Rchr
J-GLOBAL ID:200901065923451580   Update date: Jun. 11, 2024

Sakai Norio

サカイ ノリオ | Sakai Norio
Affiliation and department:
Job title: 教授
Research field  (1): Pharmacology
Research keywords  (8): Protein kinase C ,  neurodegenerative disease ,  serotonin transporter ,  spinno cerebellar ataxia ,  protein kinase ,  cell death ,  neuropsychiatric disease ,  neural plasticity
Research theme for competitive and other funds  (23):
  • 2023 - 2025 脂溶性に着目したニコチンによる新たな細胞機能調節機構の探索と解明
  • 2023 - 2025 膜脂質説に基づく静脈麻酔薬の新たな機能発揮メカニズムの解明と臨床応用への展開
  • 2012 - 2014 恒常的cAMPアクチベーターGPR3がα3,α5型ニコチン作動性アセチルコリン受容体の機能に与える影響
  • 2012 - 2013 Development of screening methods to find novel therapeutic drugs for neurodegenerative disease using fluorescence-based probe and high-content microscope.
  • 2010 - 2012 Development of therapeutic strategy for intractable neuropsychiatric disease using chemical chaperones
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Papers (157):
  • Noguchi, Soma, Kajimoto, Taketoshi, Kumamoto, Takuya, Shingai, Masashi, Narasaki, Soshi, Urabe, Tomoaki, Imamura, Serika, Harada, Kana, Hide, Izumi, Tanaka, Sigeru, et al. Features and mechanisms of propofol-induced protein kinase C (PKC) translocation and activation in living cells. FRONTIERS IN PHARMACOLOGY. 2023. 14
  • Narasaki, Soshi, Noguchi, Soma, Urabe, Tomoaki, Harada, Kana, Hide, Izumi, Tanaka, Shigeru, Yanase, Yuhki, Kajimoto, Taketoshi, Uchida, Kazue, Tsutsumi, Yasuo M., et al. Identification of protein kinase C domains involved in its translocation induced by propofol. EUROPEAN JOURNAL OF PHARMACOLOGY. 2023. 955
  • Hide, Izumi, Shiraki, Hiroko, Masuda, Akihiro, Maeda, Takuya, Kumagai, Mayuka, Kunishige, Nao, Yanase, Yuhki, Harada, Kana, Tanaka, Shigeru, Sakai, Norio. P2Y2 receptor mediates dying cell removal via inflammatory activated microglia. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2023. 153. 1. 55-67
  • Mukai, Akari, Irifune, Masahiro, Shimizu, Yoshitaka, Doi, Mitsuru, Kikuchi, Yuka, Katayama, Sotaro, Oue, Kana, Yoshida, Mitsuhiro, Ago, Yukio, Okada, Yoshiyuki, et al. N-methyl-D-aspartate receptors and glycinergic transmission, respectively, mediate muscle relaxation and immobility of pentobarbital in mice. NEUROSCIENCE LETTERS. 2023. 802. 137175-137175
  • Harada, K, Sho, R., Takakura, H., Yokoyama, E., Koyama, R., Yamamoto, Y., Adachi, N., Tanaka, S., Hide, I. and Sakai, N. S-Palmitoylation of the serotonin transporter promotes its cell surface expression and serotonin uptake. Biochemical and Biophysical Research Communications. 2023. 662. 58-65
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Lectures and oral presentations  (122):
  • プロポフォールによる小胞体の形態変化と細胞内カルシウム動態
    (第144回日本薬理学会近畿部会 2024)
  • コーヒーの長期的な過剰摂取による DNA メチル化を介した腸上皮細胞セロトニントランスポーターの発現変動
    (第97回日本薬理学会年会 2023)
  • Propofol とニコチンが誘発する細胞内カルシウム動態-細胞内小器官カルシウムインジケーターCEPIA を用いた観察
    (第97回日本薬理学会年会 2023)
  • PC12 細胞分化において急速に発現する GPR3 の調節メカニズム
    (第97回日本薬理学会年会 2023)
  • Involvement of G protein-coupled receptor 3 in retinal ganglion neuron survival and axonal regeneration following optic nerve crush in mice
    (NEUROSCIECE 2023 2023)
more...
Education (3):
  • 1989 - 1993 Kobe University Graduate School, Division of Medicine Dept of Pharmacology
  • 1979 - 1986 Kobe University Faculty of Medicine
  • 1979 - 1986 Kobe University Faculty of Medicine
Professional career (1):
  • Doctor of Philosophy in Medical Science (Kobe University)
Work history (5):
  • 2019/04/01 - Hiroshima University Graduate School of Biomedical & Health Sciences Professor
  • 2002/04/01 - 2019/03/31 Hiroshima University Graduate School of Biomedical Sciences Professor
  • 1999/11/01 - 2002/03/31 Kobe University Associate Professor
  • 1994/06/01 - 1999/10/31 Kobe University Research Associate
  • 1993/04/01 - 1994/05/31 Japan Society for the Promotion of Science Researcher
Awards (3):
  • 2023/11/11 - 未来を拓く地方協奏プラットフォーム未来博士3分間コンペティション2023審査委員会(審査員長 未来博士3分間コンペティション2023日本語部門 最優秀賞
  • 2022/12/03 - 第96回日本薬理学会年会会長 第96回日本薬理学会 年会優秀発表賞 OpTER: a low-cost method for measuring the transepithelial/endothelial electrical resistance TER of cell layers, which reduces research costs and the burden on us all
  • 2022/03/08 - 第95回日本薬理学会年会年会長 第95回日本薬理学会 年会優秀発表賞 Gs活性化型受容体GPR3がマウス視神経障害後の軸索再生に与える影響
Association Membership(s) (10):
Japan Society for Medical education ,  日本神経精神薬理学会 ,  日本分子生物学会 ,  society for neuroscience ,  日本神経科学会 ,  日本薬理学会 ,  日本神経学会 ,  The Japanese Society of Clinical Pharmacology and Therapeutics ,  日本神経化学会 ,  日本生化学会
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