Rchr
J-GLOBAL ID：200901063385611129
Update date: May. 01, 2024
Okano Satoshi
オカノ サトシ | Okano Satoshi
Affiliation and department：
Job title：
Lecturer of Department of Medicine
Homepage URL (1)：
https://sdgs.yamagata-u.ac.jp/project/detail_372.html
Research field (3)：
Cell biology
, Experimental pathology
, Physiology
Research keywords (14)：
mutation of CRY1 protein at zinc-binding site
, 膵δ細胞
, 膵α細胞
, chronobiology
, circadian rhythm
, pancreatic duct epithelia
, intra-islet ductal cell
, reprogramming
, pancreatic cancer
, Cellular senescence
, dedifferentiation
, DNA repair
, diabetes mellitus
, circadian clock
Research theme for competitive and other funds (18)：
- 2024 - (Grant No.27, 2024) Elucidation of the role of FSXN5 in the regulation of circadian rhythm and pancreatic β-cell function
- 2023 - 2024 (Grant No.20, 2023) Elucidation of the role of FSXN5 in the regulation of circadian rhythm and pancreatic β-cell function
- 2022 - 2023 (Grant No.29, 2022) Elucidation of β-cell dysfunction and pancreatic cancer based on the analysis of CRY1-regulated transcription factor
- 2019 - 2022 A new approach to the pathogenesis of pancreatic cancer and the disorders of circadian rhythm based on the analysis of CRY1-binding proteins
- 2021 - (Grant No.38, 2021) Elucidation of β-cell dysfunction and pancreatic cancer based on the analysis of CRY1-regulated transcription factor
- 2020 - 2021 (Grant No.10, 2020) Elucidation of β-cell dysfunction and pancreatic cancer based on the analysis of CRY1-regulated transcription factor
- 2019 - 2020 (Grant No. 8, 2019) Analyses of novel CRY1-binding proteins and the remodeling of pancreatic architecture in mutant CRY1 transgenic mice
- 2018 - 2019 (Grant No. 30, 2018) Analyses of novel CRY1-binding proteins and the remodeling of pancreatic architecture in mutant CRY1 transgenic mice
- 2017 - 2018 (Grant No.7, 2017) Analyses of novel CRY1-binding proteins and the remodeling of pancreatic architecture in mutant CRY1 transgenic mice
- 2015 - 2018 Elucidation the roles of senescence-like phenotype in pancreatic beta-cells in diabetic mutant cryptochrome1 transgenic mice
- 2015 - 2016 (Grant No.3, 2016) Elucidation of diabetes and rhythm disorder in mutant CRY1 transgenic mice using proteomics approach
- 2014 - 2015 (Grant No.6, 2015) Elucidation of diabetes and rhythm disorder in mutant CRY1 transgenic mice using proteomics approach
- 2012 - 2015 Elucidation of molecular mechanisms of unusual circadian locomotor behavior and non-obese early onset diabetes mellitus in mutant (Cys414-Ala) cryptochrome1 transgenic mice
- 2013 - 2014 (Grant No.30, 2015) Elucidation of diabetes and rhythm disorder in mutant CRY1 transgenic mice using proteomics approach
- 2009 - 2011 Analysis of diabetes mellitus in mutant cryptochrome1 transgenic mice
- 2008 - 2009 Chronobiological analysis of circadian locomotive behaviors of mutant CRY1 mice
- 2006 - 2008 Analysis of the physiological roles of carbon monoxide in the regulation of circadian clock
- 2004 - 2006 Chronobiological approach to the physiological functions of heme
Show all
Papers (18)：
-
Okano S, Yasui A, Kanno S, Satoh K, Igarashi M, Nakajima O. Karyopherin alpha 2-expressing pancreatic duct glands and intra-islet ducts in aged diabetic C414A-mutant-CRY1 transgenic mice. Journal of Diabetes Research. 2019. Volume 2019. Article ID 7234549-7234549
-
Takujiro Homma, Ryusuke Akihara, Satoshi Okano, Mototada Shichiri, Yasukazu Yoshida, Ken-ichi Yamada, Satoshi Miyata, Osamu Nakajima, Junichi Fujii. Heightened aggressive behavior in mice deficient in aldo-keto reductase 1a (Akr1a). BEHAVIOURAL BRAIN RESEARCH. 2017. 319. 219-224
-
Satoshi Okano, Akira Yasui, Kiyoshi Hayasaka, Osamu Nakajima. Unique food-entrained circadian rhythm in cysteine414-alanine mutant mCRY1 transgenic mice. SLEEP AND BIOLOGICAL RHYTHMS. 2016. 14. 3. 261-269
-
Satoshi Okano. Unique Aspects of Cryptochrome in Chronobiology and Metabolism, Pancreatic beta-Cell Dysfunction, and Regeneration: Research into Cysteine414-Alanine Mutant CRY1. JOURNAL OF DIABETES RESEARCH. 2016. 2016. Article ID 3459246, 9 pages
-
Takujiro Homma, Satoshi Okano, Jaeyong Lee, Junitsu Ito, Noriyuki Otsuki, Toshihiro Kurahashi, Eun Sil Kang, Osamu Nakajima, Junichi Fujii. SOD1 deficiency induces the systemic hyperoxidation of peroxiredoxin in the mouse. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2015. 463. 4. 1040-1046
ｍore...
