Rchr

J-GLOBAL ID：200901064796827366 Update date: Feb. 01, 2024

Tezuka Tohru

テヅカトオル | Tezuka Tohru

Affiliation and department：

Research field (3)： Cell biology , Functional biochemistry , Neuroscience - general

Research keywords (4)：神経系 , ユビキチン化 , チロシンキナーゼ , Tyrosine kinase

Research theme for competitive and other funds (10)：

2009 - 2009 Roles of Dok-7 and MuSK in neuromuscular synaptogenesis
2006 - 2007 Src及びCblファミリーによるチロシンリン酸化シグナルの正負の制御と脳高次機能
2004 - 2005 Elucidation of roles of Cbl-family proteins in the nervous system.
2004 - 2004 Src及びCblファミリーによるチロシンキナーゼシグナルの正負の制御と脳高次機能
2003 - 2003 Src及びCblファミリーによるチロシンキナーゼシグナルの正負の制御と脳高次機能

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Papers (47)：

Sadanori Miyoshi, Tohru Tezuka, Sumimasa Arimura, Taro Tomono, Takashi Okada, Yuji Yamanashi. DOK7 gene therapy enhances motor activity and life span in ALS model mice. EMBO MOLECULAR MEDICINE. 2017. 9. 7. 880-889
Ryo Ueta, Tohru Tezuka, Yosuke Izawa, Sadanori Miyoshi, Satoru Nagatoishi, Kouhei Tsumoto, Yuji Yamanashi. The carboxyl-terminal region of Dok-7 plays a key, but not essential, role in activation of muscle-specific receptor kinase MuSK and neuromuscular synapse formation. JOURNAL OF BIOCHEMISTRY. 2017. 161. 3. 269-277
Eguchi T, Tezuka T, Miyoshi S, Yamanashi Y. [Molecular mechanisms underlying the formation and maintenance of neuromuscular junctions and a possible therapeutic approach.]. Clinical calcium. 2017. 27. 3. 413-419
Takahiro Eguchi, Tohru Tezuka, Sadanori Miyoshi, Yuji Yamanashi. Postnatal knockdown of dok-7 gene expression in mice causes structural defects in neuromuscular synapses and myasthenic pathology. GENES TO CELLS. 2016. 21. 6. 670-676
Tohru Tezuka, Akane Inoue, Taisuke Hoshi, Scott D. Weatherbee, Robert W. Burgess, Ryo Ueta, Yuji Yamanashi. The MuSK activator agrin has a separate role essential for postnatal maintenance of neuromuscular synapses. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014. 111. 46. 16556-16561

ｍore...

MISC (4)：

Education (3)：

- 1998 The University of Tokyo
- 1998 The University of Tokyo Graduate School, Division of Science
- 1993 The University of Tokyo Faculty of Science

Professional career (1)：

博士 (東京大学)

Work history (1)：

The University of Tokyo The Institute of Medical Science, Division of Oncology, Division of Oncology, Department of Cancer Biology Div. Genetics, Inst. Med Sci., Univ. Tokyo

Association Membership(s) (3)：

Society for Neuroscience , 日本分子生物学会 , Society for Neuroscience

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