Rchr
J-GLOBAL ID：200901065437536590
Update date: Apr. 18, 2024
Oikawa Hideaki
オイカワ ヒデアキ | Oikawa Hideaki
Affiliation and department：
Homepage URL (1)：
http://wwwchem.sci.hokudai.ac.jp/~yuhan/
Research field (1)：
Bioorganic chemistry
Research keywords (3)：
天然物化学
, 生物有機化学
, Natural Products Chemistry and Bioorganic Chemistry
Research theme for competitive and other funds (25)：
- 2019 - 2022 Exploring new biologically active metabolites using unidentified gene clusters from Basidiomycota genomes
- 2015 - 2018 Development of versatile synthesis for fungal natural products by reconstitution of biosynthetic machinery
- 2015 - 2017 Construction of convergent library for fungal cytochrome P450s and its application to exploring novel functions
- 2010 - 2015 Biosynthetic machinery: Deciphering and regulating the system for bioactive metabolite diversification
- 2013 - 2014 Development of a rational protocol searching novel biosynthetic gene clusters for natural product synthesis
- 2010 - 2014 Biosynthetic machinery: Deciphering and regulating the system for creating structural diversity of baioactive metabolites
- 2010 - 2014 Reconstitution of anticancer agent-biosynthetic machinery and elucidation of its mechanism on molecular diversification
- 2010 - 2011 Phosphodiesterase特異的阻害剤longestinの酵素的全合成
- 2008 - 2010 Functional analysis of modular enzymes and its application to the synthesis of antitumor agents
- 2006 - 2007 ポリペプチド合成酵素を用いた抗がん剤ライブラリーの構築
- 2005 - 2007 Studies on the Mechanism of Constructing Molecular Skeletons of Bioactive Polyether Metabolites
- 2004 - 2006 Studies on production and improvement of terpenoids using biosynthetic gene cluster in fungi and plants.
- 2002 - 2004 Study on cloning of diterpene synthase genes from plants
- 2001 - 2003 Scientific research on elucidation of terpene-cyclic reactions in the biosynthesis of bioactive microbial terpenoids.
- 1999 - 2001 Study of the role of phototoxins in toxin-induced symptom development
- 1998 - 2000 Large-scale Production of Antivirus Agent Based on Engineered Biosynthesis
- 1997 - 1998 Study on Inhibition Mechanism and Rational Design of Protein Phosphatase Inhibitor Tautomycin
- 1994 - 1996 Chemistry and New Development of Phytotoxin
- 1993 - 1994 生合成における酵素的Diels-Alder反応-----その証明と反応機構
- 1990 - 1990 トマト宿主特異的毒素AAL-toxinの合成による絶対配置の決定
- 1988 - 1989 Symptom and sign of infected plants--chemistry and biological activity-
- 1988 - 1988 チトクロームP-450阻害剤を用いた天然生理活性物質の生合成研究
- ポリエーテル系抗生物質生合成遺伝子のクローニング
- 酵素を活用した非天然型生理活性有機分子群の合成法開拓と機能解析
- ポリペプチド合成酵素を利用した有機合成
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Papers (152)：
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Yoshiro Sato, Xinge Shi, Ying Ye, Saori Domon, Junya Takino, Taro Ozaki, Chengwei Liu, Hideaki Oikawa, Atsushi Minami. Bioinformatics-Guided Reconstitution of Biosynthetic Machineries of Fungal Eremophilane Sesquiterpenes. ACS chemical biology. 2024
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Kei Hiruma, Seishiro Aoki, Junya Takino, Takeshi Higa, Yuniar Devi Utami, Akito Shiina, Masanori Okamoto, Masami Nakamura, Nanami Kawamura, Yoshihiro Ohmori, et al. A fungal sesquiterpene biosynthesis gene cluster critical for mutualist-pathogen transition in Colletotrichum tofieldiae. Nature communications. 2023. 14. 1. 5288-5288
