Rchr
J-GLOBAL ID:200901064874931370
Update date: Sep. 28, 2024
Itabe Hiroyuki
イタベ ヒロユキ | Itabe Hiroyuki
Affiliation and department:
Job title:
Professor
Homepage URL (1):
http://www10.showa-u.ac.jp/~biolchem/
Research field (3):
Metabolism and endocrinology
, Cell biology
, Pharmaceuticals - health and biochemistry
Research keywords (5):
intracellular lipid droplets
, mass spectrometry
, atherosclerosis
, liipid metabolism
, 生化学
Research theme for competitive and other funds (42):
- 2023 - 2026 Mitochondrial dysfunction in proximal tubular epithelial injury of Anti–brush border antibody disease
- 2022 - 2025 Novel approach to search for factors regulating intracellular lipid droplet formation based o Sar1b function.
- 2019 - 2022 Oxidatively modified high-density lipoprotein: its roles in vessel wall tissues and mechanism of its generation.
- 2018 - 2019 平滑筋細胞に起因する新たな動脈硬化進展メカニズムの解析とその抑制方法の構築
- 2016 - 2019 Proinflammatory activity elicited by oxidized low-density lipoproteins and neutrophil extracellular trap formation
- 2016 - 2018 Comprehensive analysis of protein in gingival crevicular fluids and its association with neutrophil extracellular trap
- 2015 - 2018 酸化LDLの生体内での生成・代謝過程の解明:安定同位体標識リピドミクスの応用
- 2014 - 2016 Comprehensive analysis of protein in gingival crevicular fluids from deciduous and permanent teeth using LC-ESI-MS/MS quantitative proteomics
- 2012 - 2015 酸化ストレス・病態マーカーとなる酸化リン脂質の高感度定量系の構築
- 2010 - 2014 新たなバイオマーカー探索を目指した先端的薬学研究
- 2011 - 2012 血管平滑筋細胞の抗酸化システム・抗炎症システム変動による動脈硬化発症機構
- 2009 - 2012 動脈硬化症の原因となる発症初期の血漿酸化LDLの生成機序解明とその抑制
- 2009 - 2010 動脈硬化発症過程における酸化イベントの発生と平滑筋細胞応答に関する研究
- 2009 - 2010 Analysis of modified low-density lipoproteins in plasma of myocardial infarction
- 2007 - 2009 生活習慣病原因解明の基盤となる構造体である細胞内脂肪滴の生物薬学的研究
- 2005 - 2008 生活習慣病の危険因子の解明と治療
- 2005 - 2006 動脈硬化症進展の抑制における多様な細胞ストレスに関する研究
- 2004 - 2006 免疫学的手法による生体内酸化LDLの分離とその性状解析
- 2005 - 2006 Usefulness of plasma oxidative biomarker in patients with acute cerebral infarction
- 2004 - 2005 マクロファージ細胞内脂肪滴の形成と消滅の機構に関する研究
- 2002 - 2005 Foam cell rupture may involve in the development of atheroma
- 2003 - 2004 Imbalance between Oxidant/Antioxidant Systems Contributes to Plaque Vulnerability in Patients with Carotid Stenosis
- 2001 - 2003 生体内型酸化LDLの変性構造・生物活性の解析と酸化LDL最適モデルの検索
- 1999 - 2001 酸化LDL中の活性因子である酸化リン脂質の生体内での生成と代謝
- 2000 - 2001 Oxidized lipoproteins released from atherosclerotic lesions
- 2000 - 2001 Pathohistological and biochemical analysis in carotid plaque
- 1998 - 2001 Novel diagnosis of oxidized LDL in serum using monoclonal antibody
- 1999 - 2000 動脈硬化発症要因である酸化PCおよび酸化PC-蛋白複合体の代謝と認識機構
- 1998 - 1999 動脈硬化時における過酸化脂質の役割
- 1997 - 1999 モノクローナル抗体を用いた泡沫細胞内および血中の酸化LDL代謝様式の研究
- 1998 - 1999 Metabolism of Oxidized Low Density Lipoprotein by Lecithin-Colesterol Acyltransferse
- 1997 - 1998 マクロファージの泡沫化に伴う細胞活性変化と泡沫細胞内物質代謝の解析
- 1996 - 1997 抗酸化PC抗体を用いたLDLの酸化変性と泡沫細胞内酸化LDL代謝の研究
- 1995 - 1997 Transcriptional regulation of intracellular cholesterol metabolism
- 1995 - 1996 モノクローナル抗体を用いた酸化LDL微量定量法と泡沫細胞内酸化LDL代謝の研究
- 1994 - 1996 Monoclonal Antibody Recognizing Peroxidized Lipoproteins Accumulated in Atherosclerotic Lesion.
- 1994 - 1995 抗酸化LDLモノクローナル抗体を用いた泡沫細胞内酸化LDLの代謝様式の解析
- 1993 - 1994 酸化LDLを特異的に認識するモノクローナル抗体による酸化LDLの構造と機能の解析
- 1992 - 1994 Attempts for contruction of arterial wall with medial smooth muscle cells in vitro -An approach foam developmental biology-
- 1992 - 1993 過酸化リポタンパク質認識モノクローナル抗体を用いた過酸化LDLの構造と生理機能の解析
- 1991 - 1993 A novel monoclonal antibody recognizing extracellular space of the atherosclerotic lesions in WHHL rabbits.
- Study on the mechanism of atherogenesis.
