Rchr

J-GLOBAL ID：200901065813375268 Update date: Apr. 22, 2024

Shibayama Hirohiko

Affiliation and department：
Other affiliations (1)：

Osaka University

Homepage URL (1)： https://osaka.hosp.go.jp/department/intern/ketueki_g/

Research field (1)： Hematology and oncology

Research keywords (2)：血液・腫瘍内科 , Hematology and Oncology

Research theme for competitive and other funds (51)：

2019 - 2022 Role of mesenchymal stromal cells in multiple myeloma
2019 - 2022 Role of STAP proteins in allogeneic hematopoietic stem cell transplantation
2019 - 2022 Mechanism by which deficiency of hematopoietic stem cell antigen ESAM leads to lethal erythropoietic failure during fetal life
2019 - 2022 Evaluation of iron-sulfur proteins in hematopoietic cells through anamorsin
2017 - 2020 Analysis of the role of Anamorsin in erythrocyte differentiation using conditional knockout mice.

2016 - 2019 Clarification of the roles of anamorsin in the lymphocytes differentiation and proliferation

2014 - 2017 Functional analysis of Anamorsin in iron metabolism in vivo

2014 - 2017 Investigation of eculizumab therapeutic response to patients with PNH

2013 - 2016 Analysis of the functions of anti-apoptotic molecule, Anamorsin -the roles in hematopoiesis and cellular iron metabolism-

2013 - 2016 The analysis of bone marrow microenvironment in myelodysplastic syndrome using patient-derived iPS cells

2013 - 2016 Dendritic cell differentiation from myeloid neoplasm

2013 - 2016 Analysis of the roles of anti-apoptotic molecule, Anamorsin in immune cells

2011 - 2013 Development of novel anti-tumor drugs inhibiting Anamorsin and Picot binding

2010 - 2012 Analysis of functions of anamorsin, an anti-apoptotic molecule, in hematopoiesis

2010 - 2012 Analysis of the roles of anamorsin, anti-apoptotic molecule, onsurvival and proliferation of B lymphocytes

2010 - 2012 Analysis of weak points in oncogenic tyrosine kinase-dependent growth

2010 - 2011 Analysis of leukemogenic transgenic mice generated by tetraploid embryonic complementation method using Tet-off system.

2009 - 2011 Energy metabolism in the growth and differentiation of hematopoietic stem/ progentor cells

2008 - 2010 Roles of leukemogenic oncogenes in the regulation of metabolism, growth, and differentiation of hematopoietic stem cells

2007 - 2008 Clarification of functions of Anamorsin, anti-apoptotic molecule, and its roles in malignant lymphomas

2006 - 2007 新規Gene-Trap法による多段階の白血病発症に関わる遺伝子単離の試み

2006 - 2007 Synthetic Analysis on the mechanisms of survival and differentiation of hematopoietic cells

2006 - 2007 Novel signal transduction pathways in constitutive active mutants of receptor tyrosine kianses

2006 - 2007 The function of Sir2 in proliferation and aging of hematopoietic cells

2006 - 2007 造血細胞における細胞老化克服遺伝子の単離と機能解析

2005 - 2006 Clarification of mechanism of anamorsin, anti-apoptotic molecule

2005 - 2005 Notchの活性化変異による白血病発症機構の解析

2004 - 2005 Analysis on the mechanisms of growth, differentiation, and survival of megakaryocytic cells

2004 - 2005 Analysis on the mechanisms of NF-κB/Reactive Oxigen Species-mediated survival of hematopoietic cells and its clinical application

2004 - 2005 Mechanism of leukemogenesis by constitutive active receptor tyrosine kinase

2004 - 2005 造毛器腫瘍における抗アポトーシス分子アナモルシンの役割

2004 - 2004 細胞周期制御分子による造血幹細胞の未分化能の維持及び増幅の試み

2003 - 2004 Anamorsin, anti-apoptotic molecule, and hematopoiesis

2004 - 抗アポトーシス分子アナモルシンの作用機序の解明

2004 - Identification of Anamorsin binding molecules

2003 - 2003 E2F1による細胞内ROSの蓄積及び癌抑制機構の解析

2003 - 2003 活性化変異c-Kit,Flt3の異常シグナル伝達を標的とした治療法の開発

2002 - 2003 Analysis on the mechanism of survival, growth and differentiation of hematopoietic cells

2002 - 2003 Analysis on the effects of GATA transcription factors on cell cycle regulatoy molecules in hematopoietic cells

2002 - 2003 造血幹細胞におけるテロメラーゼ活性の制御機構の解析と制御分子の単離の試み

2003 - 造血器腫瘍発生における抗アポトーシス分子アナモルシンの役割

2003 - Roles of anti-apoptotic molecule, Anamorsin in hematologic malignancies

2002 - 2002 E2F-1のアポトーシス誘導分子、癌抑制遺伝子としての機能の解析

2001 - 2002 Mechanisms of growth, survival and transformation mediated by KIT and FLT3

2001 - 2001 GATA転写因子群によるサイトカインシグナルの制御機構に関する研究

2001 - 2001 活性酸素種による細胞死誘導と腫瘍細胞での解除機構の解析

2000 - 2001 Establishment of a sensitive method for detection of PIG-A mutations, and some applications for molecular studies of paroxysual necturnal hemoglobinuric

2000 - 2000 巨核球系細胞の増殖・分化分子機構に関する研究

2000 - 2000 活性化変異c-kitレセプターチロシンキナーゼを分子標的とする治療法の開発

2000 - Anti-apoptotic molecule, anamorsin, and hematopoiesis

1990 - 1992 Study of hematopoietic colony inhibitory factor produced by hairy cells

