Rchr
J-GLOBAL ID：200901066937162633
Update date: Sep. 17, 2024
ISHIHARA Hisamitsu
イシハラ ヒサミツ | ISHIHARA Hisamitsu
Affiliation and department：
Job title：
Professor
Research field (1)：
Metabolism and endocrinology
Research keywords (1)：
pathogenesis of diabetes mellitus
Research theme for competitive and other funds (21)：
- 2020 - 2023 膵島ホルモン分泌細胞の代謝特性の解析と偽膵島作製による代謝・分泌障害機構の解明
- 2017 - 2020 Elucidation of insulin secretory mechanisms through large scale generation of genetically-modified insulin secreting cells and omics analysis
- 2012 - 2015 Analysis of glucagon seceretion mechanisms and its modulation by anti-diabetes drugs
- 2010 - 2012 Molecular mechanism of regulation of expression and identificati on of novel target gene of vitamin D in the pancreas
- 2009 - 2011 Molecular mechanisms of pancreaticβ-cell failure and insulin resistance due to impaired ER stress response
- 2007 - 2010 Pancreatic β cell impairment and adaptation of type 2 diabetes mellitus in overnutrition era
- 2007 - 2008 The molecular mechanisms of transcriptional and translational control of stress responses in pancreatic β cells
- 2006 - 2008 動脈硬化早期診断法の確立-血管壁の電子的染色法を用いて
- 2006 - 2007 ミトコンドリア遺伝子異常糖尿病に対する遺伝子治療の開発
- 2005 - 2006 Signaling axis of urotensin II, parasympathetic nerves, and nitric oxide on carbohydrate metabolism: A clinical
- 2005 - 2006 Molecular Mechanisms for Pancreatic Islet Disfunction in Development of Diabetes Mellitus-a study using WFS1 knockout mice
- 2005 - 2006 Molecular mechanisms for pancreatic beta cell failure・a viewpoint from endoplasmic reticulum stress
- 2004 - 2005 膵ラ島β細胞ミトコンドリアを標的とする遺伝子治療の開発
- 2004 - 2005 The role of genes of forkhead transcription factors in type2 diabetes and obesity.
- 2004 - 2005 Elucidation of abnormality of plasma membrane microdomain in type 2 diabetes mellitus
- 2001 - 2005 Elucidation of diabetes-related genes
- 2003 - 2004 転写ターゲティングシステム構築による膵島ホルモン分泌制御機構の解析と遺伝子治療
- 2003 - 2004 Development of gene therapy for diabetes associated with obesity
- 2002 - 2003 The role of phospholipase D in the development of diabetes mellitus
- 2002 - 2003 The role of plasma membrane type sialidase gene Neu3 on the pathogenesis of type 2 diabetes mellitusin Japanese.
- 遺伝子改変インスリン分泌細胞株の効率的作製法開発とインスリン分泌機構解明への応用
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Papers (142)：
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Takeshi Yamamotoya, Yukino Ohata, Yasuyuki Akasaka, Shun Hasei, Masa-Ki Inoue, Yusuke Nakatsu, Machi Kanna, Hiroki Yamazaki, Akifumi Kushiyama, Midori Fujishiro, et al. Trk-fused gene plays a critical role in diet-induced adipose tissue expansion and is also involved in thyroid hormone action. PNAS nexus. 2024. 3. 4. pgae150
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Midori Fujishiro, Sho Tanaka, Kentaro Watanabe, Kazuhiro Imatake, Yasuyuki Suzuki, Hisamitsu Ishihara, Shigemasa Tani. Association of Glycated Hemoglobin Level with Self-Reported Chewing Problems in Elderly Community-Dwelling Individuals in Japan. Journal of Multidisciplinary Healthcare. 2023. 16. 1231-1238
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Aya Tanaka, Minami Kosuda, Midori Yamana, Asami Furukawa, Akiko Nagasawa, Midori Fujishiro, Genta Kohno, Hisamitsu Ishihara. A large-scale functional analysis of genes expressed differentially in insulin secreting MIN6 sublines with high versus mildly reduced glucose-responsiveness. Scientific Reports. 2023. 13. 1