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Mitsunori Fukaya, Shota Nagamine, Taro Ozaki, Yaping Liu, Miina Ozeki, Taro Matsuyama, Kazunori Miyamoto, Hirokazu Kawagishi, Masanobu Uchiyama, Hideaki Oikawa, et al. Total Biosynthesis of Melleolides from Basidiomycota Fungi: Mechanistic Analysis of the Multi-Functional GMC Oxidase Mld7. Angewandte Chemie (International ed. in English). 2023. e202308881
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Yaping Liu, Taro Ozaki, Atsushi Minami, Hideaki Oikawa. Oxidative bicyclic ring system formation involving indole diterpene biosynthesis: Remarkable substrate tolerance of a prenyltransferase and flavoprotein oxidase. Tetrahedron Letters. 2023
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Taro Ozaki, Atsushi Minami, Hideaki Oikawa. Recent advances in the biosynthesis of ribosomally synthesized and posttranslationally modified peptides of fungal origin. The Journal of antibiotics. 2022
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MISC (265)：
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深谷充功, 尾関美衣菜, 尾崎太郎, 永木愛一郎, 南篤志, 及川英秋. Total biosynthesis of the basidiomycete derived antitumor substance melleolide (2). 日本化学会春季年会講演予稿集(Web). 2023. 103rd
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瀧野純矢, 山本真太郎, 尾崎太郎, 永木愛一郎, 南篤志, 及川英秋. Mechanistic Studies on the Late-Stage Modification Enzymes in the Biosynthesis of Phomoidride B. 日本化学会春季年会講演予稿集(Web). 2023. 103rd
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小林瑞季, 尾崎太郎, 橋本勝, 永木愛一郎, 南篤志, 及川英秋. Exploration and functional analysis of sesquiterpene biosynthetic genes based on comprehensive analysis of terpene synthase. 日本化学会春季年会講演予稿集(Web). 2023. 103rd
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瀧野純矢, 山本真太郎, 尾崎太郎, 永木愛一郎, 南篤志, 及川英秋, 及川英秋. Total Biosynthesis of Phomoidride B: Identification and Characterization of Methyltransferase Catalyzing Bicyclic Ketal Formation. 日本農芸化学会大会講演要旨集(Web). 2023. 2023
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瀧野純矢, 小谷明里, 尾崎太郎, YU Jie, GUO Yian, YE Tao, 南篤志, 及川英秋. Stereochemical analysis of highly reducing polyketide syntheses. 日本化学会春季年会講演予稿集(Web). 2022. 102nd
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Patents (1)：
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アフィディコリン生合成酵素遺伝子クラスター:科学技術振興事業団
Books (9)：
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有用生物活性ポリエーテル化合物の骨格構築機構の解明
[北海道大学大学院理学研究院] 2008
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植物ジテルペン環化酵素遺伝子取得法の確立
[北海道大学大学院理学研究科] 2005
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植物病原菌感染過程における植物毒素の果たす機能の経時的解析法の確立
[北海道大学大学院農学研究科] 2002
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生合成工学に基づく組み換え微生物による抗ウイルス剤の大量生産
[北海道大学大学院農学研究科] 2001
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蛋白脱リン酸化酵素阻害剤トートマイシンの阻害機構の解明と論理的再構築
[及川英秋] 1999
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Education (4)：
- - 1984 Hokkaido University
- - 1984 Hokkaido University Graduate School, Division of Agriculture
- - 1979 Hokkaido University Faculty of Agriculture
- - 1979 Hokkaido University Faculty of Agriculture
Professional career (1)：
Work history (5)：
- 2003/04 - 現在 北海道大学大学院理学研究科 化学専攻 教授
- 1999/04 - 2003/03 北海道大学大学院農学研究科 応用生命科学専攻 助教授
- 1986/04 - 1999/03 Hokkaido University Faculty of Agriculture
- 1985/10 - 1986/03 理化学研究所抗生物質研究室 博士研究員
- 1984/04 - 1985/09 米国ブラウン大学化学科 博士研究員
Awards (4)：
- 2019/03 - The Japan Society for Bioscience, Biotechnology, and Agrochemistry JSBBA Award
- 2017/04 - 文部科学省 文部科学大臣表彰科学技術賞 設計図を活用した麹菌異種発現法による有用天然物の生産研究
- 2004 - 日本化学会学術賞
- 1993 - 農芸化学奨励賞
Association Membership(s) (3)：
日本化学会
, アメリカ化学会
, 日本農芸化学会
