Mizuguchi Hiroyuki

ミズグチヒロユキ | Mizuguchi Hiroyuki

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： https://www.osaka-ohtani.ac.jp/department/teacher/pharmacy/mizuguhiro.html

Research field (1)： Pharmaceuticals - health and biochemistry

Research keywords (6)：アレルギー疾患 , シグナル伝達 , ヒスタミン , allergic diseases , signal transduction , histamine

Research theme for competitive and other funds (11)：

2020 - 2023 IL-33発現抑制によるアレルギー性鼻炎の好酸球性炎症の抑制:ダニ動物モデル研究
2016 - 2019 Effects of irradiation with narrowband-ultraviolet B on up-regulation of histamine H1 receptor mRNA
2015 - 2018 Molecular mechanism of steroids for the suppression of histamine H1 receptor signaling.
2012 - 2014 Natural medicine-derived suppressor of IL-33 gene expression correlated with eosinophilia
2010 - 2012 Exploring natural resources-derived compounds that suppress up-regulation of histamine H1 receptor gene expression as a diseases-sensitive gene

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Papers (132)：

Shotaro Michinaga, Kiyomi Sonoda, Naoki Inazuki, Manae Ezaki, Hiroki Awane, Kahori Shimizu, Shigeru Hishinuma, Hiroyuki Mizuguchi. Selective histamine H2 receptor agonists alleviate blood-brain barrier disruption by promoting the expression of vascular protective factors following traumatic brain injury in mice. Journal of Pharmacological Sciences. 2022. 150. 3. 135-145
Aurpita Shaha, Rezwanul Islam, Naonobu Tanaka, Yoshiki Kashiwada, Hiroyuki Fukui, Noriaki Takeda, Yoshiaki Kitamura, Hiroyuki Mizuguchi. Betuletol, a Propolis Component, Suppresses IL-33 Gene Expression and Effective against Eosinophilia. Molecules. 2022
Shotaro Michinaga, Kazuya Onishi, Kahori Shimizu, Hiroyuki Mizuguchi, Shigeru Hishinuma. Pharmacological Inhibition of Transient Receptor Potential Vanilloid 4 Reduces Vasogenic Edema after Traumatic Brain Injury in Mice. Biological & pharmaceutical bulletin. 2021. 44. 11. 1759-1766
Hiroyuki Mizuguchi, Yuko Miyamoto, Takuma Terao, Haruka Yoshida, Wakana Kuroda, Yoshiaki Kitamura, Noriaki Takeda, Hiroyuki Fukui. Signaling Pathway of Histamine H1 Receptor-Mediated Histamine H1 Receptor Gene Upregulation Induced by Histamine in U-373 MG Cells. Current Issues in Molecular Biology. 2021. 43. 3. 1243-1254
Seiichi Nakano, Sayaka Yamamoto, Takako Esu, Shiho Naniwa, Yuki Konishi, Tomoharu Wakugawa, Yoshiaki Kitamura, Tatsuya Fujii, Seiichiro Kamimura, Hiroyuki Fukui, et al. Effects of Syo-seiryu-to and Its Constituent Crude Drugs on Phorbol Ester-Induced Up-Regulation of IL-33 and Histamine H1 Receptor mRNAs in Swiss 3T3 and HeLa Cells. Allergies. 2021. 1. 3. 163-175

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MISC (44)：

Hiroyuki Fukui, Hiroyuki Mizuguchi, Yoshiaki Kitamura, Hisao Nemoto, Yoshiki Kashiwada, Noriaki Takeda. Intracellular upstream signals activate histamine H-1 receptor and interleukin-9 gene expression, sensitive to pollinosis. FASEB JOURNAL. 2017. 31
Y. Kitamura, H. Nakagawa, T. Fujii, T. Sakoda, T. Enomoto, H. Mizuguchi, H. Fukui, N. Takeda. EFFECT OF H1-ANTIHISTAMINES ON HISTAMINE H-1 RECEPTOR GENE EXPRESSION IN THE NASAL MUCOSA OF PATIENTS WITH POLLINOSIS INDUCED BYARTIFICIAL EXPOSURE TO CEDAR POLLEN. INFLAMMATION RESEARCH. 2015. 64. S11-S11
H. Fukui, H. Mizuguchi, Y. Kitamura, N. Takeda. IMPROVEMENT OF SYMPTOMS WITH CORRELATIVE SUPPRESSION OF ALLERGIC DISEASE-SENSITIVE GENE EXPRESSION. INFLAMMATION RESEARCH. 2014. 63. S44-S44
北村嘉章, 水口博之, 福井裕行. アレルギー性鼻炎におけるヒスタミンH1受容体の役割 (特集アレルギー性鼻炎の発症メカニズム). 臨床免疫・アレルギー科. 2014. 61. 3. 274-281
Sayaka Yamamoto, Hiroyuki Mizuguchi, Kouki Matsui, Takako Esu, Yoshiaki Kitamura, Takeshi Nabe, Noriaki Takeda, Hiroyuki Fukui. Molecular mechanism of PMA-induced up-regulation of interleukin-33 gene expression in Swiss 3T3 cells. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 96P-96P

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Patents (1)：

アレルギー疾患感受性遺伝子発現抑制作用をもつ抗アレルギー性有機化合物

Books (3)：

新生化学実験講座6 生体膜と膜輸送(上)シナプトソーム
東京化学同人 1992
Enzymes Dependent on Pyridoxal phosphate and other carbonyl compounds as cofactors
pergamon press 1990
Enzymes Dependent on Pyridoxal phosphate and other carbonyl compounds as cofactors
pergamon press 1990

Education (4)：

- 1992 Osaka University
- 1992 Osaka University Graduate School, Division of Medicine
- 1986 Osaka City University Faculty of Science
- 1986 Osaka City University Faculty of Science

Professional career (3)：

Doctor of Philosophy (Osaka University)
Master of Medical Science (Osaka University)
Bachelor of Science (Osaka City University)

Work history (6)：

2017/09 - 現在 Osaka Ohtani University
2015/04 - 現在徳島大学大学院医歯薬学研究部准教授
2006/04 - - 徳島大学大学院ヘルスバイオサイエンス研究部准教授
2006/04 - - Associate Professor, Tokushima University
1992/04 - 2006/03 Osaka Medical College

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Awards (2)：

2008 - JPS論文賞
1996 - JB論文賞

Association Membership(s) (6)：

日本ヒスタミン学会 , 日本アレルギー学会 , 日本薬理学会 , 日本薬学会 , American Society for Biochemistry and Molecular Biology , 日本生化学会

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