Kawai Kensuke

カワイケンスケ | Kawai Kensuke

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://plaza.umin.ac.jp/~kenkawai/

Research field (7)： Neurosurgery , Biomaterials , Biomedical engineering , Otorhinolaryngology , Clinical pharmacy , Physiology , Neuroscience - general

Research keywords (32)：砂ネズミ , 側頭葉てんかん , ラット , 軟膜下皮質多切術 , 難治性てんかん , 大脳皮質 , スフィンゴシン1リン酸 , GABA , AMPA型受容体 , Seizure , glutamic acid decarboxylase , 機能脳神経外科学 , 皮質脳波 , 術中皮質脳波 , 聴原性痙攣 , 機能温存的治療 , グルタミン酸受容体 , 易痙攣性 , 迷走神経刺激療法 , immunocy tochemistry , inferior colliculus , cerebral ischemia , 一過性全脳虚血 , 心肺蘇生 , 局所脳虚血 , アポトーシス , 視床 , 遅発性神経細胞死 , 脳虚血 , 記憶 , 海馬 , てんかん

Research theme for competitive and other funds (25)：

2023 - 2026 Elucidation of upward modulatory mechanisms of cerebral cortices via thalamus for its clinical application
2021 - 2024 臓器感覚入力系におけるモノアミン神経細胞の情動表現解析
2020 - 2023 Multi-scale investigation of cerebral anatomo-functional changes induced by long-term electrical stimulation and surgical intervention
2019 - 2022 Neurofeedback based on invasive BMI using multiscale neural information in vocalization
2016 - 2020 Communication support Brain Machine Interface using visual response

2017 - 2020 てんかんと記憶に関わる脳内機能的結合性の特性抽出と外科的及び電気刺激による介入

2014 - 2018 Traslational study of vagus nerve stimulation

2014 - 2016 Evaluation of physiological and pathological brain activities by simultaneous recording of single unit and intracranial EEG

2012 - 2015 Signal decoding by templates of human brain function and standalization of imaging and electrophysiology

2011 - 2014 in vitro reconstruction of the NE/5-HT neuromodulation system for studying vagus nerve stimulation

2009 - 2012 Development of functional brain treatment system by integrating white matter tractographies of the brain

2009 - 2012 Comprehensive study on the development of novel methods for localization and treatment of epilepsy focusing on the abnormal synchronization of neural network

2005 - 2006 Validation of the motor/language functional localizations by functional neuroimaging and tractographyby-integrated neuronavigation

2004 - 2006 Changes in intraoperative electrocorticography after various partial resection and disconnection of the medial temporal structures - toward elucidation of the medial temporal epiloptogenic unit and development of a new function-preserving surgical treatme

1999 - 2001 Higher brain function changes after selective amygdala-hippocampai radiosurgery in medial temporal lobe epilepsy : Relationship between neuropsychological findings and functional MRI

1999 - 2000 アポトーシス抑制タンパク質による虚血脳保護に関する研究

1999 - 2000 Elucidation of the Mechanisms for Glutamate Release in Ischemic Neuronal Injury

1999 - 2000 虚血性神経細胞死におけるGluR_2仮説の検証

1997 - 1998 Changes of sphingosine-1-phosphate in delayed neuronal death

1996 - 1998 Study of functional resection of cirtical epileptogenic foci by cortical cooling

1994 - 1997 Study of mechanism of ischemic neuronal death.a molecular biological approach

