Rchr

J-GLOBAL ID：200901065424752846 Update date: Oct. 06, 2024

Shimizu Akira

シミズアキラ | Shimizu Akira

Affiliation and department：
Other affiliations (1)：

Nippon Medical School

Research field (2)： Experimental pathology , Human pathology

Research keywords (6)：移植病理 , 腎臓病理 , 実験糸球体腎炎 , pathology of the transplantation , pathology of the kidney , experimental renal disease

Research theme for competitive and other funds (44)：

2023 - 2026 Exploration of biomarker in preclinical experiments for optimal monitoring of mTOR inhibitors after kidney transplantation
2023 - 2026 Identification of disease-specific proteins in glomerular diseases and renal deposition diseases by mass spectrometry using renal biopsy specimens
2021 - 2025 国際研究ネットワークの構築に基づく異種移植実用化戦略の確立
2021 - 2024 フロント阻害薬ジスルフィラムによるマクロファージ阻害を介した糖尿病腎線維化の抑制
2021 - 2024 ネフロン数と単一ネフロンパラメータの臨床応用

2020 - 2023 内皮細胞のheterogeneityに着目した糸球体毛細血管網の維持機構の解明

2019 - 2023 自然・獲得免疫系を繋ぐ肺胞マクロファージの機序解明による同種・異種肺移植成績向上

2020 - 2023 The identification of the antigen and deposition proteins in glomerulonephritis and glomerular deposition diseases

2019 - 2022 Integrated omics analysis for drug discovery of intractable nephrotic syndrome

2019 - 2020 前臨床モデルでの移植片対宿主反応(LGVHR)に基づく革新的小腸移植免疫寛容誘導

2017 - 2020 Injuries of glomerular basement membrane in the progression of glomerular diseases

2016 - 2019 Effects of long-term hypergastrinemia on gastric mucosa

2016 - 2019 Modulation of inflammation and innate immune responses subsequent to endothelial cell damage in lung allo and xenotransplantation

2016 - 2019 Establish a treatment strategy to diabetic nephropathy using combined kidney and islets transplantation

2015 - 2018 Establishment of hydrogen sulfide therapy against renal ischemia-reperfusion injury using large animal to attempt to increase the donor organ pool

2015 - 2017 Basic research on technology development of tooth regeneration with regard to transcription factor Cebpb and Runx2

2014 - 2017 The pathological and immunological characteristics of grafts with long-term acceptance in rat liver transplantation

2014 - 2016 Establishment of novel lung preservation method in a stable unfrozen state under high pressurized condition

2013 - 2016 Effects of carbon monoxide inhalation on allograft survival of the lung or kidney from brain death donors in miniature swine.

2013 - 2016 Establishment of polychromatic FACS analysis for diagnosis of glomeluronephritis instead of pathology

2012 - 2015 Immunological network in ANCA associated glomerulonephritis

2011 - 2014 Attenuation of hyperacute dysfunction and coagulopathy in GalT-KO pulmonary xenotransplantation

2011 - 2014 Intestinal Transplantation in CLAWN Miniature Swine: Establishment of Orthotopic Model and Roles of Chimerisms, HVG and GVH Responses

2011 - 2013 Inflammation in rat liver transplantation model

2010 - 2012 Role of prevascularization of islets in the induction of tolerance of allogeneic islets in miniature swine

2010 - 2012 Attempt to induce tolerance of kidneys by pharmacologic rejuvenation of thymus in miniature swine

2008 - 2010 Xenotransplantation from GalT-KO miniture swine to baboon in tolerance induction protocol

2007 - 2010 GalT-knockout pig to monkey xenogeneic kidney and islet transplantation

2007 - 2008 Effect of HGF on chronic changes in renal allografts in partial ly inbred miniature swine

2006 - 2007 The mechanisms of graft failure in cardiac xenografts from α1,3-galactosyltransferase, gene-knockout (GalT-KO) pigs in babooons

