IIJIMA HIROSHI

イイジマヒロシ | IIJIMA HIROSHI

Affiliation and department：

Research field (3)： Functional biochemistry , Pharmaceuticals - chemistry and drug development , Biochemistry

Research keywords (6)： Chemical Biology , Structure-Activity Relationship , Molecular modeling , Protein Engineering , 創薬化学 , Medicinal Chemistry

Research theme for competitive and other funds (10)：

Show all

Papers (57)：

Tomoko Takamiya, Manako Saito, Aoi Miyamoto, Mio Oikawa, Liyue Zhang, Kazuki Yanagihashi, Erika Okawa, Yuuka Takahashi, Yui Suzuki, Misaki Watanabe, et al. BBS Gene Expression and Its Diversity in the Genus Dendrobium. Diversity. 2024. 16. 6. 337
Hiroshi Iijima. Enzyme Kinetics Based on the Concept of Flux. Chem-Bio Informatics Journal. 2024
Katsuki Takebe, Mamoru Suzuki, Takao Kuwada-Kusunose, Satoko Shirai, Kaori Fukuzawa, Tomoko Takamiya, Narikazu Uzawa, Hiroshi Iijima. Structural and Computational Analyses of the Unique Interactions of Opicapone in the Binding Pocket of Catechol O-Methyltransferase: A Crystallographic Study and Fragment Molecular Orbital Analyses. Journal of Chemical Information and Modeling. 2023
Hiroshi Iijima. 配座発生を利用した分子設計. YAKUGAKU ZASSHI. 2023. 143. 4. 369-375
Kazufusa Shinomiya, Hiroshi Iijima, Yoichiro Ito. Countercurrent chromatography as a frontier tool to discover new mechanical roles in liquid-liquid phase separation of cellular biomolecules. Biomedical Chromatography. 2023

ｍore...

MISC (13)：

武部克希, 桑田(楠瀬)隆生, 鈴木守, 飯島洋, 飯島洋. Reaction mechanism of COMT and conformational changes induced by enhancer molecules. 日本薬学会年会要旨集(Web). 2024. 144th
福澤薫, 福澤薫, 白井智子, 武部克希, 高谷大輔, 飯島洋, 飯島洋. COMT-Ligand Molecular Interactions Based on Crystal Structures and Quantum Chemical Calculations. 日本薬学会年会要旨集(Web). 2024. 144th
飯島洋, 武部克希, 鈴木守, 桑田(楠瀬)隆生, 高宮知子, 鵜澤成一. Conformational plasticity of catechol O-methyltransferase. 日本薬学会年会要旨集(Web). 2023. 143rd
飯島洋, 武部克希, 桑田(楠瀬)隆生, 鈴木守, 高宮知子, 鵜澤成一. Enhancement of COMT reaction by an enhancer compound: A crystallographic study. 日本薬学会年会要旨集(Web). 2022. 142nd
武部克希, 桑田(楠瀬)隆夫, 鈴木守, 高宮知子, 鵜澤成一, 飯島洋. Crystal structures of COMT-opicapone complex: opicapone can form stable complexes either with SAM(substrate) and SAH(Product). 日本薬学会年会要旨集(Web). 2022. 142nd

ｍore...

Patents (7)：

ｍore...

Books (6)：

ｍore...

Lectures and oral presentations (68)：

共生菌がラン科セッコク属植物のポリフェノール生合成経路に与える影響
(日本薬学会143年会 2023)
カテコールO-メチル転移酵素の配座構造の変化
(日本薬学会143年会 2023)
Investigation of hydrogen bond network in the active center of catechol O-methyltransferase by X-ray crystallography and FMO method
(2022)
ラン科セッコク属植物と共生菌の共培養を用いた物質産生系の構築
(日本薬学会142年会 2022)
賦活化化合物によるCOMTの生成物阻害の解除機構:結晶構造解析による検討
(日本薬学会142年会 2022)

ｍore...

Education (2)：

Professional career (1)：

Work history (6)：

2022/04 - 現在 Nihon University, School of Pharmacy Research Institute of Pharmacy Senior Researcher
2019/04 - 2022/03 Biofunctional Organic Chemistry Laboratory 日本大学薬学部教授
2007/07 - 2019/04 日本大学薬学部生体機能化学ユニット
1984/04 - 2007/06 キリンビール(株)
1985/10 - 1987/09 Washington University School of Medicine Postdoctoral fellow

Show all

Committee career (3)：

Awards (3)：

2015/09 - 第59回日本薬学会関東支部大会優秀ポスター賞カテコール-O-メチル転移酵素賦活化物質の構造活性相関
2005/11 - 構造活性相関シンポジウムポスター賞 Rho kinase阻害剤の分子設計
2005/01 - Best 25 downloaded article of Bioorganic Medicinal Chemistry 2004. Design and Synthesis of Rho Kinase inhibitors (I).

Association Membership(s) (3)：

日本薬学会 , 日本薬学会構造活性相関部会 , CBI学会

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page