Rchr
J-GLOBAL ID：200901067063367694
Update date: Nov. 14, 2024
HATTORI Yoshiyuki
ハットリ ヨシユキ | HATTORI Yoshiyuki
Affiliation and department：
Job title：
Professor
Homepage URL (2)：
https://www.hoshi.ac.jp/laboratory/yakuzaigaku/
,
https://jupiter.hoshi.ac.jp/lab/yakuzai/hattori%20(E).htm
Research field (1)：
Clinical pharmacy
Research keywords (6)：
Liposome
, Gene therapy
, Nucleic acids-based therapeutics
, Gene delivery
, Tumor therapy
, Drug delivery system
Research theme for competitive and other funds (14)：
- 2024 - 2027 Development of mRNA lipid nanoparticles for tumor vaccine
- 2020 - 2023 静脈内投与によりがん組織へsiRNAを送達するための葉酸修飾リポソーム製剤の開発
- 2017 - 2020 Development of siRNA therapy for liver metastasis by sequential injection of chondroitin sulfate and siRNA lipoplex
- 2014 - 2017 siRNA delivery to cancer tissue by sequential injection of anionic polymer and siRNA lipoplex
- 2012 - 2015 Development of PEGylated Histone Deacetylase Inhibitor Having Prolonged Blood Retention and EPR effect
- 2012 - 2015 Advanced drug discovery research on dyslipidemia treatment targeting visceral fat
- 2012 - 2014 Development of lipid-based nanoparticle for siRNA delivery to the central nervous system and tumor with high gene silencing effect and safety
- 2012 - 2014 Development of delivery system of nucleic acid-based medicine against refractory cancer resistant to endocrine therapy
- 2011 - 2014 Evaluation of antitumor effect of tumor-associated macrophage-targeting liposomes
- 2009 - 2012 Development of cationic histone deacetylase inhibitors as enhancer of gene transfection and expression
- 2008 - 2011 Angiotensin II-induced hypertension enhanced delivery of liposomal anti-cancer drugs into tumor
- 2007 - 2009 Synthesis of Histone Deacetylase Inhibitors Toward the Development of DDS
- 2006 - 2008 Development of inflammation-targeting vectors of decoy oligonucleic acid for inflammatory disease therapy
- 2004 - 2006 Development of folate-modified lipid-based nanoparticles for suicide gene therapy to prostate cancer
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Papers (117)：
-
Yoshiyuki Hattori, Min Tang, Junnosuke Sato, Makoto Tsuiji, Kumi Kawano. Evaluation of mRNA lipoplexes prepared using modified ethanol injection method as a tumour vaccine. Journal of Drug Targeting. 2024. 32. 10. 1267-1277
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Yoshiyuki Hattori, Min Tang. Effect of cationic and neutral lipids in cationic liposomes on antibody production induced by systemic administration of mRNA lipoplexes into mice. Journal of Drug Delivery Science and Technology. 2024. 100. 106034
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Yoshiyuki Hattori, Min Tang, Hanaka Suzuki, Ayana Hattori, Sora Endo, Ayumu Ishii, Aya Aoki, Momoka Ezaki, Hana Sakai. Optimization of transfection into cultured cells with siRNA lipoplexes prepared using a modified ethanol injection method. Journal of Drug Delivery Science and Technology. 2024. 99. 106000
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Andang Miatmoko, Devy Maulidya Cahyani, Kumi Kawano, Yoshiyuki Hattori. Comparative cellular and in vivo anti-cancer studies of doxorubicin liposomes prepared with different types of phospholipids. Indonesian Journal of Pharmacy. 2024. 35. 3. 459-466
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Min Tang, Yoshiyuki Hattori. Effect of vorinostat on protein expression in vitro and in vivo following mRNA lipoplex administration. Biomedical Reports. 2024. 21. 1. 105
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MISC (14)：
Patents (6)：
Books (5)：
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遺伝子治療・診断の最先端技術と新しい医薬品・診断薬の開発
技術情報協会 2014
-
The Drug Delivery System
2012
-
Encyclopedia of Nanoscience and Nanotechnology, edited by H. S. Nalwa
American Scientific Publishers 2011
-
Oral Cancer Research Advances, edited by Alexios P. Nikolakakos
Nova Science Publishers, Inc. 2007
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Nanotechnologies for the Life Science, Biofunctionalization of nanomaterials, edited by Challa. Kumar
Wiley-VCH 2005
Lectures and oral presentations (221)：
-
修正エタノール注入法により調製したmRNAリポプレックスのマウス静注後の抗体産生に及ぼす正電荷脂質と中性脂質の組み合わせの影響
(日本薬剤学会年会講演要旨集(CD-ROM) 2024)
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Preparation of liposomes co-encapsulating doxorubicin and sorafenib for the treatment of drug-resistant tumor
(日本薬学会年会要旨集(Web) 2024)
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Effect of cationic lipid, neutral helper lipid, and PEG-lipid on gene-knockdown efficacy after transfection with siRNA lipoplexes prepared by modified ethanol injection method
(日本薬学会年会要旨集(Web) 2024)
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Effect of solvents for preparation of siRNA lipoplexes using modified ethanol injection method on gene-knockdown efficacy in the cells
(日本薬学会年会要旨集(Web) 2024)
-
Antitumor effect of liposomes co-encapsulating doxorubicin and mifepristone on the drug-resistant tumor cells
(日本薬学会年会要旨集(Web) 2024)
ｍore...
Education (1)：
- 1996 - 1999 Kyoto University Graduate School of Pharmaceutical Science
Professional career (1)：
- Doctor (Kyoto University)
Work history (9)：
- 2020/04 - 現在 Hoshi University Department of Molecular Pharmaceutics Professor
- 2019/08 - 2020/03 Hoshi University Department of Pharmaceutics Professor
- 2018/01 - 2019/07 Hoshi University Department of Drug Delivery Research Professor
- 2015/04 - 2017/12 Hoshi University Department of Drug Delivery Research Associate Professor
- 2009/05 - 2015/03 Hoshi University Institute of Medicinal Chemistry Associate professor
- 2005/07 - 2009/04 Hoshi University Institute of Medicinal Chemistry Lecturer
- 2002/04 - 2005/06 Hoshi University Institute of Medicinal Chemistry Assistant Professor
- 1999/04 - 2002/03 Tosoh Corporation
- 1999/04 - 2001/04 Kyoto University Hospital Department of Medicine and Clinical Science, Postdoctoral Researcher
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Committee career (2)：
- 2023/02 - 現在 日本薬学会関東支部 幹事
- 2018/04 - 現在 日本薬剤学会 代議員
Awards (5)：
- 2019/03 - European Conference on Pharmaceutics JDDST 2018 Best paper award
- 2009/10 - The Pharmaceutical Society of Japan Kanto Branch Award for Young Scientists
- 2009/05 - 星薬科大学 大谷記念研究助成金 脂質ナノ粒子を用いた癌遺伝子治療法の開発
- 2001/07 - The Japan Endocrine Society Young Investigator Awards
- 1999/09 - American Thyroid Association Travel Grant
Association Membership(s) (3)：
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