MISC (14)：
-
Satoshi Okano. New findings on pancreatic endocrine cell neogenesis from precancerous lesions of pancreatic cancer in mice expressing Zn-binding deficient CRY1. Precision Medicine - Autoimmune liver diseases; etiology, diagnosis and treatment -. 2023. 6. 14. 63-67
-
Satoshi Okano. Overexpression of zinc-binding deficient Cryptochrome induces anomalous circadian rhythms, Transdifferentiation among pancreatic endocrine cells in diabetic mutant CRY1 transgenic mice. Precision Medicine - Circadian precision medicine -. 2023. 6. 5. 60-64
-
Satoshi Okano. Overexpression of zinc-binding deficient Cryptochrome induces anomalous circadian rhythms, disorders in pancreatic β-cells and precursor lesions of pancreatic ductal adenocarcinoma. A new development of hypoxia biology. 2022. 54. 7. 58-68
-
Satoshi Okano. Possible involvement of microRNAs in the generation of aberrant intra-islet ducts in mutant CRY1 transgenic mice. Agricultural biotechnology - The science of nature therapy -. 2021. 5. 13. 1199-1203
-
Satoshi Okano. Medical Science Digest - Recent advances in pancreatic cancer practice -. Medical Science Digest - Recent advances in pancreatic cancer practice -. 2021. 47. 7. 390-392
ｍore...
Lectures and oral presentations (66)：
-
Regeneration of pancreatic alpha-cells from intra-islet ducts in zinc-binding site-mutated CRY1 expressing diabetic mice
(The 54th Annual Meeting of Japan Pancreas Society 2023)
-
Possible alpha-cell regeneration from mucin-producing ducts in zinc-binding site-mutated CRY1-expressing diabetic mice (291-LB)
(83rd Scientific Sessions American Diabetes Association (ADA) 2023)
-
Features of epithelial mesenchymal transition in dedifferentiated pancreatic β-cell line MIN6 cells
(The 45th Annual Meeting of the Molecular Biology Society of Japan (MBSJ2022) 2022)
-
Molecular circadian clock and epithelial mesenchymal transition-like phenotype in dedifferentiated pancreatic β-cell line MIN6 cells
(The 20 th Sapporo Symposium on Biological Rhythm in 2022 2022)
-
Molecular circadian clock and β-cell dedifferentiation in MIN6 cells
(The 26th International Association of Pancreatology (IAP), The 53rd Annual Meeting of Japan Pancreats Society (JPS) 2022)
ｍore...
Education (3)：
- 1993 - 1996 Osaka University Graduate School of Engineering Science Department of Biophysical Engineering
- 1991 - 1993 Yamaguchi University Graduate School of Science Department of Biology
- 1987 - 1991 Yamaguchi University Faculty of Science Department of Biology
Professional career (1)：
Work history (9)：
- 2017/04 - 現在 Graduate School of Medical Science, Yamagata University, Lecturer of Department of Medicine
- 2013/04 - 現在 Yamagata Kousei School of Nursing, Part-time Lecturer
- 2013/04 - 現在 Tohoku University Institute of Development, Aging and Cancer (IDAC) Joint Researcher
- 2014/01 - 2017/03 Yamagata University Institute for Promotion of Medical Science Research, Faculty of Medicine Lecturer of Department of Medicine
- 2011/04 - 2013/12 Yamagata University Research Laboratory for Molecular Genetics, Faculty of Medicine Lecturer of Department of Medicine
- 2007/04 - 2011/03 Yamagata University Research Laboratory for Molecular Genetics, Faculty of Medicine Assistant Professor
- 2003/04 - 2007/03 Yamagata University Research Laboratory for Molecular Genetics Assistant Professor
- 1998/10 - 2003/03 Tohoku University Institute of Development, Aging and Cancer (IDAC) Researcher
- 1996/10 - 1998/09 RIKEN Photodynamics Research Center Researcher
Show all
Awards (4)：
- 2016/03 - Yamagata Univ. Research on mutant mCRY1, islet function, and food-entrained circadian rhythm, Research Award
- 2013/03 - Yamagata Univ. Research on Cysteine414-Alanine mutant mCRY1 and beta-cell dysfunction, Research Award
- 2010/05 - The 53th Annual Meeting of the Japan Diabetes Society Presidential Poster Winner (President: Prof. Kohei Kaku) Non-obese early onset diabetes in mutant CRY1 transgenic mice.
- 2004/01 - Institute of Development, Aging and Cancer (IDAC), Tohoku University IDAC Research Award Elucidation of mechanisms for DNA repair of single-strand breaks in human cells by visualization of spatial and temporal assembly of repair proteins to damage sites.
Association Membership(s) (7)：
JAPAN PANCREAS SOCIETY
, THE JAPANESE BIOCHEMICAL SOCIETY
, JAPANESE SOCIETY OF ANTI-AGING SOCIETY
, THE JAPAN DIABETES SOCIETY
, JAPANESE SOCIETY FOR CHRONOBIOLOGY
, THE JAPANESE RADIATION RESEARCH SOCIETY
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