1994 - 1996 Ischemic neuronal cell damage and iron metaoblism

1994 - 1996 心臓蘇生後脳症と痙攣発生のメカニズムに関する研究

1994 - 1995 Molecular basis for ischemic cochlear dysfunction

難治性てんかんに対する新しい治療法の開発、記憶のfMRIの臨床応用、頭蓋内脳波解析

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Papers (215)：

Tomoya Yagisawa, Kenji Ibayashi, Rintaro Kuroda, Shunsuke Koyama, Yoshinobu Kanda, Yukiko Fukuda, Katsuyuki Shirai, Hirotoshi Kawata, Naoto Kunii, Kensuke Kawai. De novo primary malignant lymphoma of the dura following recurrent episodes of subdural abscess presenting as chronic subdural hematoma: illustrative case. Journal of neurosurgery. Case lessons. 2024. 8. 4
井林賢志, 國井尚人, 川合謙介. 【ニューロモデュレーション最前線】迷走神経刺激療法. 臨床精神医学. 2024. 53. 7. 891-898
Yoshihide Sehara, Yuki Hashimotodani, Ryota Watano, Kenji Ohba, Ryosuke Uchibori, Kuniko Shimazaki, Kensuke Kawai, Hiroaki Mizukami. Adeno-associated Virus-mediated Ezh2 Knockdown Reduced the Increment of Newborn Neurons Induced by Forebrain Ischemia in Gerbil Dentate Gyrus. Molecular neurobiology. 2024
Makoto Satoh, Takeshi Nakajima, Keisuke Ohtani, Hirofumi Oguma, Akira Gomi, Kensuke Kawai. Chronic Subdural Hematoma after Endoscopic Third Ventriculostomy for Chronic Obstructive Hydrocephalus: A Case Report. NMC case report journal. 2024. 11. 201-206
Chaoyi Qin, Frederic Michon, Yoshiyuki Onuki, Yohei Ishishita, Keisuke Otani, Kensuke Kawai, Pascal Fries, Valeria Gazzola, Christian Keysers. Predictability alters information flow during action observation in human electrocorticographic activity. Cell reports. 2023. 42. 11. 113432-113432

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MISC (388)：

大谷啓介, 佐藤信, 石下洋平, 五味玲, 川合謙介. A case in which frontal lobe disconnection was effective not only for seizure suppression but also for improvement of psychiatric symptoms for intractable epilepsy associated with tuberous sclerosis. てんかん研究. 2021. 39. 2
佐藤信, 大谷啓介, 手塚正幸, 石下洋平, 中嶋剛, 川合謙介. Consideration on the focus of olfactory epileptic auras: case studies. てんかん研究. 2021. 39. 2
石下洋平, 川合謙介. Vagus nerve stimulation for treatment of epilepsy. 最新精神医学. 2021. 26. 5
石下洋平, 川合謙介. 小児神経学-現在から未来へ最新の治療てんかん外科治療の適切なタイミング. 小児内科. 2020. 52. 3
大谷啓介, 川合謙介, 五味玲, 佐藤信, 内山拓, 大貫良幸, 石下洋平. Current states of epilepsy care in rural districts in Japan. 月刊精神科. 2020. 36. 6

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Books (5)：

臨床てんかん学 = Clinical epileptology
医学書院 2015 ISBN:9784260021197
術中の側頭葉内側部分切除または離断による皮質脳波変化の検討 : 側頭葉内側のてんかん原性ユニットの解明と新しい機能温存的治療法の開発へ向けて
川合謙介 2007
アポトーシス抑制蛋白質による虚血脳保護に関する研究
斉藤延人 2001
虚血性神経細胞障害におけるグルタミン酸放出機構の解明
桐野高明 2001
遅発性神経細胞死におけるスフィンゴシン1リン酸の変動について
川合謙介 1999

Education (1)：

- 1987 The University of Tokyo Faculty of Medicine School of Medicine

Professional career (1)：

医学博士 (東京大学)

Work history (10)：

2022/04 - 現在自治医科大学附属病院長
2016/01 - 現在 Jichi Medical University Department of Neurosurgery Professor
2013/09 - 2015/12 NTT Medical Center Tokyo Neurosurgery Director
2013/09 - 2015/12 Tokyo Healthcare University
2008/06 - 2013/08 University of Tokyo Graduate School of Medicine Neurosurgery Associate Professor

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Committee career (3)：

2021/09 - 日本てんかん学会理事長
日本てんかん外科学会世話人
日本脳神経外科学会代議員

Awards (2)：

1999 - 日本脳卒中学会草野賞
1993 - 日本脳神経外科学会ガレヌス賞

Association Membership(s) (5)：

日本神経科学会 , JAPANESE SOCIETY OF NEUROLOGY , 日本てんかん外科学会 , 日本てんかん学会 , 日本脳神経外科学会

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