Rchr
J-GLOBAL ID：200901062677303844
Update date: Sep. 20, 2024
Hashitani Hikaru
ハシタニ ヒカル | Hashitani Hikaru
Affiliation and department：
Job title：
Professor
Research field (2)：
Clinical pharmacy
, Physiology
Research keywords (4)：
下部尿路
, ペリサイト
, 細胞内カルシウム
, 平滑筋
Research theme for competitive and other funds (17)：
- 2023 - 2026 Microcontraction-afferent axis in physiology and disease of the lower urinary tract
- 2020 - 2023 骨血管機能の性差から見た循環障害に起因する骨粗鬆症の病態解明
- 2020 - 2023 蓄尿障害の主体としての膀胱粘膜下層細胞群の液性因子による制御
- 2019 - 2022 New attempt to assess the severity of sepsis due to bowel infection by focusing on the function of EDHF (Endothelial-Drived Hyperpolarizing Factor)
- 2017 - 2021 Functions of bladder muscularis mucosae during storage phase as a new therapeutic target
- 2015 - 2019 The function and relationship between interstitial cells in the detrusor bundle and smooth muscle cells
- 2014 - 2017 Is underactive bladder really downregulation of bladder contractility?
- 2012 - 2015 前立腺における収縮型線維芽細胞の生理病態機能
- 2011 - 2012 Dysfunction of multipotent pericytes as the primary cause of overactive bladder
- 2010 - 2012 Investigations into the role of uro-genital interstitial cells as a metabolic sensor in physiology and disease
- 2009 - 2011 Mechanism of neural regulation of pacemaker activity in gastric smooth muscle
- 2009 - 2010 尿路上皮下の微小循環から過活動膀胱を考える
- 2007 - 2009 Molecular physiological investigations into the commonality and heterogeneity of interstitial cells in the urogenital system
- 2007 - 2008 Voltage-dependency of pacemaker activity in gastric smooth muscle tissues
- 2005 - 2006 INVESTIGATIONS INTO THE MOLECULAR TARGETED THERAPY FOR OVERACTIVE BLADDER BY REGULATING INTERCELLULAR SIGNAL TRANSMISSION SYSTEM
- 2003 - 2004 Investigations into the spontaneous activity in smooth muscles of the lower urinary tract
- 2000 - 2001 不安定膀胱の成因としての平滑筋細胞間情報伝達の変化に関する研究
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Papers (132)：
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Hiroyuki Nakamori, Atsuko Niimi, Retsu Mitsui, Hikaru Hashitani. Lipopolysaccharide accelerates peristalsis by stimulating glucagon-like peptide-1 release from L cells in the rat proximal colon. The Journal of Physiology. 2024
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Luke Grundy, Jean J Wyndaele, Hikaru Hashitani, Bahareh Vahabi, Alan Wein, Paul Abrams, Basu Chakrabarty, Christopher H Fry. How does the lower urinary tract contribute to bladder sensation? ICI-RS 2023. Neurourology and urodynamics. 2024. 43. 6. 1293-1302
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Basu Chakrabarty, Michael Winder, Anthony J Kanai, Hikaru Hashitani, Marcus Drake, Paul Abrams, Christopher H Fry. Nitric oxide signaling pathways in the normal and pathological bladder: Do they provide new pharmacological pathways?-ICI-RS 2023. Neurourology and urodynamics. 2024. 43. 6. 1344-1352
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Retsu Mitsui, Mizuki Yamori, Hiroyuki Nakamori, Hikaru Hashitani. Stress-induced impairment of parasympathetic NO-mediated inhibition of sympathetic vasoconstriction in submucosal arteriole of rat rectum. Pflugers Archiv : European journal of physiology. 2024
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Wataru Kudo, Hikaru Hashitani. PTHrP attenuates spontaneous contractions in detrusor smooth muscle of the rat bladder by activating spontaneous transient outward potassium currents. Pflugers Archiv : European journal of physiology. 2024. 476. 5. 809-820
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MISC (23)：
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Karen D. McCloskey, Anthony Kanai, Jalesh N. Panicker, Hikaru Hashitani, Christopher H. Fry. What do we really know about the external urethral sphincter?. Continence. 2024. 10
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Richard J. Lang, Hikaru Hashitani. Role of prostatic interstitial cells in prostate motility. Journal of Smooth Muscle Research. 2017. 53. 1. 57-72
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M. J. Nguyen, R. Higashi, K. Ohta, K. -I. Nakamura, H. Hashitani, R. J. Lang. Autonomic and sensory nerve modulation of peristalsis in the upper urinary tract. AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL. 2016. 200. 1-10
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K. Lee, A. Isogai, R. Mitsui, S. Kajioka, M. Eto, H. Hashitani. FUNCTIONAL COUPLING OF TRPV4 CHANNELS AND BK CHANNELS IN REGULATING DETRUSOR SPONTANEOUS CONTRACTIONS IN THE GUINEA-PIG BLADDER. NEUROUROLOGY AND URODYNAMICS. 2016. 35. S172-S174
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T. Okinami, M. Imamura, N. Nishikawa, H. Negoro, Y. Sugino, K. Yoshimura, A. Kanematsu, H. Hashitani, O. Ogawa. GAP JUNCTION REGULATES DETRUSOR ACTIVITY IN BLADDER INFLAMMATION. NEUROUROLOGY AND URODYNAMICS. 2016. 35. S181-S182
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Education (2)：
- 1993 - 1997 Nagoya City University Graduate School of Medical Sciences
- - 1991 Kyushu University School of Medicine
Professional career (1)：
Awards (6)：
- 2014/05 - American Urological Society The Journal of Urology, Best reviewer 2014
- 2010/05 - American Urological Society The Journal of Urology, Best reviewer 2010
- 2000 - 三井生命厚生事業団 医学研究助成
- 2000 - 上原記念生命科学財団 研究奨励金
- 1997 - 上原記念生命科学財団 ポストドクトラルフェローシップ
- 1994 - 第1回日本神経因性膀胱学会学会賞
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Association Membership(s) (3)：
日本排尿機能学会
, 日本平滑筋学会
, 日本生理学会