1999 - 2002 同種腎移植における免疫寛容(トレランス)導入と移植臓器における免疫応答の特異性

1994 - 1995 増殖性糸球体腎炎の回復過程におけるアポトーシスの役割について

臓器移植後慢性拒絶反応の進展機序

糸球体腎炎における血管傷害,再生,新生

糸球体腎炎の進展機序

糸球体腎炎の進展の制御に関する研究

糸球体腎炎の進展機序に関する研究

血管傷害,血管新生・再生と糸球体腎炎に関する研究

the mechanisms of the progression of chronic rejection

vascular injury and angiogenesis in glomerulonephritis

the mechanisms of the progressine glomerulonephritis

Study on the treatment of progressine glomerulonephritis

Study on the mechanism of progressine glomerulonephritis

Study on vascular injury and angiogenesis in glomerulonephritis

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Papers (400)：

上條夏実, 三井亜希子, 中里玲, 酒井行直, 柏木哲也, 大橋隆治, 清水章, 岩部真人. ANCA関連血管炎の疾患活動性とシトルリン化ヒストン陽性好中球の関連. 日本腎臓学会誌. 2024. 66. 4. 640-640
Hitoshi Goto, Takeshi Arima, Akira Takahashi, Yutaro Tobita, Yuji Nakano, Etsuko Toda, Akira Shimizu, Fumiki Okamoto. Trimebutine prevents corneal inflammation in a rat alkali burn model. Scientific reports. 2024. 14. 1. 12111-12111
山下真由, 酒井行直, 荒谷紗絵, 田邊博人, 宮本大資, 平間章郎, 大橋隆治, 清水章, 柏木哲也, 岩部真人. 混合性結合組織病に発症したネフローゼ症候群緊急透析から完全寛解・透析離脱に至った1例. 日本透析医学会雑誌. 2024. 57. Suppl.1. 459-459
Weili Chen, Etsuko Toda, Kazuhiro Takeuchi, Yurika Sawa, Kyoko Wakamatsu, Naomi Kuwahara, Arimi Ishikawa, Yuri Igarashi, Mika Terasaki, Shinobu Kunugi, et al. Disulfiram treatment suppresses antibody-producing reactions by inhibiting macrophage activation and B cell pyrimidine metabolism. Communications Biology. 2024
Kenta Tominaga, Etsuko Toda, Kazuhiro Takeuchi, Shoichiro Takakuma, Emi Sakamoto, Hideaki Kuno, Yusuke Kajimoto, Yasuhiro Terasaki, Shinobu Kunugi, Akiko Mii, et al. Predominant CD8+ cell infiltration and low accumulation of regulatory T cells in immune checkpoint inhibitor-induced tubulointerstitial nephritis. Pathology international. 2024

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MISC (719)：

平形希利慧, 高橋慶, 高橋慶, 飛田悠太朗, 中野優治, 有馬武志, 遠田悦子, 清水章, 高橋浩. A novel method of multiple analyses for a single cornea specimen. 日本角膜学会総会・日本角膜移植学会プログラム・抄録集. 2023. 47th-39th
川原稔己, 高橋慶, 高橋慶, 飛田悠太朗, 中野優治, 有馬武志, 遠田悦子, 清水章, 高橋浩. Effects of the anterior ocular inflammation on the Zinn’s zonule. 日本角膜学会総会・日本角膜移植学会プログラム・抄録集. 2023. 47th-39th
宮内翔吾, 木村剛, 武田隼人, 遠藤勇気, 赤塚純, 三神晃, 戸山友香, 大林康太郎, 長谷川裕也, 柴崎幹生, et al. 原発巣不明転移性胚細胞腫瘍治療21年後に異時性精巣腫瘍を認めた1例. 日本泌尿器科学会東部総会プログラム・抄録集. 2023. 88th (CD-ROM)
康徳東, 余曉洋, 高木孝士, 竹内和博, 澤智華, 清水章, 本田一穂. ラット腎臓の発生におけるネフロンの3次元再構築. 日本解剖学会総会・全国学術集会抄録集(CD-ROM). 2023. 128th
平野景太, 川村哲也, 小池健太郎, 西川正子, 清水章, 城謙輔, 片渕律子, 橋口明典, 松崎慶一, 丸山彰一, et al. IgA腎症におけるステロイド療法,扁摘と腎予後の関連性. 日本腎臓学会誌(Web). 2023. 65. 3

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Works (4)：

腎臓移植における免疫寛容
1999 -
腎臓移植における慢性拒絶反応
1999 -
Tolerance in renal transplantation
1999 -
The chronic rejection in renal transplantation
1999 -

Education (4)：

- 1993 Nippon Medical School
- 1993 Nippon Medical School Graduate School, Division of Medicine
- 1985 Kanazawa Medical University School of Medicine
- 1985 Kanazawa Medical University Faculty of Medicine

Professional career (1)：

(BLANK) (Nippon Medical School)

Work history (28)：

2013/06 - 現在 Nippon Medical School Faculty of Medicine, Department of Pathology 准教授
2017/04 - 2020/03 Nippon Medical School
2006 - 2013/05 - 日本医科大学解析人体病理学 (旧病理学第一) 准教授
2005 - 2006 年日本医科大学病理学第一助教授
2003 - 2005 Instructor, Transplantation Biology Research Center (Dr. David H.Sachs), Massachusetts General Hospital/Harvard Medical School

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Awards (3)：

2019/02 - 日本腎臓財団学術賞
2006 - 日本病理学会学術研究賞
1995 - 日本医科大学同窓会賞

Association Membership(s) (5)：

THE JAPANESE SOCIETY OF PATHOLOGY , JAPANESE SOCIETY OF NEPHROLOGY , 日本腎病理協会 , 移植腎病理研究会 , 日本臨床腎移植学会

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