Rchr
J-GLOBAL ID：200901064616097500
Update date: Dec. 19, 2024
Magari Masaki
マガリ マサキ | Magari Masaki
Affiliation and department：
Job title：
Assistant Professor
Homepage URL (1)：
https://www.okayama-u.ac.jp/user/saibou/
Research field (3)：
Functional biochemistry
, Applied biofunctional and bioprocess engineering
, Immunology
Research keywords (9)：
Germinal center
, Follicular dendritic cell
, B cell
, 機能生物学
, 細胞生物学
, 免疫学
, Functional Biochemistry
, Cell Biology
, Immunology
Research theme for competitive and other funds (22)：
- 2024 - 2027 抗体産生を促進する因子探索からワクチン強化技術への展開
- 2023 - 2025 抗体産生を増強する因子探索によるワクチン強化技術への展開
- 2021 - 2024 リンパ節由来ストローマ細胞株を用いる人工リンパ節構築系の開発
- 2021 - 2024 CaMKKシグナル伝達の制御機構解明とそれに基づく分子標的薬創製
- 2022 - 2023 抗体産生を増強する因子解明によるワクチン強化技術の開発
- 2020 - 2022 免疫機能を内包する人工リンパ節の構築
- 2018 - 2021 Estanblishment of cell cuture system to reproduce affinty maturaton of antiby
- 2018 - 2021 Regulation of CaMKKbeta/AMPK signaling and drug development
- 2021 - 2021 免疫調節剤の開発に向けた抗体産生能力評価系の構築
- 2019 - 2020 リンパ節ストローマ細胞を用いる人工リンパ組織の構築
- 2019 - 2020 二次リンパ組織由来ストローマ細胞株を用いる人工リンパ節構築系の開発
- 2015 - 2019 Improvement of an animal cell-displaying technology by using a splicing factor
- 2014 - 2017 Phosphorylation-dependent regulatory mechanism of calmoudlin-kinase cascade
- 2015 - 2016 In vitro細胞培養系を利用する抗体の親和性成熟機構の解明
- 2013 - 2016 Elucidating the activation mechanisms of germinal center B cell induced by monocytic cells depending on follicular dendritic cells.
- 2014 - 2015 濾胞樹状細胞による抗体の親和性成熟の制御メカニズムの解明
- 2012 - 2015 Antibody engineering in a hypermutaing B cell line
- 2012 - 2015 Identification of a new type of monocytic cell that promotes affinity maturation and characterization of its B cell-activation mechanism
- 2011 - 2012 Analysis of selection mechanisms of germinal center B cells by using a novel follicular dendritic cell line
- 2009 - 2011 Analysis of affinity maturation process of antibodies using a novel FDC line and its application.
- 2009 - 2010 Establishment of a novel chicken monoclonal antibody generation system for applying to antibody drug development.
- 2004 - 2005 抗体遺伝子再構成を行ったB細胞を検出する新規可視化法の確立
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Papers (62)：
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Akari Yoshida, Satomi Ohtsuka, Fumiya Matsumoto, Tomoyuki Miyagawa, Rei Okino, Yumeya Ikeda, Natsume Tada, Akira Gotoh, Masaki Magari, Naoya Hatano, et al. Development of a novel AAK1 inhibitor via Kinobeads-based screening. Scientific reports. 2024. 14. 1. 6723-6723
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Satomi Ohtsuka, Yumi Miyai, Hiroyuki Mima, Masaki Magari, Yoichi Chiba, Futoshi Suizu, Hiroyuki Sakagami, Masaki Ueno, Hiroshi Tokumitsu. Transcriptional, biochemical, and immunohistochemical analyses of CaMKKβ/2 splice variants that co-localize with CaMKIV in spermatids. Cell Calcium. 2024. 102820-102820
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Kento Nlandu Nakamura, Haruki Yamauchi, Hiroyuki Mima, Yerun Chen, Satomi Ohtsuka, Masaki Magari, Ryo Morishita, Hiroshi Tokumitsu. Rapid detection of calmodulin/target interaction via the proximity biotinylation method. Biochemical and biophysical research communications. 2023. 659. 29-33
