Rchr
J-GLOBAL ID：200901067118684104   Update date: Feb. 01, 2024

HAMADA Kozo

ハマダ コウゾウ | HAMADA Kozo
Affiliation and department：
Xian Jiaotong Liverpool University (XJTLU) School of Science

About Xian Jiaotong Liverpool University (XJTLU) School of Science


Job title： Associate Professor (PI)
Other affiliations (2)：
Homepage URL  (1)： https://www.xjtlu.edu.cn/en/study/departments/school-of-science/biological-sciences/department-staff/academic-staff
Research keywords  (21)： IP3 receptor ,  Dimentia ,  signal transduction ,  receptor ,  Aging ,  tau ,  Alzheimer's disease ,  structural biology ,  electron microscopy ,  X-ray crystallography ,  autophagy ,  calcium signaling ,  Huntington disease ,  polyglutamine disease ,  neurodegenerative disease ,  transglutaminase ,  endoplasmic reticulum ,  ion channel ,  neurochemistry ,  biomedical chemistry ,  biochemistry
Research theme for competitive and other funds  (6)：
  • 2021 - 2024 Role of Ca2+ signaling at ER microdomains in dementia
  • 2015 - 2021 小胞体カルシウムチャネルのアロステリック制御異常による認知症の発症機序
  • 2017 - 2019 タンパク質老化と毒性機序における小胞体カルシウムの役割
  • 2015 - 2018 光刺激反応系を用いたCa2+依存的膵外分泌機構の解明
  • 2015 - 2017 タウタンパク質老化と毒性機序における小胞体カルシウムの役割
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Papers (31)：
  • Lavik AR, McColl KS, Lemos FO, Kerkhofs M, Zhong F, Harr M, Schlatzer D, Hamada K, Mikoshiba K, Crea F, et al. A non-canonical role for pyruvate kinase M2 as a functional modulator of Ca2+ signalling through IP3 receptors. Biochim Biophys Acta Mol Cell Res. 2022. 1869. 4. 119206
  • Rosa N, Ivanova H, Wagner LE, Kale J, La Rovere R, Welkenhuyzen K, Louros N, Karamanou S, Shabardina V, Lemmens I, et al. Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis. Cell Death Differ. 2022. 29. 4. 788-805
  • Yuki Kanda, Ryosuke Satoh, Teruaki Takasaki, Naofumi Tomimoto, Kiko Tsuchiya, Chun An Tsai, Taemi Tanaka, Shu Kyomoto, Kozo Hamada, Toshinobu Fujiwara, et al. Sequestration of the PKC ortholog Pck2 in stress granules as a feedback mechanism of MAPK signaling in fission yeast. J Cell Sci. 2021. 134. 2
  • Hamada K, Mikoshiba K. IP3 Receptor Plasticity Underlying Diverse Functions. Annual Review of Physiology. 2020. 82. 151-176
  • Lili Yue, Liuqing Wang, Yangchun Du, Wei Zhang, Kozo Hamada, Yoshifumi Matsumoto, Xi Jin, Yandong Zhou, Katsuhiko Mikoshiba, Donald L Gill, et al. Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells. Cells. 2020. 9. 2
ｍore...
MISC (4)：
Patents (3)：
Books (4)：
  • Gating mechanism of calcium channels in the endoplasmic reticulum
    NTS inc 2018
  • New evidence for gating mechanism of the IP3 receptor
    Jikken Igaku 2018
  • 小胞体ストレス, レドックス制御, カルシウムシグナルと神経細胞死
    実験医学 2012
  • イノシトール三リン酸受容体の構造と機能制御
    実験医学 2003
Lectures and oral presentations  (20)：
  • IP3-Mediated Gating Mechanism of IP3 Receptor
    (Gordon Research Conference (US) 2018)
  • Allosteric Gating Mechanism of IP3 Receptors Revealed by Mutagenesis and X-ray Crystallography, and Its Implications for Diseases
    (Consortium of Biological Sciences 2017 2017)
  • Gating mechanism of the IP3 receptor revealed by mutagenesis and X-ray crystallography
    (2017)
  • Gating Mechanism of IP3 Receptors
    (Osaka University, IPR Seminar 2017)
  • Gating Mechanism of IP3 Receptors Revealed by Mutagenesis and X-Ray Crystallography (Late-Breaking Topics)
    (Gordon Research Conference (Italy) 2017)
ｍore...
Education (4)：
  • 1993 - 1998 The University of Tokyo Institute of International Health Department of Biomedical Chemistry
  • 1991 - 1993 The University of Tokyo School of Health Science Department of Biochemistry and Nutrition
  • 1989 - 1991 The University of Tokyo School of Health Science Department of Biochemistry and Nutrition
  • 1987 - 1989 The University of Tokyo Natural Science II
Professional career (3)：
  • Ph. D. (The University of Tokyo)
  • M. Sc. (The University of Tokyo)
  • B. S. (The University of Tokyo)
Work history (7)：
  • 2023/07 - 現在 Xian Jiaotong Liverpool University (XJTLU) Department of Biological Sciences, School of Science Associate Professor, Principal Investigator (PI)
  • 2019/04 - 現在 Toho univiersity Faculty of science Visiting researcher
  • 2018/11 - 現在 Kindai Unversity Faculty of pharmacy Researcher
  • 2019/04 - 2023/06 ShanghaiTech university SIAIS Associate Professor
  • 2010 - 2018/10 RIKEN BSI Researcher
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Association Membership(s) (2)：
THE JAPANESE BIOCHEMICAL SOCIETY ,  THE JAPANESE SOCIETY FOR NEUROCHEMISTRY
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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