Itakura Mitsuo

• 2012 - 2015 Genetic identification and functional analysis in Japanese families with a short stature
• 2011 - 2012 日本人小児低身長症の疾患関連遺伝子同定と分子機構の解明
• 2010 - 2012 Identification of genetic factor for type 1 diabetes mellitus
• 2007 - 2008 Functional analysis of theENDOGL1 gene as a candidate disease susceptibility gene for T2D by rentivirus vector
• 2007 - 2008 Fine mapping of candidate regions identtfied by QTL analysis and functiohal analysis of candidate genes located within the QTL region
2005 - 2006 Mapping of susceptibility genes to diabetes by high fat diet following QTL analysis of diabetic db mice
2005 - 2006 The strategies for overcoming the graft dysfunction after liver transplantation using small-for-size graft
2004 - 2006 Identification of type 2 diabetes mellitus susceptibility candidate genes in loci detected by QTL analysis of diabetic db mice,
2004 - 2005 顎骨骨幹異形成症の原因遺伝子の同定と機能解析
2004 - 2005 Evaluation of pharmacotherapy with reference to QOL and the analysis of therapeutic drug response.
2003 - 2004 上皮間葉相互作用破綻による口蓋裂発症機序の解明
2003 - 2004 関節リウマチの疾患感受性遺伝子の同定
2001 - 2003 Identification of susceptibility gene of diabetes mellitus by QTL analysis in the genetic modified mice
2000 - 2003 The research for the genetic factors of rheumatoid arthritis using the methods applying the polymorphism in microsatellites and the single nucleotide polymorphism
2001 - 2002 The induction of the immunotolerance in islet transplantation model using transgenic NOD mice in which TGF-β1 is expressed in pancreatic α cell
2001 - 2002 Analysis of Pancreatic B-Cell Development and an Animal Model of Regeneration Therapy for Diabetes Mellitus Using Transgenic Mice
2000 - 2002 Molecular basic research for obtaining genes specifying characteristics of pancreatic α and β cells.
1999 - 2000 Immunosuppressive role of TGF-β1 against autoimmune destruction of islet β cells and a basic study on islet β cells of NOD-RGP-TGF-β1 Tg
1999 - 2000 Experimental studies on circulatory disturbances in the spinal cord after traumatic spinal cord injury.
1998 - 2000 Analysis of Islet Development Using Transgenic Mice
1998 - 1999 候補遺伝子アプローチ・連鎖解析・罹患同胞対解析を用いる痛風の病因遺伝子の同定
1997 - 1999 Identification of susceptibility gene of diabetes mellitus y QTL analysis in the genetic modified mice.
1996 - 1998 Role of growth factors and morphogens in cell differentiation
1996 - 1997 膵臓のランゲルハンス島のβ細胞の形作りに関わるサイトカインの発生工学的解析
1995 - 1996 Analysis of Diabetic Complications Using Transgenic Mice
1995 - 1996 Isolation of genes related to malignant transformation of thyroid tumors and gene therapy for undifferentiated carcinoma of the thyroid
1994 - 1995 Molecular Biology of B-Cells of Pancreatic Islets of Langerhans : Basic Study to develop Gene Therapy for Diabetes
1993 - 1994 Analysis of Immunological Destruction Mechanism of Pancreatic Islet B Cells Using a Transgenic Mouse Model
1992 - 1994 Development of Gene Therapy for Type I Diabetes Using Cytokine Gene and Pancreatic Islet B Cell-Specific Lymphocytes
1992 - 1993 Analysis genetic changes in human endocrine tumors
1991 - 1992 Molecular Analysis of a Glucose-concentration sensing system which Regulates Insulin Gene Expression
1989 - 1991 Development of the Methods for Regulated Expression of Transduced Gene in Transkaryotic Gene Therapy
1988 - 1989 Molecular Biological Study on Rate-limiting Enzyme DNA of de novo Purine Synthesis by Gene Transfer and Controllable Expression
疾患モデル動物とヒトを対象とする多遺伝子性疾患の疾患感受性 遺伝子の同定
Identification of disease-susceptibility genes of polygenic diseases using animal models and human subjects

