2017 - 2020 Screening research of new agonist for oxytocin receptor based on scientific evidence based on brain nervous system
2017 - 2019 巨大ゲノム生物の毒生合成マシナリー探索とゲノム解析の基盤技術開発
2015 - 2018 麻痺性貝毒を生産する渦鞭毛藻の毒生合成調節の分子機構
2014 - 2017 Elucidation of biosynthetic pathways towards tetrodotoxin and saxitoxin based on the structures of novel biosynthetic intermediates
2014 - 2016 Preparation of the first antibody against carotenoids and elucidation of their target molecules in tissues and cells by visualization
2012 - 2015 麻痺性貝毒生産渦鞭毛藻のオミクス統合解析による無毒化機構の解明
2009 - 2011 渦鞭毛藻の無毒変異メカニズム解明のための一細胞ライブラリーの構築
2007 - 2009 二枚貝の麻痺性貝毒変換酵素遺伝子の探索と分子進化解析
2005 - 2008 渦鞭毛藻の麻痺性貝毒生合成遺伝子解明をめざした分子生物学的基盤技術の開発
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Papers (66):
Yuko Cho, Shizu Hidema, Takuo Omura, Shigeki Tsuchiya, Keiichi Konoki, Yasukatsu Oshima, Mari Yotsu-Yamashita. Intracellular abundance, localization, and enzymatic activity of a saxitoxin biosynthesis enzyme, SxtG, in two sister subclones of the dinoflagellate Alexandrium catenella with extremely different levels of paralytic shellfish toxins. Harmful Algae. 2024. 139. 102723-102723
Masato Terauchi, Yuki Komazaki, Atsushi Yoshino, Yuko Cho, Yuta Kudo, Mari Yotsu-Yamashita, Keiichi Konoki. Assay for okadaic acid O-acyl transferase using HPLC-FLD. Bioscience, Biotechnology, and Biochemistry. 2024. 88. 9. 999-1006
Mayu Hakamada, Chihiro Tokairin, Hayate Ishizuka, Kanna Adachi, Toma Osawa, Shiori Aonuma, Ryosuke Hirozumi, Shigeki Tsuchiya, Yuko Cho, Yuta Kudo, et al. Synthesis and Identification of decarbamoyloxySaxitoxins in Toxic Microalgae and their Reactions with the Oxygenase, SxtT, Reveal Saxitoxin Biosynthesis. Chemistry - A European Journal. 2024. 30. 18. e202304238
Keita Yamaki, Kyoka Sato, Yuta Kudo, Yuko Cho, Keiichi Konoki, Tomohiro Takatani, Osamu Arakawa, Kentaro Kawatsu, Mari Yotsu-Yamsahita. The quite low cross-reactivity of Kawatsu's anti-tetrodotoxin monoclonal antibody to 5,6,11-trideoxytetrodotoxin, 11-nortetrodotoxin-6(S)-ol, and 11-oxotetrodotoxin, the major tetrodotoxin analogues in pufferfish. Toxicon. 2023. 107081-107081
Yuko Cho, Shigeki Tsuchiya, Takuo Omura, Kazuhiko Koike, Keiichi Konoki, Yasukatsu Oshima, Mari Yotsu-Yamashita. Metabolic inhibitor induces dynamic changes in saxitoxin biosynthesis and metabolism in the dinoflagellate Alexandrium pacificum (Group IV) under in vivo labeling condition. Harmful Algae. 2023. 122. 102372-102372