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J-GLOBAL ID：200901066233098468   Update date: May. 16, 2024

Goto Shinji

ゴトウ シンジ | Goto Shinji
Affiliation and department：
Nagasaki University Graduate School of Biomedical Sciences, Atomic Bomb Disease Institute

About Nagasaki University Graduate School of Biomedical Sciences, Atomic Bomb Disease Institute


Job title： Assistant Professor
Research field  (3)： Radiology ,  Medical biochemistry ,  Pathobiochemistry
Research theme for competitive and other funds  (20)：
  • 2022 - 2025 Evaluating the biological effects of low-dose radiation based on the changes of tissue stem cells and mitochondrial metabolism
  • 2022 - 2025 Molecular and cellular mechanisms about the acquired radioresistance in cancer
  • 2021 - 2024 Epigenetic regulation as novel approach for organ regeneration - Learning from the stress response mechanism
  • 2021 - 2024 A new approach to cancer focusing on mitochondrial calcium
  • 2017 - 2020 Development of drug that both reduce radiation treatment side effects and suppress cancer metastasis
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Papers (111)：
  • Tsuyoshi Kawabata, Reiko Sekiya, Shinji Goto, Tao-Sheng Li. Chronic replication stress invokes mitochondria dysfunction via impaired parkin activity. Scientific reports. 2024. 14. 1. 7877-7877
  • Lina Abdelghany, Tsuyoshi Kawabata, Shinji Goto, Keiichi Jingu, Tao-Sheng Li. Nicaraven induces programmed cell death by distinct mechanisms according to the expression levels of Bcl-2 and poly (ADP-ribose) glycohydrolase in cancer cells. Translational oncology. 2022. 26. 101548-101548
  • Yong Xu, Da Zhai, Shinji Goto, Xu Zhang, Keiichi Jingu, Tao-Sheng Li. Nicaraven mitigates radiation-induced lung injury by downregulating the NF-κB and TGF-β/Smad pathways to suppress the inflammatory response. Journal of radiation research. 2022. 63. 2. 158-165
  • Lan Luo, Chen Yan, Naoki Fuchi, Yukinobu Kodama, Xu Zhang, Goto Shinji, Kiyonori Miura, Hitoshi Sasaki, Tao-Sheng Li. Mesenchymal stem cell-derived extracellular vesicles as probable triggers of radiation-induced heart disease. Stem Cell Research & Therapy. 2021. 12. 1
  • Lina Abdelghany, Xu Zhang, Tsuyoshi Kawabata, Shinji Goto, Nageh El-Mahdy, Keiichi Jingu, Tao-Sheng Li. Nicaraven prevents the fast growth of inflamed tumors by an anti-inflammatory mechanism. Medical oncology (Northwood, London, England). 2021. 39. 1. 7-7
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MISC (21)：
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Books (2)：
  • 別冊 糖尿病研究ストラテジー, glutathione reductase
    秀潤社 1995
  • 別冊 糖尿病研究ストラテジー, glutathione peroxidase
    秀潤社 1995
Lectures and oral presentations  (14)：
  • 放射線によるミトコンドリアの機能障害
    (第63回日本酸化ストレス学会学術集会 2010)
  • グルタチオンS-トランスフェラーゼπの核移行シグナルと機能
    (第82回日本生化学会大会 2009)
  • グルタチオンS-トランスフェラーゼπの核移行シグナルと機能
    (第62回日本酸化ストレス学会学術集会 2009)
  • グルタチオンS-トランスフェラーゼπのミトコンドリア局在と機能
    (第31回日本分子生物学会年会第81回日本生化学会大会合同大会 2008)
  • グルタチオンS-トランスフェラーゼπのミトコンドリア局在と機能
    (第61回日本酸化ストレス学会学術集会 2008)
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Works (2)：
  • グルタチオンS-トランスフェラーゼp の細胞内小器官への移行機構
    2006 - 2008
  • グルタチオンS-トランスフェラーゼπ の細胞内小器官への局在機構と機能
    2008 -
Education (2)：
  • - 1984 Nagasaki University
  • - 1984 Nagasaki University Faculty of Fisheries
Professional career (1)：
  • Doctor(Medical Science) (Nagasaki University)
Work history (10)：
  • 2013/04 - 現在 原爆後障害医療研究所 細胞機能解析部門 助教
  • 1990 - 2003 Nagasaki University School of Medicine
  • 1990 - 2003 Research Associate,School of Medicine,Nagasaki University
  • 2003 - Nagasaki University Graduate School of Biomedical Sciences, Atomic Bomb Disease Institute
  • 2003 - Assistant Professor,Atomic Bomb Disease Institute,Graduate School of Biomedical Sciences,Nagasaki University
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Awards (2)：
  • 2008 - 第61回日本酸化ストレス学会学術集会 優秀演題賞
  • 2008 - The Japanese Society for Free Radical Research Japan, 2008 Poster Award
Association Membership(s) (8)：
日本放射線影響学会 ,  日本酸化ストレス学会 ,  日本癌学会 ,  日本生化学会 ,  The Japan Radiation Research Society ,  The Japanese Society of Lipid Peroxide and Free Radical Research ,  The Japanese Cancer Association ,  The Japanese Biochemical society
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