Itoh Yasushi

イトウヤスシ | Itoh Yasushi

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： http://www.shiga-med.ac.jp/~hqpatho2/

Research field (6)： Experimental pathology , Immunology , Virology , Laboratory animal science , Human pathology , Cell biology

Research keywords (8)： COVID-19 , 早期老化症候群 , 霊長類モデル , Tリンパ球 , 抗原提示 , サイトカイン , ワクチン , インフルエンザウイルス

Research theme for competitive and other funds (21)：

2022 - 2027 霊長類モデルを用いたワクチン評価に関するサポート機関
2019 - 2022 Study on molecular mechanism of collagen-induced arthritis in cynomolgus monkeys
2019 - 2022 Galectin-3による生体内幹細胞障害の機序解明と治療効果の検証
2019 - 2022 Development of diagnosis and therapy for aging using a nonhuman primate model of premature aging
2019 - 2022 Mechanism of plasma membrane expression of endoplasmic reticulum chaperone proteins

2021 - 2022 Analysis of immune responses and search for therapeutic and vaccine targets against SARS-CoV-2 and seasonal coronavirus using a nonhuman primate model with severe diseases

2021 - 2022 Establishment of infrastructure for promotion of development of antiviral drugs and vaccines against COVID-19 using a nonhuman primate model

2020 - 2021 カニクイザルモデルを用いた新型コロナウイルスに対する組換えワクチンの開発

2017 - 2020 Treatment of DSS colitis with MSCs derived from MHC-homozygous iPSCs with using cynomolgus macaque

2015 - 2018 Search for host factors in severe influenza virus infection using a nonhuman primate model

2014 - 2017 Development of a premature aging syndrome non-human primate model

2014 - 2016 Treatment by a column absorbing immunosuppressing cells in macaques with endometriosis

2011 - 2013 Development of a non-human primate autoimmune model using autoreactive lymphocytes derived from induced pluripotent stem cells

2010 - 2012 Establishment of a macaque cancer model using cancer cells derived from MHC homozygous macaque iPS cells

2010 - 2012 Antibody therapy against novel influenza virus infection using anImmunosuppressed non-human primate model

2008 - 2012 Establishment of a network of model-monkey supply forhuman medical researches

2009 - 2011 Elucidation of MHC polymorphism information in cynomolgus macaque(Macaca Fascicularis)

2001 - 2002 リンパ系における脱リン酸化酵素の研究

2001 - 2001 分泌型TGF-βレセプターII遺伝子導入アデノウイルス投与による腫瘍拒絶の試み

2000 - Tリンパ球の抗原認識とシグナル伝達機構の研究

2000 - Tリンパ球による免疫学的記憶の研究

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Papers (122)：

Shogo Takahata, Tomoko Kato, Daijiro Yanagisawa, Haruka Tsubaki, Zulzikry Hafiz Abu Bakar, Ken-ichi Mukaisho, Yasushi Itoh, Ikuo Tooyama. Immunohistochemical Study of Human Mitochondrial Ferritin in the Substantia Nigra Following Subarachnoid Hemorrhage. ACTA HISTOCHEMICA ET CYTOCHEMICA. 2024. 57. 3. 101-108
Cong Thanh Nguyen, Misako Nakayama, Hirohito Ishigaki, Yoshinori Kitagawa, Akemi Kakino, Marumi Ohno, Masashi Shingai, Yasuhiko Suzuki, Tatsuya Sawamura, Hiroshi Kida, et al. Increased expression of CD38 on endothelial cells in SARS-CoV-2 infection in cynomolgus macaques. Virology. 2024. 594. 110052-110052
Hirohito Ishigaki, Sayaka Ito, Takako Sasamura, Hideaki Ishida, Misako Nakayama, Cong Thanh Nguyen, Takaaki Kinoshita, Shingo Suzuki, Chizuru Iwatani, Hideaki Tsuchiya, et al. MHC-DRB alleles with amino acids Val11, Phe13, and the shared epitopes promote collagen-induced arthritis and a rapid IgG1 response in Filipino cynomolgus macaques. HLA. 2024. 103. 1. e15316
Shino Shimizu, Misako Nakayama, Cong Thanh Nguyen, Hirohito Ishigaki, Yoshinori Kitagawa, Fumihiko Yasui, Yoshiki Yagi, Tomoe Kusayanagi, Michinori Kohara, Yasushi Itoh, et al. SARS-CoV-2 induces inflammation and intracranial infection through the olfactory epithelium-olfactory bulb pathway in non-human primates. Journal of Neuroimmunology. 2024. 578288-578288
Eri Kawakami, Norikazu Saiki, Yosuke Yoneyama, Chiharu Moriya, Mari Maezawa, Shuntaro Kawamura, Akiko Kinebuchi, Tamaki Kono, Masaaki Funata, Ayaka Sakoda, et al. Complement factor D targeting protects endotheliopathy in organoid and monkey models of COVID-19. Cell stem cell. 2023. 30. 10. 1315-1330

