Masumoto Hiroshi

マスモトヒロシ | Masumoto Hiroshi

Affiliation and department：
Job title：室長
Other affiliations (1)：

(公益財団法人)かずさDNA研究所先端研究開発部・染色体工学研究室室長

Homepage URL (2)： https://www.kazusa.or.jp/laboratories/advanced-department/chromosome-lab/ , http://www.kazusa.or.jp/en-laboratories/en-advanced-department/en-chromosome-lab/

Research field (3)： Cell biology , Molecular biology , Genetics

Research theme for competitive and other funds (31)：

2020 - 2023 Elucidation of plant centromere formation mechanism and development of plant artificial chromosomes
2018 - 2020 Analyses of the chromatin on the genomic repetitive DNA involved in hierarchical and functional structures of the chromosome
2016 - 2019 Centromere modulation coordinating with higher order cellular functions and development of a next generation human artificial chromosome
2016 - 2018 染色体機能形成の階層性とゲノム反復DNA上のクロマチン構造の解明
2011 - 2016 The function of non-coding DNA for genome integrity

2011 - 2016 Analysis of chromatin network involving centromere functional components

2011 - 2014 Analysis of mechanism involved in the assembly balance between centromere chromatin and/or heterochromatin and in higher cellular regulation.

2011 - 2012 Analyses of centromeric chromatin structure

2010 - 2011 Development of the assay system for chromatin regulatory factors using modified centromere DNA

2008 - 2010 The analysis of basic chromosomal functions using human artificial chromosomes (HACs) and the development of novel HACs.

2008 - 2009 染色体分配異常を引き起こすメカニズムの解析

2008 - 2009 染色体分配装置の新規形成メカニズム

2007 - 2008 条件不安定化ヒト人工染色体を用いたセントロメア機能と核再形成の研究

1999 - 2004 染色体機能装置のダイナミクスとアルゴリズム

1999 - 2003 ヒト人工染色体を用いたセントロメアの高次調節機構の解析

1999 - 1999 ヒト人工染色体及び新規セントロメア形成における複製開始点の役割

1999 - 1999 哺乳動物人工染色体を用いた転写調節にかかわるクロマチン構造の解析

1997 - 1998 Construction of mammalian artificial chromosomes using YAC

1997 - 1998 Structural and Functional Analyzes of Human Artificial Chromosomes

1995 - 1998 染色体の核内配置とその要因

1996 - 1996 Construction of mammalian artificial chromosomes using YAC

1995 - 1995 Cloning of functional human centromere DNA by YAC technology

1993 - 1995 Regulation of MPF activation and Institute of Mitosis

1994 - 1994 Development of Human Artificial Chromosome

1994 - ヒト人工染色体(HAC)の構築

1994 - Construction of Human Artificial Chromosome(MAC)

1992 - 1992 ヒト染色体セントロメアに局在するCENPーB蛋白の細胞内及び試験官内での機能解析

1990 - 1992 染色体ドメインの機能構造

1989 - 1990 Functional Structure of Centromere/Kinetochore Domain of Mammalian Chromosomes

1984 - 哺乳動物染色体セントロメアの構造と機能の解析

1984 - Analysis of structure and function of centromeres on mammalian chromosomes.

