Iwabuchi Yoshiharu

イワブチヨシハル | Iwabuchi Yoshiharu

Affiliation and department：
Job title： Professor
Homepage URL (2)： http://www.pharm.tohoku.ac.jp/~gousei/synthetic/index.html , http://db.tohoku.ac.jp/whois/e_detail/e94e752dd7745d2dedcafd74c51ec0c4.html

Research field (2)： Pharmaceuticals - chemistry and drug development , Molecular biochemistry

Research keywords (3)： medicinal chemistry , bioorganic chemistry , synthetic organic chemistry

Research theme for competitive and other funds (30)：

2022 - 2025 有機ニトロキシルラジカルー遷移金属協奏触媒の機能創成を機軸とする精密有機分子構築
2021 - 2023 ゲノムワイドCRISPRスクリーニング法を用いた糖尿病性腎症の新規創薬・病態解明
2020 - 2023 糖質応答転写因子ChREBPを標的とした糖尿病性腎症の病態解明・新規創薬
2019 - 2022 Synthesis and structural diversification of induced pluripotent stem molecules based on polyene macrolactam natural products
2019 - 2022 Precise construction of organic molecules based on organonitroxyl radical-transition metal hybrid catalysts

2018 - 2020 Development of highly enantioseletive aerobic alcohol oxidation system based on chiral AZADO-Cu cooperative catalysis

2016 - 2019 Development of nitrogen-containing versatile chiral building blocks driven by novel chemoselctive catalysis

2016 - 2018 AZADO-Cu協奏触媒の高度機能化による高難度アルコール選択的空気酸化

2016 - 2018 Challenge toward controlling oxidative phenol coupling reaction by AZADO-Cu cooperative catalysis

2013 - 2016 Pharmacological potential of curcumin analog targeting KSRP, a regulator of miRNA

2011 - 2016 Eco-benign Synthesis of Versatile Chiral Building Blocks Driven by Organocatalysis

2013 - 2015 Development of prodrugs based on a controlled reversible Michael reactions

2012 - 2015 Development of aerobic alcohol oxidation systems based on nitroxyl radical-Cu catalysis

2011 - 2012 Novel Oxidative Synthetic Transformations Driven by Chiral Oxoammmonium Salts

2010 - 2012 Development of a new cancer chemotherapy by using curcumin analogs

2010 - 2012 Drug development targeting for regeneration of neurovascular units in neurodegenerative disorders

2009 - 2011 Development of oxoammonium-salt-type catalysts for highly enantioselective oxidation of alcohols

2008 - 2009 有機ニトロキシルラジカルをモチーフとする酸化ストレス防御活性薬剤の創製

2007 - 2009 Development of novel neuroprotective drugs targeting for neurovascular unit therapy.

2006 - 2007 新規グルタミン酸配座固定化分子の合成に基づく受容体機能探索子の創製

2005 - 2007 Exploitation of Nitroxyl Radidal-type Organocatalysts for Alcohol Oxidation and their Use in Fine Synthetic Chemistry

2005 - 2006 アダマンタンアミン類の精密構造修飾に基づく高特異的イオンチャネルブロック薬の創製

2005 - 2005 キラルアダマンタンアミン類の合成に基づくグルタミン酸受容体機能解明ツールの創製

2004 - 2005 Development of a nobel strategy for chemoprevention of colorectal carcinogenesis by using newly synthesized organic compounds derived from natural dietary constituents

2001 - 2002 Synthetic Studies on Substituted Citrate Natural Products based on the Cinchona Alkaloid-Catalyzed Asymmetric Baylis-Hillman reaction

2001 - 2002 Synthesis of structurally unique natural products having glutamate receptor agonist and antagonist activities

1999 - 2000 脳神経系の分子レベルでの機能解明を目指す精密有機合成化学的アプローチ

1999 - 1999 新規抗マラリア剤の開発を目指すフェブリフジン類アルカロイドの合成研究

1998 - 1999 触媒的不斉Baylis-Hillman反応の開発とその活用に関する研究

1995 - 1997 Exploitation of an Efficient and Practical Method for the Synthesis of Active Vitamin D_3 Derivatives

