Kakimi Kazuhiro

2023 - 2026 胃がん腹膜播種の免疫細胞ネットワーク解明に基づく複合的がん免疫治療法の開発

2023 - 2026 Comprehensive analysis of the differentiation and function of neoantigen-specific T cells

2022 - 2024 見るだけでがんを攻撃するキラーT細胞を判別する顕微鏡・セルソーターの開発

2021 - 2024 A New Photodynamic Therapy System for Deep Organ Cancer Using an Implantable Light-Emitting Device

2021 - 2024 Development of new cancer therapy using IRE combined with checkpoint blockade

2021 - 2024 Tailor-made immunotherapy strategy for urothelial cancer using immunogram

2020 - 2023 Cancer immunotherapy by in vivo generation of CAR T cells based on targeted mRNA delivery

2020 - 2023 免疫チェックポイント阻害剤抵抗性肺がんに対するネオアンチゲンワクチン治療の開発

2019 - 2022 Regulation of anti-tumor immune response by cell-surface engineering and development of innovative proliferation method of tumor infiltrating T cells

2019 - 2022 Specific immune responses against tumor antigens in long term survivors of cancer

2019 - 2022 Attempt of segmentation of positive / negative factor and absolute evaluation of intra-tumor immunity

2019 - 2022 卵巣癌の個別化治療を目指した免疫プロファイルに基づく包括的バイオマーカーの開発

2020 - 2021 子宮体がん患者におけるマイクロサテライトフレームシフト変異に対する免疫応答の解析

2018 - 2021 Elucidation of a mechanism of abscopal effect -Innovative cancer treatment strategy-

2019 - 2020 Analysis of spatiotemporal heterogeneity in metastatic lung tumors

2017 - 2020 Development of a Lung Regenaration Model Using Autologous Cells

2017 - 2020 A role of immuno checkpoints for an immunodeficiency of patient with chronic kidney disease

2017 - 2020 Analysis of intratumoral immune response in gastric and esophageal cancer for optimal combination immunotherapy

2017 - 2020 Comprehensive profiling of tumor immune microenvironment for effective personalized lung cancer vaccine

2017 - 2020 Analysis of intratumoral immune response in head and neck cancer for optimal combination immunotherapy

2016 - 2019 Development of companion diagnostics for personalized cancer immunotherapy using denatured protein solubilization technology

2016 - 2019 Novel cancer immunotherapy targeting neoantigens in combination with epigenetics and immune modulation

2016 - 2019 Development of cancer immunotherapy targeting mutation-derived neoantigens

2015 - 2019 Analysis of intra-tumor immune response toward development of autologous gamma-delta T-cell transfer therapy in patients with advanced urothelial carcinoma

2015 - 2018 Development of personalized lung cancer vaccine targeting neoantigens

2015 - 2017 Detection of neoantigens by gene-engineered T cells

2014 - 2017 Mechanisms of histone-induced lung reperfusion injury after lung transplantation

2014 - 2017 Identification of neoantigens and development of a novel personalized lung cancer treatment targeting passenger mutations

2013 - 2016 Identification of unique antigens by next generation sequencing and development of individualized cancer immunotherapy in clear cell renal cell carcinoma

2013 - 2016 Mutanome analyses by next generation sequencing and individualized cancer vaccine development in gastric cancer

2013 - 2016 DC-based vaccination combined with interferon for metastatic renal cell carcinoma

2012 - 2016 Chimeric antigen receptor gamma delta T cell immunotherapy for the treatment of malignant mesothelioma

2012 - 2015 Reverse Translational Research for Understanding immune response in the Tumor and Identification of Biomarkers

2012 - 2015 Development of cancer vaccine therapy targeting individual genetic mutations identified by next generation sequencing

2011 - 2014 Application of protein cationization techniques for cancer immunotherapy

2011 - 2013 Vaccination therapy combined with chemotherapy for recurrent pancreatic cancer patients

2010 - 2012 Use of long overlapping peptides for cancer vaccine and Treg control for potentiating immune response

2010 - 2012 Mechanism of anti-infectious property of heart-valve and vascular homograftmanipulation

2009 - 2011 Novel radiation therapy with regulation of immune response

2009 - 2011 Clinical study on adoptive immunotherapy with autologous gammadelta T-lymphocyte for patients with pulmonary metastasis from colorectal cancer.

2008 - 2010 The analysis of inflammatory cascade between antigen specific CTLs and liver injury using hepatitis model

2008 - 2010 Combination adjuvant therapy using chemotherapy and immunotherapy for pancreatic cancer: assessment of safety and efficacy.

2009 - 2009 肺癌特異的αβT細胞受容体遺伝子を導入したγδT細胞を用いた肺癌のCTL治療

2007 - 2008 Novel combined modality therapy with radiotherapy and immunotherapy for the treatment of cancer

2007 - 2008 Clinical research of a new immunotherapy for the lung cancer : Autologous gamma-delta T-cell adoptive immunotherapy

2007 - 2008 Mechanism of anti-infectious capacity of cryopreserved heart-valve and vascularallograft against Methicillin-resistant Staphylococcus aureus

2007 - 2008 生体の腫瘍免疫応答を利用した新たな放射線治療法の開発

2006 - 2008 Analysis of generation and control mechanism of CD8+ T cells by chemokines

2007 - 2007 デンドリマー型光増感剤を用いた抗原導入法による樹状細胞ワクチン開発

2006 - 2007 肝細胞癌ラジオ波熱焼灼療法(RFA)後の再発予防を目指した樹状細胞の腫瘍内投与

2005 - 2006 Immunoregulatory mechanisms for the hepatitis virus specific T cell response

2005 - 2006 Clinical research on a new immunotherapy for the treatment of non-small cell lung cancer

2005 - 2006 Establishment of database of IFN-α production test and risk management of hepatocellular carcinoma in patients with hepatitis C virus.

2004 - 2006 Holocular Targeted Therapy in hemabrogical neoplasm: Telomerase Inhibition

2005 - 2005 肝細胞癌ラジオ波熱焼灼療法後の樹状細胞局所治療?肝がん再発予防DCワクチン?

2003 - 2004 Pathogenesis of viral hepatitis based on intrahepatic immune response to hepatitis virus