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Papers (74)：

Shinya Ohta, Jun-Ichirou Ohzeki, Nobuko Sato, Hideki Tanizawa, Claire Yik-Lok Chung, Ken-Ichi Noma, Hiroshi Masumoto. Novel role of zinc-finger protein 518 in heterochromatin formation on α-satellite DNA. Nucleic Acids Research. 2024
Koichiro Otake, Kazuto Kugou, Jekson Robertlee, Jun-ichirou Ohzeki, Koei Okazaki, Shigeru Hanano, Seiji Takahashi, Daisuke Shibata, Hiroshi Masumoto. De novo induction of a DNA-histone H3K9 methylation loop on synthetic human repetitive DNA in cultured tobacco cells. The Plant Journal. 2023
Koei Okazaki, Megumi Nakano, Jun-ichirou Ohzeki, Koichiro Otake, Kazuto Kugou, Vladimir Larionov, William C. Earnshaw, Hiroshi Masumoto. Combination of CENP-B Box Positive and Negative Synthetic Alpha Satellite Repeats Improves De Novo Human Artificial Chromosome Formation. Cells. 2022. 11. 9. 1378-1378
Junichirou Ohzeki, Kazuto Kugou, Koichiro Otake, Koei Okazaki, Seiji Takahashi, Daisuke Shibata, Hiroshi Masumoto. Introduction of a long synthetic repetitive DNA sequence into cultured tobacco cells. Plant Biotechnology. 2022
Kazuhiko S.K. Uchida, Minji Jo, Kota Nagasaka, Motoko Takahashi, Norihisa Shindo, Katsushi Shibata, Kozo Tanaka, Hiroshi Masumoto, Tatsuo Fukagawa, Toru Hirota. Kinetochore stretching-mediated rapid silencing of the spindle-assembly checkpoint required for failsafe chromosome segregation. Current Biology. 2021

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MISC (138)：

大竹興一郎, 久郷和人, 大関淳一郎, JEKSON Robertlee, 岡崎孝映, 花野滋, 花野滋, 高橋征司, 柴田大輔, 舛本寛. De novo induction of DNA-Histone methylation: Application of human chromatin manipulation system to plant cells. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
大関淳一郎, 久郷和人, 岡崎考映, 中野めぐみ, 大竹興一郎, 白澤健太, 磯部祥子, 遠藤裕介, 舛本寛. Revealing histone modifications on the human centromere core region by creating a synthetic chromosome. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
宮野可菜, 白井温子, 眞貝洋一, 大関淳一郎, 舛本寛, 中山学, 阿部訓也, 鈴木伸之介. Construction of ectopic heterochromatic systems in mouse cell. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
大竹興一郎, 大竹興一郎, 久郷和人, 大関淳一郎, ROBERTLEE Jekson, 岡崎孝映, 花野滋, 高橋征司, 柴田大輔, 舛本寛. Gene expression control by chromatin manipulation on a plant chromosome. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
大関淳一郎, 岡崎考映, 中野めぐみ, 大竹興一郎, 白澤健太, 磯部祥子, 舛本寛. Analyzing the human centromere chromatin structure by creating a chromosome. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th

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Patents (2)：

Mammalian Artificial Chromosome
Mammalian Artificial Chromosome

Books (4)：

Properties and interaction of CENP-B and centromere satellite DNA in mammalian cells. In Chromosome Segregation and Aneuploidy.
EC Joint Research Center 1996
Properties and interaction of CENP-B and centromere satellite DNA in mammalian cells. In Chromosome Segregation and Aneuploidy.
EC Joint Research Center 1996
Properties of CENP-B and Its Target Sequence in a Satellite DNA
NATO ASI Series, Edited By Baldev K. Vig, Springer-Verlag 1993
Properties of CENP-B and Its Target Sequence in a Satellite DNA
NATO ASI Series, Edited By Baldev K. Vig, Springer-Verlag 1993

Works (1)：

条件不安定化ヒト人工染色体を用いたセントロメア機能と核再形成の研究
2007 -

Education (2)：

- 1989 Nagoya University
- 1982 International Christian University College of Liberal Arts Division of Natural Sciences

Professional career (1)：

理学博士 (名古屋大学)

Work history (6)：

2009 - 現在 Kazusa DNA Research Institute Department of Frontier Research and Development, Laboratory of Chromosome Engineering
2007 - 2008 - 名古屋大学大学院理学研究科生命理学専攻准教授
2003 - 2006 National Cancer Institute, NIH, USA, Senior Research Fellow
1996 - Nagoya University Graduate School of Science, Division of Biological Science
1995 - Nagoya University School of Science

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Association Membership(s) (2)：

細胞生物学会 , 分子生物学会

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