Rchr
J-GLOBAL ID：200901067151877937
Update date: Oct. 30, 2024
Taniguchi Yosuke
タニグチ ヨウスケ | Taniguchi Yosuke
Affiliation and department：
Job title：
professor
Homepage URL (1)：
https://sites.google.com/view/taniguchi-lab/
Research field (1)：
Pharmaceuticals - chemistry and drug development
Research keywords (5)：
WNA
, nucleoside analogue
, antigene
, Triplex
, triplex
Research theme for competitive and other funds (16)：
- 2023 - 2027 3本鎖DNA形成を基軸とした人工核酸の開発と遺伝子発現コントロール技術への新展開
- 2021 - 2027 非天然核酸による損傷DNAシーケンシング技術の創成
- 2020 - 2024 脳疾患部位を標的とする先端的核酸デリバリー技術の確立と脳疾患治療への挑戦
- 2019 - 2023 Development of artificial nucleoside analogues for the duplex DNA recognition, and antigene oligonucleotides
- 2017 - 2020 Development of novel gene detection method using artificial nucleic acid capable of recognizing damaged bases
- 2016 - 2019 Examination of oligonucleotide therapeutics based on the triplex DNA formation by artificial oligonucleotide
- 2015 - 2018 Chemically reactive oligonucleotides for site-specific modification of RNA and artificial RNA editing
- 2014 - 2017 Development of CpG island binding molecule based on artificial dinucleotide
- 2012 - 2016 Development of antigene strategy by triplex forming oligonucleotides having artificial nucleoside analogues
- 2012 - 2014 Development of the recognition molecule for 8-oxo-rG in RNA
- 2008 - 2009 Development of the nucleoside analogs to harmonize with in vivo molecular function
- 2007 - 2008 タンパク質との機能融合を目指したゲノム標的機能性人工核酸の開発
- 2005 - 2008 Development of Genome-Targeting Molecules with Ability of Chemical Reactivity and Application to Intelligent Nano-Medicine
- 2005 - 2006 3本鎖認識コードの拡張を目的とする人工ヌクレオシドの創製
- 3本鎖DNA形成を可能にする人工核酸の開発
- Synthesis of the W-shaped nucleoside analogues
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Papers (97)：
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Hirotaka Murase, Jeongsu Lee, Norihiro Togo, Yosuke Taniguchi, Shigeki Sasaki. The selective chemical modification of the 6-amino group of adenosine of the premature termination codon induces readthrough to produce full-length peptide in the reconstituted E. Coli translation system. Bioorganic & Medicinal Chemistry. 2024. 111. 117868-117868
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Lei Wang, Dezhi Wang, Wenzhuo Lei, Tiantian Sun, Bei Gu, Han Dong, Yosuke Taniguchi, Yichang Liu, Yong Ling. Trigonometric Bundling Disulfide Unit Starship Synergizes More Effectively to Promote Cellular Uptake. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024. 25. 14
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Kosuke Tomimatsu, Takeru Fujii, Ryoma Bise, Kazufumi Hosoda, Yosuke Taniguchi, Hiroshi Ochiai, Hiroaki Ohishi, Kanta Ando, Ryoma Minami, Kaori Tanaka, et al. Precise immunofluorescence canceling for highly multiplexed imaging to capture specific cell states. Nature Communications. 2024. 15. 1
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Takato Sakurada, Yuta Chikada, Ryo Miyahara, Yosuke Taniguchi. Recognition of 8-Oxo-2′-deoxyguanosine in DNA Using the Triphosphate of 2′-Deoxycytidine Connecting the 1,3-Diazaphenoxazine Unit, dCdapTP. MOLECULES. 2024. 29. 10
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Akihiro Ito, Lei Wang, Ryotaro Notomi, Shigeki Sasaki, Yosuke Taniguchi. Development of an Artificial Nucleic Acid Skeleton Allowing for Unnatural-Type Triplex DNA Formation with Duplex DNA Having a TA Inversion Site. CHEMICAL & PHARMACEUTICAL BULLETIN. 2024. 72. 1. 16-20
ｍore...
MISC (2)：
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Y Taniguchi, A Nakamura, Y Senko, F Nagatsugi, S Sasaki. Effects of halogenated WNA derivatives on sequence dependency for expansion of recognition sequences in non-natural-type triplexes. JOURNAL OF ORGANIC CHEMISTRY. 2006. 71. 5. 2115-2122
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Y Taniguchi, S Sasaki. Development of novel artificial nucleosides for expansion of triplex-recognition codes. JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN. 2004. 62. 10. 1026-1037
Professional career (1)：
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