Rchr
J-GLOBAL ID：200901063396558394   Update date: Jan. 31, 2024

Hosokawa Nobuko

ホソカワ ノブコ | Hosokawa Nobuko
Affiliation and department：
Kyoto University Institute for Frontier Life and Medical Sciences

About Kyoto University Institute for Frontier Life and Medical Sciences


Job title： Associate Professor
Research field  (3)： Medical biochemistry ,  Cell biology ,  Molecular biology
Research keywords  (6)： 生化学 ,  分子生物学 ,  細胞生物学 ,  Biochemistry ,  Molecular Biology ,  Cell Biology
Research theme for competitive and other funds  (19)：
  • 2018 - 2021 Study on the intracellular transsport mechanism of collagens
  • 2014 - 2017 Study on the protein quality control mechanism in the endoplasmic reticulum
  • 2010 - 2012 Analysis of the ubiquitin-ligase complex in the endoplasmic reticulum membrane that regulates endoplasmic reticulum-associated degradation in mammals
  • 2010 - 2011 レクチンとシャペロンを介した小胞体タンパク質の品質管理
  • 2007 - 2011 Quality control mechanism of misfolded proteins
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Papers (64)：
  • Yukihiro Hirata, Yuto Matsui, Ikuo Wada, Nobuko Hosokawa. Endoplasmic reticulum-to-Golgi trafficking of procollagen III via conventional vesicular and tubular carriers. Molecular Biology of the Cell. 2022. 33. 3
  • Tokuya Hattori, Ken Hanafusa, Ikuo Wada, Nobuko Hosokawa. SEL1L degradation intermediates stimulate cytosolic aggregation of polyglutamine-expanded protein. The FEBS Journal. 2021
  • Matsui Y, Hirata Y, Wada I, Hosokawa N. Visualization of procollagen IV reveals ER-to-Golgi transport by ERGIC-independent carriers. Cell Structure and Function. 2020. 45
  • HOSOKAWA Nobuko. In vitro Mannosidase Assay of EDEMs: ER Degradation-Enhancing α-Mannosidase-Like Proteins. Lectin Purification and Analysis: Methods and Protocols. 2020
  • Hanafusa K, Wada I, Hosokawa N. SDF2-like protein 1 (SDF2L1) regulates the endoplasmic reticulum localization and chaperone activity of ERdj3 protein. Journal of Biological Chemistry. 2019. 294. 19335-19348
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MISC (61)：
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Books (16)：
  • ERAD(小胞体関連分解)を制御するレクチンOS-9とXTP3-B.
    日本生化学会 2011
  • N.: Isolation and binding assay of EDEMs
    GlycoPOD web site(Ed. T. Kawasaki): <9>-9(2011) 2011
  • Mannose 6-phosphate receptor homology domain-containing lectins in mammalian endoplasmic reticulum-associated degradation.
    Methods in Enzymology: 480 (Ed. M. Fukuda) Elsevier, 181-197 2010
  • M-type lectins as novel components of secretory pathways.
    “Animal Lectins: A Functional View” (Eds. G. R. Vasta, H. Ahmed) CRC Press, 165-169 2009
  • キーワード:タンパク質の一生 (編集:遠藤斗志也、小椋光、永田和宏、田口英樹、吉田賢右)
    蛋白質核酸酵素 Vol. 53, No.8、分担 2008
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Lectures and oral presentations  (27)：
  • ERp46 triggers mannose trimming activity of EDEM3.
    (International Symposium on ER stress, glycosylation, homeostasis and diseases 2018)
  • 小胞体関連分解を担うHRD1-SEL1Lユビキチンリガーゼ複合体の機能解析
    (第34回日本糖質学会年会 2015)
  • 小胞体膜におけるプロテオスタシス維持機構
    (第36回日本分子生物学会年会ワークショップ「ER・Post-ERにおける膜プロテオスタシスネットワーク研究の新展開」 2013)
  • Homeostasis and quality control of proteins in cells
    (The Joint Symposium of the 7th International Symposium of the Institute Network and the 45th IDAC Symposium, the 2nd Symposium for Joint Usage/Research Center of Aging. “Research Frontiers for Smart Aging” (仙台市) 2012)
  • Roles of N-glycans in the regulation of mammalian glycoprotein quality control
    (第34回日本分子生物学会年会回日本分子生物学会年会シンポジウム「Glycoprotein quality control: Biosynthesis, moelecular recognition and physiological roles of N-glycans」 2011)
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Education (4)：
  • 1988 - 1992 Kyoto Prefectural University of Medicine Graduate School, Division of Medicine
  • - 1992 Kyoto Prefectural University of Medicine
  • - 1984 Kyoto Prefectural University of Medicine
  • - 1984 Kyoto Prefectural University of Medicine Faculty of Medicine
Professional career (1)：
  • Doctor of Medicine (Kyoto Prefectural University of Medicine)
Association Membership(s) (3)：
日本生化学会 ,  日本分子生物学会 ,  日本細胞生物学会
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