Research theme for competitive and other funds (21):
2013 - 2018 Study on nanochemistry in latest nanofabrication materials using quantum beams
2011 - 2013 Conformational change of DNA bound to transcription factor response to environmental change
2010 - 2012 Study on nanoscale chemical reactions and reaction sites using quantum beams
2007 - 2008 Mechanism in Regulation of Transcription Factor containing Fe-S Clusters Sensing Oxidative Stress
2000 - 2004 短寿命活性種をシグナルとするセンサー蛋白質の構造と機能
2002 - 2003 Mechanism of Redox-linked Proton Pumping in Terminal Enzyme of Cellular Respiration Studied by Pulse Radiolysis
1999 - 2001 Study on primary processes of radiation chemistry in aqueous solutions using femtosecond quantum multibeams
2000 - 遺伝子の放射線損傷機構
1996 - 1999 金属蛋白質による情報変換
1996 - 1996 Lipid Peroxidationにおける一酸化窒素の生理的役割
1995 - 1995 Peroxynitriteの作用機序の分子機構
1992 - 1992 パルスラジオリシス法による酸素添加酵素における反応中間体構造の解明
1992 - 1992 システイニルロイコトリエン輸送タンパク質の性質
1991 - 1991 パルスラジオリシス法による酸素添加酵素による反応中間体構造の解明
1991 - 1991 肝臓形質膜におけるATPに依存したグルタチオン抱合体輸送体の性質
活性酸素シグナルによる生体制御
生体における電子移動の機構
一酸化窒素の生体における動的解析
Biological Regulation by Active Oxygen Species
Mechanism of Electron transfer in biological system
Kinetic behavior of NO in biological system
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Papers (115):
Kazuo Kobayashi, Yuko Tsutsui Ito, Yuri Kasu, Masaki Horitani, Takahiro Kozawa. Intramolecular electron transfer from biopterin to FeII-O2 complex in nitric oxide synthases occurs at very different rates between bacterial and mammalian enzymes: Direct observation of a catalytically active intermediate. Journal of inorganic biochemistry. 2023. 238. 112035-112035
Kazuo Kobayashi, Jotaro Igarashi, Takahiro Kozawa. Interdomain electron transfer in flavohaemoglobin from Candida norvegensis with antibiotic azole compounds. FEBS LETTERS. 2022
Toshinori Oozeki, Tadashi Nakai, Kazuki Kozakai, Kazuki Okamoto, Shun’ichi Kuroda, Kazuo Kobayashi, Katsuyuki Tanizawa, Toshihide Okajima. Functional and structural characterization of a flavoprotein monooxygenase essential for biogenesis of tryptophylquinone cofactor. Nature Communications. 2021. 12. 1
Kazuo Kobayashi, JeeEun Kim, Yohta Fukuda, Takahiro Kozawa, Tsuyoshi Inoue. Fast autooxidation of a bis-histidyl-ligated globin from the anhydrobiotic tardigrade,Ramazzottius varieornatus, by molecular oxygen. The Journal of Biochemistry. 2021