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Papers (223):
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Hitomi Ohinata, Wiraphol Phimarn, Mirei Mizuno, Takashi Obama, Kiyoshi Fukuhara, Tomohiko Makiyama, Yuichi Watanabe, Hiroyuki Itabe. Suppressive effect of resveratrol, catechin and their conformationally constrained analogs on neutrophil extracellular trap formation by HL-60-derived neutrophils. Journal of Clinical Biochemistry and Nutrition. 2024. 75. 1. 17-23
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Tomohiko Makiyama, Takashi Obama, Yuichi Watanabe, Masahiro Chatani, Yuki Azetsu, Kosuke Kawaguchi, Tsuneo Imanaka, Hiroyuki Itabe. Behavior of intracellular lipid droplets during cell division in HuH7 hepatoma cells. Experimental cell research. 2023. 433. 2. 113855-113855
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Hitomi Ohinata, Takashi Obama, Tomohiko Makiyama, Yuichi Watanabe, Hiroyuki Itabe. High-Density Lipoprotein Suppresses Neutrophil Extracellular Traps Enhanced by Oxidized Low-Density Lipoprotein or Oxidized Phospholipids. International Journal of Molecular Sciences. 2022. 23. 22. 13992-13992
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Matsuo Yamamoto, Marika Sugano, Hiroyuki Itabe. The Etiological Consideration of Oxidized Low-Density Lipoprotein in Periodontitis. Journal of oral biosciences. 2022. 65. 1. 19-23
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Tomohiko Makiyama, Takashi Obama, Yuichi Watanabe, Hiroyuki Itabe. Sar1 Affects the Localization of Perilipin 2 to Lipid Droplets. International Journal of Molecular Sciences. 2022. 23. 12. 6366-6366
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MISC (131):
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KANG Dedong, 高木孝士, 相内敏弘, 板部洋之, 矢持淑子, 本田浩一, 本田一穂. Proximal renal tubular injury in glomerulonephritis by proteomic analysis. 日本病理学会会誌. 2023. 112. 1
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澤田直子, 板部洋之, 小浜孝士, 木庭新治, 巖本三壽, 高木孝士, フィマーン ウィラポール, 牧山智彦, 相内敏弘. HDLを伴った血中酸化リポタンパク質粒子の生成と動脈硬化症. 日本生化学会大会(Web). 2020. 93rd
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Takashi Obama, Hiroyuki Itabe. Atherosclerosis and NETs: Synergistic effect of oxidized LDL. Thrombosis Medicine. 2019. 9. 4. 285-91
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小浜孝士, 大日方瞳, 高木孝士, 澤田直子, 相内敏弘, 板部洋之. 好中球細胞外トラップ形成を介した酸化LDLの血管内皮細胞炎症誘導. Pharmaco-Hematologyシンポジウム講演要旨集. 2019. 20th
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小濱孝士, 大日方瞳, 高木孝士, 澤田直子, 相内敏弘, 板部洋之. 酸化LDLによる好中球細胞外トラップ形成促進と血管内皮細胞の応答. 脂質生化学研究. 2019. 61
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Books (22):
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詳解生化学 : biochemistry
京都廣川書店 2020 ISBN:9784909197672
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Biochemistry
2015
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酸化ストレスの医学 改訂第2版
診断と治療社 2014
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試料分析講座4巻 脂質
丸善 2011
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コレステロール---基礎から臨床へ---
ライフサイエンス出版 2009
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Education (5):
- 1988 - Gradulate School, The University of Tokyo
- 1983 - 1987 Graduate School, The University of Tokyo Faculty of Pharmaceutical Sciences
- - 1987 The University of Tokyo Graduate School, Division of Pharmaceutical Sciences
- 1979 - 1983 The University of Tokyo Faculty of Pharmaceutical Sciences
- - 1983 The University of Tokyo Faculty of Pharmaceutical Science
Professional career (1):
- (BLANK) (The University of Tokyo)
Work history (10):
- 2018/04 - 現在 Showa University Division of Biological Chemistry, Department of Pharmaceutical Sciences, School of Pharmacy Professor
- 2004/04 - 2018/03 Showa University Department of Biologocal Chemisty、Faculty of Pharmaceutical Sciences Professor
- 2000/04 - 2004/03 Teikyo University Department of Molecular Pathology, Facaulty ofo Pharmaceutical Sciences Associate professor
- 1997 - 2000 Teikyo University, Assistant Professor
- 1997 - 2000 Teikyo University Faculty of Pharma-Science
- 2000 - Teikyo University, Associate Professor
- 1991 - 1997 Teikyo University Faculty of Pharma-Science
- 1988 - 1991 The University of Tokyo
- 1988 - 1991 The University of Tokyo, Research Assistant
- 1991 - -1197 Teikyo University, Research Assistant
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Committee career (2):
- 2001 - 日本生化学会 関東支部会幹事
- 1999 - 日本動脈硬化学会 評議員
Awards (4):
- 2011 - Society for Free Radical Research Japan Academic Award
- 2001 - 日本薬学会学術振興賞
- 2000 - 日本生化学会 JB論文賞
- 2000 - 日本動脈硬化学会 第8回若手研究者奨励賞
Association Membership(s) (5):
SOCIETY FOR FREE RADICAL RESEARCH JAPAN
, 日本動脈硬化学会
, 日本脂質生化学会
, 日本薬学会
, 日本生化学会
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