉孝, 山本登志子. 植物ステロールジオスゲニンによるグルココルチコイド受容体を介したプロスタグランジンE2合成系酵素の発現抑制とLPS誘発肝障害モデルマウスにおける効果. 日本生化学会大会(Web). 2021. 94th
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Books (1)：
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Mammalian Lipoxygenases.
P. Curtis-Prior (ed), The Eicosanoids, John Wiley & Sons, Ltd. Hoboken. 2004
Works (2)：
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植物性ポリフェノールの酸素添加酵素阻害に関する研究
2005 -
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ポリフェノール含有食品の酵素阻害の可能性について
2005 -
Professional career (1)：
Work history (1)：
- Okayama Prefectural University Health and Welfare Science, Department of Nutritional Science Research Assistant
Awards (1)：
Association Membership(s) (3)：
日本栄養・食糧学会
, 日本脂質生化学会
, 日本生化学会