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Masaki Magari, Miku Nishioka, Tomomi Hari, Sayaka Ogawa, Kaho Takahashi, Naoya Hatano, Naoki Kanayama, Junichiro Futami, Hiroshi Tokumitsu. The immunoreceptor SLAMF8 promotes the differentiation of follicular dendritic cell-dependent monocytic cells with B cell-activating ability. FEBS letters. 2022
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Riku Kaneshige, Satomi Ohtsuka, Yuhei Harada, Issei Kawamata, Masaki Magari, Naoki Kanayama, Naoya Hatano, Hiroyuki Sakagami, Hiroshi Tokumitsu. Substrate recognition by Arg/Pro-rich insert domain in calcium/calmodulin-dependent protein kinase kinase for target protein kinases. The FEBS Journal. 2022
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MISC (58)：
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川俣一晟, 美馬光志, 山内陽生, 北前勝哉, 山内香奈, 大塚里美, 曲正樹, 金山直樹, 徳光浩. CaMKKの基質認識機構の解明と特異的阻害分子開発への応用. 日本生化学会大会(Web). 2022. 95th
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大塚里美, 波多野直哉, 奥村太晟, 澤直樹, 田邊史子, 傳田美和子, 金山直樹, 曲正樹, 森下了, 石川彰彦, et al. CaMKK阻害剤(TIM-063)を用いた阻害剤プロテオミクス解析. 日本生化学会大会(Web). 2021. 94th
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Magari Masaki, Ogawa Sayaka, Matsuoka Yukiko, Takada Miho, Kanayama Naoki, Tokumitsu Hiroshi. ヘルスシステムの理解とその応用 濾胞樹状細胞による抗体の親和性成熟の制御機構の解明(Interdisciplinary Science and Engineering in Health Systems Immunological functions of follicular dendritic cells on affinity maturation of antibody). 生物物理. 2018. 58. Suppl.1-2. S197-S197
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N. Kanayama, Y. Kawaguchi, N. Kawamoto, H. Nariki, S. Miyazaki, K. Yokoyama, M. Magari, H. Ohmori, H. Tokumitsu. SRSF1-3 has a role in nuclear localization of AID by regulating its nuclear export. EUROPEAN JOURNAL OF IMMUNOLOGY. 2016. 46. 1142-1142
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Y. Kawaguchi, K. Yokoyama, N. Kawamoto, H. Nariki, Y. Matsuyama, Y. Kanehiro, T. Hikasa, M. Magari, H. Ohmori, H. Tokumitsu, et al. Analysis of a role for SRSF1-3 in a transcription-coupled process during IgV hypermutation. EUROPEAN JOURNAL OF IMMUNOLOGY. 2016. 46. 1267-1268
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Patents (1)：
Lectures and oral presentations (203)：
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BAFFはB細胞活性化能を有する単球系細胞の分化を促進する
(第47回日本分子生物学会年会 2024)
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濾胞樹状細胞の発現するSLAMF5によるB細胞の機能調節
(第47回日本分子生物学会年会 2024)
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CaMKKオリゴマー形成の分子機構
(第47回日本分子生物学会年会 2024)
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B細胞活性化能を有する単球系細胞の分化機構の解明
(第97回 日本生化学会大会 2024)
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CaMKKβの新たな酵素活性調節機構の解明に向けた生化学的解析
(第97回 日本生化学会大会 2024)
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Education (4)：
- - 2002 Okayama University
- - 2002 Okayama University Graduate School, Division of National Science and Technology System Science
- - 1998 Okayama University Faculty of Engineering
- - 1998 Okayama University Faculty of Engineering
Professional career (1)：
- Doctor(Engineering) (Okayama University)
Work history (2)：
- 2002 - - 岡山大学自然科学研究科 助教
- 2002 - - Assistant Professor,Graduate School of Natural Science and Technology,Okayama University
Awards (7)：
Association Membership(s) (6)：
Society for Leukocyte Biology
, 日本分子生物学会
, 日本免疫学会
, 日本生物工学会
, Society for Leukocyte Biology
, 日本生化学会