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MISC (156)：

伊藤靖. 霊長類モデルを用いたワクチン有効性評価. 実験動物ニュース. 2024. 73. 76-80
M Nakayama, H Ishigaki, N Thanh Cong, S Suzuki, H Ishida, N Kitagawa, K Ogasawara, Y Itoh. Long-term efficacy of an inactivated whole particle H5N1 virus against H5N1 highly pathogenic avian influenza virus challenge in cynomolgus monkeys. European Respiratory Journal. 2022. 60 (suppl 66). 662-662
清水志乃, 仲山美沙子, 石垣宏仁, Nguyen Thanh Cong, 北川善紀, 伊藤靖, 清水猛史. サルにおける嗅上皮から嗅神経を介したSARS-CoV-2の頭蓋内感染について. 日本鼻科学会会誌. 2022. 61. 3. 551-551
清水志乃, 仲山美沙子, 石垣宏仁, NGUYEN Thanh Cong, 北川善紀, 伊藤靖, 清水猛史. サルにおける嗅上皮から嗅神経を介したSARS-CoV-2の頭蓋内感染について. 日本鼻科学会会誌(Web). 2022. 61. 3
安井文彦, 松本祐介, 石垣宏仁, 仲山美沙子, 山本直樹, 真田崇弘, 山地賢三郎, THANH Nguyen Cong, 本田智子, 北川善紀, et al. 高度弱毒化ワクシニアウイルスベクターDIsを用いたCOVID-19ワクチンの交差反応性と長期免疫持続効果の検討. 日本ワクチン学会学術集会プログラム・抄録集. 2022. 26th

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Patents (2)：

IMMUNOSUPPRESSIVE CELL-CAPTURING MATERIAL AND IMMUNOSUPPRESSIVE CELL-CAPTURING COLUMN
免疫抑制細胞捕集材及び免疫抑制性細胞捕集用カラム

Books (2)：

創薬研究者がこれだけは知っておきたい最新のウイルス学
技術情報協会 2021
脱リン酸化酵素のTリンパ球における役割
上原記念生命科学財団研究報告集 2002

Education (2)：

- 1994 Hokkaido University
- 1990 Hokkaido University School of Medicine

Professional career (1)：

M.D., PhD (Hokkaido University)

Work history (8)：

2019/11 - 現在 Shiga University of Medical Science
2000/03 - 2019/10 Shiga University of Medical Science
1999 - 2000 アメリカ国立衛生研究所客員研究員
1997 - 1999 日本学術振興会 NIH特別研究員
1997 - 1999 Researcher, Japan Society for the Promotion of Science

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Committee career (2)：

2016/10 - 現在日本免疫学会評議員
2014 - 現在日本病理学会学術評議委員

Awards (2)：

2014 - 日本病理学会学術研究賞
1995 - 北海道医学会賞

Association Membership(s) (5)：

日本ワクチン学会 , 日本癌学会 , 日本ウイルス学会 , 日本病理学会 , 日本免疫学会

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