Rchr
J-GLOBAL ID：200901065308217097
Update date: Jun. 14, 2024
Kakimi Kazuhiro
カキミカズ ヒロ | Kakimi Kazuhiro
Affiliation and department：
Job title：
Professor
Other affiliations (1)：
Homepage URL (2)：
https://immunotherapy-uth.jp/
,
https://immunotherapy-uth.jp/english/
Research field (1)：
Immunology
Research keywords (4)：
免疫細胞治療
, 癌免疫
, immuntoherapy
, cancer immunology
Research theme for competitive and other funds (56)：
- 2023 - 2026 胃がん腹膜播種の免疫細胞ネットワーク解明に基づく複合的がん免疫治療法の開発
- 2023 - 2026 Comprehensive analysis of the differentiation and function of neoantigen-specific T cells
- 2022 - 2024 見るだけでがんを攻撃するキラーT細胞を判別する顕微鏡・セルソーターの開発
- 2021 - 2024 A New Photodynamic Therapy System for Deep Organ Cancer Using an Implantable Light-Emitting Device
- 2021 - 2024 Development of new cancer therapy using IRE combined with checkpoint blockade
- 2021 - 2024 Tailor-made immunotherapy strategy for urothelial cancer using immunogram
- 2020 - 2023 Cancer immunotherapy by in vivo generation of CAR T cells based on targeted mRNA delivery
- 2020 - 2023 免疫チェックポイント阻害剤抵抗性肺がんに対するネオアンチゲンワクチン治療の開発
- 2019 - 2022 Regulation of anti-tumor immune response by cell-surface engineering and development of innovative proliferation method of tumor infiltrating T cells
- 2019 - 2022 Specific immune responses against tumor antigens in long term survivors of cancer
- 2019 - 2022 Attempt of segmentation of positive / negative factor and absolute evaluation of intra-tumor immunity
- 2019 - 2022 卵巣癌の個別化治療を目指した免疫プロファイルに基づく包括的バイオマーカーの開発
- 2020 - 2021 子宮体がん患者におけるマイクロサテライトフレームシフト変異に対する免疫応答の解析
- 2018 - 2021 Elucidation of a mechanism of abscopal effect -Innovative cancer treatment strategy-
- 2019 - 2020 Analysis of spatiotemporal heterogeneity in metastatic lung tumors
- 2017 - 2020 Development of a Lung Regenaration Model Using Autologous Cells
- 2017 - 2020 A role of immuno checkpoints for an immunodeficiency of patient with chronic kidney disease
- 2017 - 2020 Analysis of intratumoral immune response in gastric and esophageal cancer for optimal combination immunotherapy
- 2017 - 2020 Comprehensive profiling of tumor immune microenvironment for effective personalized lung cancer vaccine
- 2017 - 2020 Analysis of intratumoral immune response in head and neck cancer for optimal combination immunotherapy
- 2016 - 2019 Development of companion diagnostics for personalized cancer immunotherapy using denatured protein solubilization technology
- 2016 - 2019 Novel cancer immunotherapy targeting neoantigens in combination with epigenetics and immune modulation
- 2016 - 2019 Development of cancer immunotherapy targeting mutation-derived neoantigens
- 2015 - 2019 Analysis of intra-tumor immune response toward development of autologous gamma-delta T-cell transfer therapy in patients with advanced urothelial carcinoma
- 2015 - 2018 Development of personalized lung cancer vaccine targeting neoantigens
- 2015 - 2017 Detection of neoantigens by gene-engineered T cells
- 2014 - 2017 Mechanisms of histone-induced lung reperfusion injury after lung transplantation
- 2014 - 2017 Identification of neoantigens and development of a novel personalized lung cancer treatment targeting passenger mutations
- 2013 - 2016 Identification of unique antigens by next generation sequencing and development of individualized cancer immunotherapy in clear cell renal cell carcinoma
- 2013 - 2016 Mutanome analyses by next generation sequencing and individualized cancer vaccine development in gastric cancer
- 2013 - 2016 DC-based vaccination combined with interferon for metastatic renal cell carcinoma
- 2012 - 2016 Chimeric antigen receptor gamma delta T cell immunotherapy for the treatment of malignant mesothelioma
- 2012 - 2015 Reverse Translational Research for Understanding immune response in the Tumor and Identification of Biomarkers
- 2012 - 2015 Development of cancer vaccine therapy targeting individual genetic mutations identified by next generation sequencing
- 2011 - 2014 Application of protein cationization techniques for cancer immunotherapy
- 2011 - 2013 Vaccination therapy combined with chemotherapy for recurrent pancreatic cancer patients
- 2010 - 2012 Use of long overlapping peptides for cancer vaccine and Treg control for potentiating immune response
- 2010 - 2012 Mechanism of anti-infectious property of heart-valve and vascular homograftmanipulation
- 2009 - 2011 Novel radiation therapy with regulation of immune response
- 2009 - 2011 Clinical study on adoptive immunotherapy with autologous gammadelta T-lymphocyte for patients with pulmonary metastasis from colorectal cancer.
- 2008 - 2010 The analysis of inflammatory cascade between antigen specific CTLs and liver injury using hepatitis model
- 2008 - 2010 Combination adjuvant therapy using chemotherapy and immunotherapy for pancreatic cancer: assessment of safety and efficacy.