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Tomofuji Y, Suzuki K, Kishikawa T, Shojima N, Hosoe J, Inagaki K, Matsubayashi S, Ishihara H, Watada H, Ishigaki Y; BioBank Japan Project; Inohara H, et al. Identification of serum metabolome signatures associated with retinal and renal complications of type 2 diabetes. Commun Med. 2023. 5. 1. 5-5
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Tanaka S, Fujishiro M, Imatake K, Suzuki Y, Ishihara H, Tani S. Impact of Female Sex on the Susceptibility to Hypernatremia Among Older Community-Dwelling Individuals in Japan. Int J Gen Med. 2022. 15. 777-785
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MISC (51)：
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Hisamitsu Ishihara, Hidenori Nishioka, Midori Yamana, Akiko Nagasawa, Minami Kosuda, Masao Koike, Genta Kohno, Hitoki Saito. Roles of Glycolysis Distinct from Mitochondrial Metabolism for Signal Generation in Insulin-Secreting Cells. DIABETES. 2020. 69
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西岡秀典, 山名碧, 長澤瑛子, 小須田南, 渡邉健太郎, 石原寿光. ミトコンドリアピルビン酸輸送担体欠損インスリン分泌細胞株の樹立と解析. 糖尿病(Web). 2020. 63. Suppl
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藤城緑, 藤城緑, 櫛山暁史, 小川克彦, 小川克彦, 渡邉健太郎, 江頭富士子, 岡本真由美, 岡本真由美, 村瀬貴代, et al. 2型糖尿病を対象としたプリン体代謝関連物質の血管合併症発症および進展に対する影響の研究(続報). 糖尿病(Web). 2020. 63. Suppl
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山名碧, 長澤瑛子, 小須田南, 山口賢, 江頭富士子, 藤城緑, 渡邉健太郎, 石原寿光. MIN6細胞における解糖系中間体によるインスリン産生制御. 糖尿病(Web). 2019. 62. Suppl
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藤城緑, 藤城緑, 櫛山暁史, 小川克彦, 小川克彦, 山口賢, 渡邉健太郎, 村瀬貴代, 中村敬志, 赤利精悟, et al. 2型糖尿病を対象としたプリン体代謝関連物質の血管合併症発症および進展に対する影響の研究. 糖尿病(Web). 2019. 62. Suppl
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Books (8)：
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糖尿病専門医研修ガイドブック
診断と治療社 2017
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内科学(第11版)
朝倉書店 2017
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ER stress and apoptosis in β cells during the development of diabetes mellitus
2009
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Molecular diabetology: Generation of insulin secretory signals in the mitochondria of β-cells
2009
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The evolution of research on insulin secretion by mitochondria: derived factors
2008
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Lectures and oral presentations (51)：
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Therapy combining glucagon-like peptide-1 receptor agonist with sodium-glucose cotransporter 2 Inhibitor suppresses atherosclerosis in diabetic ApoE-deficient mice
(Exp Clin Endocrinol Diabetes 2024)
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2型糖尿病と続発性高トリグリセリド血症を発症したウエイトリフティング学生選手の1例
(日本成人病(生活習慣病)学会会誌 2024)
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急性膵炎の治療後に発症し,心筋炎を合併した劇症1型糖尿病の一例
(糖尿病 2023)
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肥満2型糖尿病を発症した成人フェニルケトン尿症の一例
(日本病態栄養学会誌 2023)
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急性膵炎の治療後に発症し,心筋炎を合併した劇症1型糖尿病の一例
(糖尿病(Web) 2023)
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Education (1)：
- - 1988 The University of Tokyo Faculty of Medicine
Awards (1)：
- 2009/05 - The Lilly Award The Molecular Mechanisms of Pancreatic Beta-cell Failure in Type 2 Diabetes Mellitus
Association Membership(s) (7)：
米国糖尿病学会
, 日本生化学学会
, 日本成人病学会
, 日本糖尿病合併症学会
, 日本内分泌学会
, 日本糖尿病学会
, 日本内科学会
