J-GLOBAL ID:200901065184059730   Update date: Dec. 19, 2019


クスハラ ヒロユキ | KUSUHARA Hiroyuki
Affiliation and department:
Job title: Associate Professor
Homepage URL  (1): http://www.f.u-tokyo.ac.jp/~molpk
Research field  (4): Medical pharmacy ,  Biological pharmacy ,  Drug development chemistry ,  Applied pharmacology
Research keywords  (2): Clinical Pharmacokinetics ,  Biopharmaceutics drug disposition transporter
Research theme for competitive and other funds  (1):
  • Drug transport across the blood brain barrier and blood CSF barrier
Papers (212):
  • Yoshikado T, Toshimoto K, Maeda K, Kusuhara H, Kimoto E, Rodrigues AD, Chiba K, Sugiyama Y. PBPK Modeling of Coproporphyrin I as an Endogenous Biomarker for Drug Interactions Involving Inhibition of Hepatic OATP1B1 and OATP1B3. CPT: pharmacometrics & systems pharmacology. 2018. 7. 11. 739-747
  • Murata H, Ito S, Kusuhara H, Nomura Y, Taniguchi T. Proposal of a Parameter for OATP1B1 Inhibition Screening at the Early Drug Discovery Stage. Journal of pharmaceutical sciences. 2019. 108. 12. 3898-3902
  • Yoshida K, Maeda K, Konagaya A, Kusuhara H. Accurate estimation of in vivo inhibition constants of inhibitors and fraction metabolized of substrates with physiologically-based pharmacokinetic drug-drug interaction models incorporating parent drugs and metabolites of substrates with cluster Newton m. Drug metabolism and disposition: the biological fate of chemicals. 2018. 46. 11. 1805-1816
  • Lee N, Maeda K, Fukizawa S, Ieiri I, Tomaru A, Akao H, Takeda K, Iwadare M, Niwa O, Masauji T, Yamane N, Kajinami K, Kusuhara H, Sugiyama Y. Microdosing clinical study to clarify pharmacokinetic and pharmacogenetic characteristics of atorvastatin in Japanese hypercholesterolemic patients. Drug metabolism and pharmacokinetics. 2019. 34. 6. 387-395
  • Asaumi R, Menzel K, Lee W, Nunoya KI, Imawaka H, Kusuhara H, Sugiyama Y. Expanded Physiologically-Based Pharmacokinetic Model of Rifampicin for Predicting Interactions With Drugs and an Endogenous Biomarker via Complex Mechanisms Including Organic Anion Transporting Polypeptide 1B Induction. CPT: pharmacometrics & systems pharmacology. 2019. 8. 11. 845-857
MISC (7):
Lectures and oral presentations  (51):
  • The Cell surface-resident ATP-binding Cassette Transporter A1 (ABCA1) is Ubiquitinated and Sorted to Lysosome for Degradation
    (81st EAS 2013)
  • ATP-binding Cassette Transporter A1 (ABCA1) Is Degraded In Lysosome Via Ubiquitination And ESCRT Machinery.
    (82nd EAS 2014)
  • Investigation of Transporters Responsible for the Renal Uptake and Efflux of Trimethylamine N-oxide
    (日本薬物動態学会 第30回年会 2015)
  • Organic Cation Transporter (OCT) is Responsible for the Renal Influx of Trimethylamine N-oxide
    (第21回創剤フォーラム若手研究会 2015)
  • Organic Cation Transporter (OCT) is Responsible for the Kinetics of Trimethylamine N-oxide (TMAO)
    (2015年度第3回 日本薬剤学会英語セミナー 2016)
Education (3):
  • 1991 - 1993 University of Tokyo
  • 1993 - 1995 University of Tokyo Faculty of Pharmaceutical Sciences
  • 1995 - 1997 University of Tokyo Graduate School of Pharmaceutical Sciences
Professional career (1):
  • PhD (The University of Tokyo)
Work history (5):
  • 1998/01 - 2003/12 The University of Tokyo Assistant Professor
  • 2004/01 - 2005/03 The University of Tokyo Associate Professor
  • 2005/04 - 2007/03 The University of Tokyo Associate Professor
  • 2007/04 - 2012/04 The University of tokyo Associate Professor
  • 2012/05 - 現在 The University of Tokyo Professor
Awards (2):
  • 2018 - Japan Research Foundation for Clinical Pharmacology Japan Research Foundation for Clinical Pharmacology Award
  • 2012 - Japan Research Foundation for Clinical Pharmacology Japan Research Foundation for Clinical Pharmacology Award
Association Membership(s) (7):
JAPANESE SOCIETY FOR ALTERNATIVES TO ANIMAL EXPERIMENTS ,  THE JAPANESE PHARMACOLOGICAL SOCIETY ,  American Society for Clinical Pharmacology and Therapeutics ,  The American Society for Pharmacology and Experimental Therapeutics ,  International Society for the Study of Xenobiotics ,  THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM ,  THE JAPANESE SOCIETY OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
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