- 2009 - 2009 肺癌特異的αβT細胞受容体遺伝子を導入したγδT細胞を用いた肺癌のCTL治療
- 2007 - 2008 Novel combined modality therapy with radiotherapy and immunotherapy for the treatment of cancer
- 2007 - 2008 Clinical research of a new immunotherapy for the lung cancer : Autologous gamma-delta T-cell adoptive immunotherapy
- 2007 - 2008 Mechanism of anti-infectious capacity of cryopreserved heart-valve and vascularallograft against Methicillin-resistant Staphylococcus aureus
- 2007 - 2008 生体の腫瘍免疫応答を利用した新たな放射線治療法の開発
- 2006 - 2008 Analysis of generation and control mechanism of CD8+ T cells by chemokines
- 2007 - 2007 デンドリマー型光増感剤を用いた抗原導入法による樹状細胞ワクチン開発
- 2006 - 2007 肝細胞癌ラジオ波熱焼灼療法(RFA)後の再発予防を目指した樹状細胞の腫瘍内投与
- 2005 - 2006 Immunoregulatory mechanisms for the hepatitis virus specific T cell response
- 2005 - 2006 Clinical research on a new immunotherapy for the treatment of non-small cell lung cancer
- 2005 - 2006 Establishment of database of IFN-α production test and risk management of hepatocellular carcinoma in patients with hepatitis C virus.
- 2004 - 2006 Holocular Targeted Therapy in hemabrogical neoplasm: Telomerase Inhibition
- 2005 - 2005 肝細胞癌ラジオ波熱焼灼療法後の樹状細胞局所治療?肝がん再発予防DCワクチン?
- 2003 - 2004 Pathogenesis of viral hepatitis based on intrahepatic immune response to hepatitis virus
Show all
Papers (136)：
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Wan-Ying Du, Hiroki Masuda, Koji Nagaoka, Tomohiko Yasuda, Komei Kuge, Yasuyuki Seto, Kazuhiro Kakimi, Sachiyo Nomura. Janus kinase inhibitor overcomes resistance to immune checkpoint inhibitor treatment in peritoneal dissemination of gastric cancer in C57BL/6 J mice. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association. 2024
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Yoshihiro Kushihara, Shota Tanaka, Yukari Kobayashi, Koji Nagaoka, Miyu Kikuchi, Takahide Nejo, Erika Yamazawa, Shohei Nambu, Kazuha Kugasawa, Hirokazu Takami, et al. Glioblastoma with high O6-methyl-guanine DNA methyltransferase expression are more immunologically active than tumors with low MGMT expression. Frontiers in immunology. 2024. 15. 1328375-1328375
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Yuki Okawa, Shota Sasagawa, Hiroaki Kato, Todd A Johnson, Koji Nagaoka, Yukari Kobayashi, Akimasa Hayashi, Takahiro Shibayama, Kazuhiro Maejima, Hiroko Tanaka, et al. Immuno-genomic analysis reveals eosinophilic feature and favorable prognosis of female non-smoking esophageal squamous cell carcinomas. Cancer letters. 2023. 581. 216499-216499
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Yasuyoshi Sato, Hiroharu Yamashita, Yukari Kobayashi, Koji Nagaoka, Tetsuro Hisayoshi, Takuya Kawahara, Akihiro Kuroda, Noriyuki Saito, Ryohei Iwata, Yasuhiro Okumura, et al. Alterations in Intratumoral Immune Response before and during Early-On Nivolumab Treatment for Unresectable Advanced or Recurrent Gastric Cancer. International journal of molecular sciences. 2023. 24. 23
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菊池 美佑, 小林 由香利, 長岡 孝治, 垣見 和宏. 【免疫チェックポイント阻害剤の副作用-irAEの発生メカニズムとその対処方法】免疫チェックポイント阻害剤によるirAE発生のメカニズム. カレントテラピー. 2023. 41. 7. 592-597
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MISC (288)：
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黒田 晃弘, 小林 由香利, 長岡 孝治, 垣見 和宏. 【外科医が知っておくべき! 免疫チェックポイント阻害薬】総論 外科医にとっての免疫チェックポイント阻害薬. 臨床外科. 2023. 78. 1. 6-11
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宮本 愛, 本莊 知子, 益井 実鈴, 木下 理恵, 公文 裕巳, 垣見 和宏, 二見 淳一郎. がん免疫サイクルのレベルを末梢血で評価する自己抗体バイオマーカー群網羅的測定法の確立. 日本生物工学会大会講演要旨集. 2022. 2022年. 223-223
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孫 長博, 長岡 孝治, 小林 由香利, 垣見 和宏, 中島 淳. Neoantigen vaccination provides therapeutic benefit of anti-PD-1 by increasing neoantigen-specific CD8+T cells(タイトル和訳中). 日本胸部外科学会定期学術集会. 2022. 75回. LP2-5
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長岡 孝治, 小林 由香利, 孫 長博, 加藤 洋人, 石川 俊平, 中川 英刀, 垣見 和宏. MHCテトラマーの検出を逃れたネオアンチゲン特異的ステルスCD8+T細胞のscTCR-Seqによる捕捉(scTCR-Seq captured stealth neoantigen-specific CD8+ T cells that escaped from the MHC tetramer staining in the tumor.). 日本癌学会総会記事. 2022. 81回. IS2-2
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垣見 和宏. がん免疫と免疫治療の最近の進歩(Recent Advances in Cancer Immunology and Immunotherapy). 日本癌学会総会記事. 2022. 81回. IC3-1
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Patents (13)：
Books (2)：
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必修!腫瘍免疫学
金原出版 2022 ISBN:9784307102087
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がん免疫ペディア : 腫瘍免疫学・がん免疫療法の全てをまるごと理解!
羊土社 2022 ISBN:9784758121194
Professional career (1)：
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