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Papers (229)：

Hiroyuki Yamakoshi, Michihiro Fukuda, Hiro Ikeda, Shogo Fujiki, Aki Kohyama, Shota Nagasawa, Hanae Shinozaki, Hiroyuki Shibata, Yoshiharu Iwabuchi. Design, Synthesis, and Biological Evaluation of Water-Soluble Prodrugs of C5-Curcuminoid GO-Y030 Based on Reversible Thia-Michael Reaction. Chemical and Pharmaceutical Bulletin. 2024. 72. 1. 127-134
Masaki Nishijima, Yusuke Sasano, Yoshiharu Iwabuchi, Yasuyuki Araki. Comprehensive Structural and Electronic Properties of 2-Azaadamantane N-Oxyl Derivatives Correlated with Their Catalytic Ability. ACS Omega. 2023. 8. 49067-49072
Tetsuya Ono, Fumiya Sato, Masayuki Kumano, Sachiko Komatsu, Kyoko Sugiyama, Kazuhiro Watanabe, Kentaro Yoshida, Yusuke Sasano, Tsutomu Fujimura, Yoshiharu Iwabuchi, et al. Determination of antibiotics by amperometry using nortropine N-oxyl, a highly active nitroxyl radical. Analytical Sciences. 2023
Takashi MaruYama, Hiroyuki Yamakoshi, Yoshiharu Iwabuchi, Hiroyuki Shibata. Mono-Carbonyl Curcumin Analogs for Cancer Therapy. Biological and Pharmaceutical Bulletin. 2023. 46. 6. 756-763
Yuki Tateishi, Ryo Sato, Shingo Komatsu, Masatsugu Noguchi, Shota Nagasawa, Yusuke Sasano, Naoki Kanoh, Yoshiharu Iwabuchi. Asymmetric Total Synthesis of Cytotrienin A: Late-stage Installation of C11 Side Chain onto the Macrolactam Scaffold. Angewandte Chemie (International ed. in English). 2023. e202303140

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MISC (182)：

吉木美穂, 吉木美穂, 三村匠太朗, 小林容直, 李智成, 小山栞, 岩渕好治, 横江弘雅, 横江弘雅, 叶直樹, et al. 三成分連結による3-エノイルテトラミンの酸誘導体の簡便合成法の開発(I). 日本薬学会関東支部大会講演要旨集. 2022. 66th (CD-ROM)
小林容直, 三村匠太朗, 吉木美穂, 吉木美穂, 李智成, 小山栞, 岩渕好治, 横江弘雅, 横江弘雅, 叶直樹, et al. 三成分連結による3-エノイルテトラミン酸誘導体の簡便合成法の開発(2). 日本薬学会関東支部大会講演要旨集. 2022. 66th (CD-ROM)
Shota Nagasawa, Yusuke Sasano, Yoshiharu Iwabuchi. THE UTILITY OF OXOAMMONIUM SPECIES IN ORGANIC SYNTHESIS: BEYOND ALCOHOL OXIDATION. Heterocycles. 2022. 105. 1. 61-114
Yoshiharu Iwabuchi. Directing carboxylic acid dehydrogenation. Science. 2021. 374. 6572. 1199-1199
叶直樹, 叶直樹, 寺嶋優太, 田中卓, 寺島隆世, 西山大陸, 長澤翔太, 笹野裕介, 岩渕好治. Studies directed toward the creation of induced pluripotent small (iPS) molecules based on naturally occurring polyene macrolactams. 複素環化学討論会講演要旨集. 2021. 50th

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Education (2)：

- 1991 Tohoku University Graduate School, Division of Pharmaceutical Sciences
- 1986 Tohoku University Faculty of Pharmaceutical Science 製薬化学科

Professional career (1)：

Ph.D. (Tohoku University)

Work history (7)：

2021/04 - 現在東北大学大学院薬学研究科研究科長
2002/07 - 現在 Tohoku University Graduate School of Pharmaceutical Sciences Professor
1997/04 - 2002/06 Nagasaki University Faculty of Pharmaceutical Sciences Associate Professor
1995/10 - 1997/03 Biomolecular Engineering Research Institute
1992/05 - 1995/06 Protein Engineering Research Institute

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Committee career (4)：

2023/04 - 現在日本薬学会会頭
2021/04 - 2023/03 日本薬学会副会頭
2020/03 - 2022/02 有機合成化学協会理事
2020/04 - 2021/03 日本薬学会化学系薬学部会部会長

Awards (3)：

2012/03 - 日本薬学会学術振興賞高活性アルコール酸化触媒AZADOの発見と展開
2006/12 - 日本プロセス化学会優秀賞高活性アルコール酸化触媒1-methyl-AZADOの開発と展開
2000/12 - 有機合成化学協会研究企画賞触媒的不斉Baylis-Hillman反応の展開と活用に関する研究

Association Membership(s) (7)：

THE JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER , THE JAPANESE CANCER ASSOCIATION , International Society of Heterocyclic Chemistry , American Chemical Society , The Society of Synthetic Organic Chemistry, Japan , The Chemical Society of Japan , The Pharmaceutical Society of Japan

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