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Papers (235)：

Hirohiko Shibayama, Mitsuhiro Itagaki, Hiroshi Handa, Akihiro Yokoyama, Akio Saito, Satoru Kosugi, Shuichi Ota, Makoto Yoshimitsu, Yasuhiro Tanaka, Shingo Kurahashi, et al. Primary analysis of a prospective cohort study of Japanese patients with plasma cell neoplasms in the novel drug era (2016-2021). International journal of hematology. 2024
Yasunori Kogure, Hiroshi Handa, Yuta Ito, Masaki Ri, Yuichi Horigome, Masaki Iino, Yoriko Harazaki, Takahiro Kobayashi, Masahiro Abe, Tadao Ishida, et al. ctDNA improves prognostic prediction in relapsed/refractory MM receiving ixazomib, lenalidomide, and dexamethasone. Blood. 2024
Ryumei Kurashige, Masako Kurashige, Yosuke Okada, Kohei Higuchi, Sayako Yuda, Akihisa Hino, Takako Miyamura, Michiko Ichii, Kentaro Fukushima, Keiichiro Honma, et al. Differentiating Between Epstein-Barr Virus-positive Lymphoid Neoplasm Relapse and Post-transplant Lymphoproliferative Disorder After Sex-mismatched Hematopoietic Stem Cell Transplantation. The American journal of surgical pathology. 2024
小澤孝幸, 上田智朗, 石川淳, 上田周二, 小杉智, 井上愛, 服部英喜, 倉上弘幸, 福島健太郎, 柴山浩彦, et al. びまん性大細胞型B細胞リンパ腫に対する高齢者総合機能評価を用いたR-CHOP治療成績. 日本血液学会学術集会. 2023. 85回. 709-709
Yuichi Horigome, Masaki Iino, Yoriko Harazaki, Takahiro Kobayashi, Hiroshi Handa, Yasushi Hiramatsu, Taiga Kuroi, Kazuki Tanimoto, Kosei Matsue, Masahiro Abe, et al. A prospective, multicenter, observational study of ixazomib plus lenalidomide-dexamethasone in patients with relapsed/refractory multiple myeloma in Japan. Annals of hematology. 2023

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MISC (138)：

本堂方人, 長手泰宏, 戸田淳, 中谷綾, 柴山浩彦, 上田智朗. 蛋白漏出性胃腸症を契機に診断された濾胞性リンパ腫と骨髄増殖性腫瘍の同時重複症例. 臨床血液. 2023. 64. 2
倉重隆明, 倉重真沙子, 岡田洋介, 樋口紘平, 日野彬央, 宮村能子, 一井倫子, 福島健太郎, 竹内真, 澤田明久, et al. Using ImmunoFISH to determine lymphoid neoplasm relapse after sex-mismatched HSCT or PTLD occurrence(和訳中). 日本血液学会学術集会. 2021. 83回. OS2-2
柴山浩彦. 【再発・難治性多発性骨髄腫治療の最前線-イサツキシマブの登場-】多発性骨髄腫診療の変遷再発・難治性の多発性骨髄腫への治療選択肢と課題. Progress in Medicine. 2021. 41. 3. 239-242
柴山浩彦. 多発性骨髄腫の頻度と予後up-date. 血液内科. 2021. 82. 2. 261-265
土居由貴子, 横田貴史, 柴山浩彦, 松元加奈, 倉重真沙子, 野崎健司, 吉田好機, 菅真紀子, 小池翠, 戸田淳, et al. A case of PTCL-NOS with central nervous system involvement successfully treated with oral forodesine. 日本血液学会学術集会抄録(Web). 2021. 83rd

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Patents (1)：

新規ポリペプチド、新規DNA、新規抗体および新規遺伝子改変動物

Education (2)：

- 1989 Osaka University Faculty of Medicine Medical School
- 1989 Osaka University Faculty of Medicine Medicine

Professional career (1)：

Medical doctor (Osaka University)

Work history (9)：

2021/04 - 現在 Osaka University
2021/04 - 現在 National Hospital Organization Osaka National Hospital Department of Hematology
2017/04 - 2021/03 Osaka University Graduate School of Medicine Department of Hematology and Oncology Vice Professor
2010/06 - 2017/03 Osaka University Graduate School of Medicine Department of Hematology and Oncology Associate Professor
2002/04 - 2010/05 Osaka University Graduate School of Medicine Department of Hematology and Oncology Assistant Professor

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Awards (12)：

2014 - 日本白血病研究基金第24回公益信託日本白血病研究基金骨髄異形成症候群の病態形成における抗アポトーシス分子アナモルシンのはたす役割の解明と診断・治療への応用
2012 - 財団法人三井生命厚生事業団財団法人三井生命厚生事業団第45回「医学研究助成」 PCR法を用いた多発性骨髄腫の骨髄微小残存病変(MRD)測定の妥当性の検討
2009 - 先進医薬研究振興財団先進医薬研究振興財団(血液医学) Bリンパ球の生存・増殖における抗アポトーシス分子アナモルシンの役割の解析
2007 - がん研究助成
2005 - 第15回公益信託日本白血病研究基金

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Association Membership(s) (16)：

アメリカ癌治療学会 , 日本臨床腫瘍学会 , アメリカ血液学会 , 日本癌学会 , 日本臨床血液学会 , 日本血液学会 , 日本内科学会 , American Society of Clinical Oncology , Japanese Society of Medical Oncology , American Society of Hematology , Japanese Society of Cancer Research , Japanese Society of Clinical Hematology , Japanese Society of Hematology , Japanese Society of Internal Medicine , 日本リンパ網内系学会 , 日本骨髄腫学会

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