Ishigami Akihito

2015 - 2019 Development of early clinical reagents for Alzheimer's disease using citrullinated proteins as index

2015 - 2018 Effects of simultaneous deficiency of vitamins C and E on memory, learning behavior, lipid metabolism, aging and age-associated disease

2014 - 2018 MicroRNAs associated with smoking-induced pulmonary emphysema in senescence marker protein-30 knockout mice

2014 - 2018 Establishment of treatment strategy of elderly rheumatoid arthritis based on treat-to-target strategy, Peptidylarginine Deiminase 4, and single nucleotide polymorphisms

2014 - 2017 Influences of Exercise after Arterial Ligation on Oxidative Stress and Pro-angiogenic Factors - Using a Mouse Model of Lower limb Ischemia -

2014 - 2017 A new endocrinological mechanism of septic shock and vitamin C supplementation in septic shock under real-time vitamin C monitoring with electron spin resonance spectroscopy

2014 - 2016 アルツハイマー型認知症の発症や神経細胞傷害に及ぼす蛋白質シトルリン化の病理解析

2012 - 2015 Development of amyloid beta aggregation inhibitor for therapeutics of Alzheimer disease

2012 - 2015 A novel strategy for heart failure by anti-aging

2012 - 2015 Development of diagnostic agent for dementia

2012 - 2015 Effect of vitamin C deficiency on the fetal growth and aging

2011 - 2013 The role of senescence marker protein-30 (SMP30) in the progression of diabetic nephropathy

2009 - 2011 Pathological analysis of PAD and citrullinated proteins that triggers the onset of Alzheimer's disease

2009 - 2011 Role of SMP30 in the development of heart failure

2009 - 2011 Pathogenesis and drug development using a mouse model of chronic obstructive pulmonary disease

2008 - 2010 Role of Senescence Marker Protein-30in Glucose Homeostasis

2007 - 2008 Influence of vitamin C deficiency exerts on aging, nervous system, energy metabolism and lipid metabolism

2007 - 2008 Analysis of pathogenic mechanisms of myasthenia gravis.

2007 - 2008 Elucidation of the mechanism for the development of chronic obstructive pulmonary disease (COPD) by using vitamin C deficient mice

2006 - 2007 The elucidation of onset mechanism of Alzheimer's disease.

2005 - 2006 Pathological analysis of abnormal activation for peptidylarginine deiminase in brain

2003 - 2005 The elucidation of the apoptosis inhibitory action of SMP30.

2002 - 2004 Molecular pathological analysis of citrullinated proteins in the brain from neurodegenerative disorder patients.

1995 - 1996 Functional Significance of Protein Deimination during the Cornification of Epidermis

1994 - 1994 皮膚の防御機能の老化とタンパク質の脱イミノ化

Functional analysis of peptidylarginine deiminase (PAD)

Citrullinated protein and Alzheimer's disease

Senescence marker protein-30 (SMP30) and age-associated organ disorders

Biomarkers of aging and their clinical applications

Vitamin C and aging