Yoko Ozawa

オザワヨウコ | Yoko Ozawa

Affiliation and department：
Job title： Professor
Other affiliations (1)：

Keio University School of Medicine Department of Ophthalmology Assistant Professor/Senior Assistant Professor

Homepage URL (1)： http://ophthal.med.keio.ac.jp/research/rcb.html

Research field (1)： Ophthalmology

Research keywords (1)： Neuroprotection, Aging, Oxidative stress, Inflammation

Research theme for competitive and other funds (27)：

2022 - 2025 Lipid and macrophage in age-related macular degeneration
2021 - 2024 iPS研究から発展した網膜色素変性に対する新規神経変性抑制・神経保護治療の開発
2020 - 2023 患者iPS細胞と3次元オルガノイドを用いた網膜色素変性の新規治療法に向けた解析
2020 - 2023 萎縮型加齢黄斑変性に対する小胞体ストレスに着目した新規治療法の開発
2019 - 2022 Diet regulates age-related macular degeneration

2019 - 2022 Drug screening for Retnitis pigmentosa by using reporter knock-in human iPSCs

2019 - 2022 The effect of anti-inflammatory agent, Gnetin in diabetic retinopathy

2018 - 2021 Analysis of the role of AMPK in the retina for the development of a novel treatment for atrophic age-related macular degeneration

2018 - 2021 iPS研究に基く神経変性疾患である網膜色素変性に対する新規神経保護治療法の開発

2018 - 2020 iPS細胞3次元網膜組織培養を用いた老化によるミトコンドリア障害の解析

2017 - 2020 To explore the pathogenesis of retinitis pigmentosa using the organoid system of a patient-derived iPS cells

2016 - 2019 Effect of mitochondria protection in the retinitis pigmentosa models of P23H rhodopsin mutation

2016 - 2018 Light-induced mitochondria damage and cell death in the retina

2015 - 2018 Development of a neuroprotective therapy for retinitis pigmentosa based on the iPS research

2013 - 2016 Investigation of ANGPTL2 involvement in pathogenesis of age-related macular degeneration.

2013 - 2016 Analysis of retinal degeneration caused by dysfunction of ubiquitin proteasome system

2012 - 2016 A novel device for drug delivery to the posterior segment of the eye

2012 - 2015 Roles of AMP-activated protein kinase in diabetes-induced retinal inflammation.

2012 - 2015 Angiotensin II type 1 receptor blockade suppresses light-induced neural damage in the mouse retina.

2012 - 2015 The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa

2011 - 2013 Gene correction and transplantation into pathology model marmoset of iPS cells from retinitis pimentosa patient

2011 - 2013 Influence of high fat diet in the retina

2011 - 2013 Molecular mechanisms of ocular tissue in photodynamic therapy for age-related macular degeneration

2010 - 2012 Neuroprotective effect of an antioxidant, lutein in the retina of a murine model of diabetes.

2009 - 2011 Ananlysis of the retinal degenerative diseases using iPS cells

2007 - 2008 The mechanism of photoreceptor cell differentiation to utilize in retinal regenerative therapy

2005 - 2006 網膜再生に向けた視細胞の分化メカニズムの解析

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Papers (212)：

Yoko Ozawa, Keisuke Yoshihara, Marwa Mezghani, Paulina Pierzchała, Mateusz Nikodem, Sylvaine Barbier, Mariko Nomoto, Yasuko Aitoku. Recent daily life burdens associated with neovascular age-related macular degeneration involve difficulties in use of electronic devices. Scientific reports. 2024. 14. 1. 14181-14181
Norihiro Nagai, Yasuaki Mushiga, Yoko Ozawa. Diabetic choriocapillaris flow deficits affect the outer retina and are related to hemoglobin A1c and systolic blood pressure levels. Scientific reports. 2023. 13. 1. 22570-22570
Toshiki Tezuka, Mamoru Shibata, Hironari Hanaoka, Yoshikane Izawa, Taku Kikuchi, Kunihiko Akino, Yoko Ozawa, Masataka Saito, Yuko Kaneko, Jin Nakahara, et al. Systemic lupus erythematosus mimicking retinal migraine: a case report. Cephalalgia : an international journal of headache. 2023. 43. 12. 3331024231219477-3331024231219477
Norihiro Nagai, Yasuaki Mushiga, Yoko Ozawa. Evaluating fine changes in visual function of diabetic eyes using spatial-sweep steady-state pattern electroretinography. Scientific reports. 2023. 13. 1. 13686-13686
Mariko Sasaki, Kenya Yuki, Akiko Hanyuda, Kazumasa Yamagishi, Kaoru Motomura, Toshihide Kurihara, Yohei Tomita, Kiwako Mori, Nobuhiro Ozawa, Yoko Ozawa, et al. Associations between fatty acid intake and diabetic retinopathy in a Japanese population. Scientific Reports. 2023. 13. 1

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MISC (88)：

石田晋, 小沢洋子, 近藤峰生, 園田康平, 中澤徹, 安川力, 山城健児. 専門分野の選び方,深め方. Retina Medicine. 2023. 12. 1. 1-8
石田晋, 小沢洋子, 近藤峰生, 園田康平, 中澤徹, 安川力, 山城健児. 専門分野の選び方,深め方. Retina Medicine. 2023. 12. 1. 1-8
石田晋, 小沢洋子, 近藤峰生, 園田康平, 中澤徹, 安川力, 山城健児. 人を惹きつける魅力的なプレゼンをめざそう!. Retina Medicine. 2022. 11. 1. 1-8
石田晋, 小沢洋子, 近藤峰生, 園田康平, 中澤徹, 安川力, 山城健児. 人を惹きつける魅力的なプレゼンをめざそう!. Retina Medicine. 2022. 11. 1. 1-8
石田晋, 小沢洋子, 近藤峰生, 篠島亜里, 園田康平, 中澤徹, 安川力, 柳靖雄, 山城健児. 海外からみた日本の眼科. Retina Medicine. 2021. 10. 1. 1-8

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Books (3)：

Oxidative Stress in the RPE and Its Contribution to AMD Pathogenesis: Implication of Light Exposure.
Springer Japan. 2014
Lutein and Oxidative Stress-Mediated Retinal Neurodegeneration in Diabetes
PREEDY Diabetes. 2013
Angiogenesis in Response to Hypoxia
2010

Lectures and oral presentations (53)：

Neuro-inflammation in Metabolic Syndrome.
(14th International Ocular Inflammation Society Meeting in conjunction with SOIE. 4th Assembly. 2017)
Role of Angptl2 in laser-induced CNV.
(International Retina Summit 2017)
Inflammatory responses in AMD Pathogenesis.
(32nd Asia-Pacific Academy of Ophthalmology 2017)
Case Presentations and Panel Discussion.
(11th Asia-Pacific Vitreo-retina Society (APVRS) Congress 2017)
Lutein/Zeaxanthin as a preventive approach for age-related macular degeneration.
(The 3rd International Conference on Pharma and Food. 2016)

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Education (1)：

1986 - 1992 Keio University School of Medicine

Professional career (1)：

医学博士 (慶應義塾大学)

Awards (2)：

2016 - Global Ophthalmology Awards Program Research Award
2007 - 慶應義塾大学医学部三四会奨励賞

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