• Parvaneh Keshavarz, Hiroshi Inoue, Naoto Nakamura, Toshikazu Yoshikawa, Toshihito Tanahashi, Mitsuo Itakura. Single nucleotide polymorphisms in genes encoding LKB1 (STK11), TORC2 (CRTC2) and AMPK α2-subunit (PRKAA2) and risk of type 2 diabetes. Molecular Genetics and Metabolism. 2008. 93. 2. 200-209
• Shusuke Numata, Shu ichi Ueno, Jun ichi Iga, Masahito Nakataki, Toshihito Tanahashi, Mitsuo Itakura, Akira Sano, Kazutaka Ohi, Ryota Hashimoto, Masatoshi Takeda, et al. No association between the NDE1 gene and schizophrenia in the Japanese population. Schizophrenia Research. 2008. 99. 1-3. 367-369
• Katsutoshi Miyatake, Hiroshi Inoue, Kahoko Hashimoto, Hiroshi Takaku, Yoichiro Takata, Shunji Nakano, Natsuo Yasui, Mitsuo Itakura. PKC412 (CGP41251) modulates the proliferation and lipopolysaccharide-induced inflammatory responses of RAW 264.7 macrophages. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2007. 360. 1. 115-121
• Dai Osabe, Toshihito Tanahashi, Kyoko Nomura, Shuichi Shinohara, Naoto Nakamura, Toshikazu Yoshikawa, Hiroshi Shiota, Parvaneh Keshavarz, Yuka Yamaguchi, Kiyoshi Kunika, et al. Evaluation of sample size effect on the identification of haplotype blocks. BMC BIOINFORMATICS. 2007. 8. 200
• Parvaneh Keshavarz, Hiroshi Inoue, Yukiko Sakamoto, Kiyoshi Kunika, Toshihito Tanahashi, Naoto Nakamura, Toshikazu Yoshikawa, Natsuo Yasui, Hiroshi Shiota, Mitsuo Itakura. Erratum: No evidence for association of the ENPP1 (PC-1) K121Q variant with risk of type 2 diabetes in a Japanese population (Journal of Human Genetics (2006) 51 (559-566) DOI: http://dx.doi.org/10.1007/s10038-006-0399-0). Journal of Human Genetics. 2006. 51. 7. 644

ｍore...

• Makoto Kinoshita, Shusuke Numata, Atsushi Tajima, Kazutaka Ohi, Ryota Hashimoto, Shinji Shimodera, Issei Imoto, Mitsuo Itakura, Masatoshi Takeda, Tetsuro Ohmori. Meta-analysis of association studies between DISC1 missense variants and schizophrenia in the Japanese population. Schizophrenia Research. 2012. 141. 2-3. 271-273
• Hiroshi Inoue, Yukiko Sakamoto, Mitsuo Itakura, Tsutomu Ogata, Kenji Fujieda. Identification and functional analysis of novel human growth hormone secretagogue receptor type la variants in Japanese subjects with short stature. ENDOCRINE JOURNAL. 2010. 57. S604-S604
• Masahito Nakataki, Shusuke Numata, Jun-Ichi Iga, Shin'Ya Tayoshi, Sumiko Tayoshi-Shibuya, Hongwei Song, Toshihito Tanahashi, Mitsuo Itakura, Shu-Ichi Ueno, Tetsuro Ohmori. No association between Rho-associated coiled-coil forming protein serine/threonine kinasel gene and schizophrenia in the Japanese population. Psychiatric Genetics. 2009. 19. 3. 162
• Yoichiro Takata, Hiroshi Inoue, Aya Sato, Kazue Tsugawa, Katsutoshi Miyatake, Daisuke Hamada, Fumio Shinomiya, Shunji Nakano, Natsuo Yasui, Toshihito Tanahashi, et al. Replication of reported genetic associations of PADI4, FCRL3, SLC22A4 and RUNX1 genes with rheumatoid arthritis: results of an independent Japanese population and evidence from meta-analysis of East Asian studies. JOURNAL OF HUMAN GENETICS. 2008. 53. 2. 163-173
• Eiji Kudo, Mitsuo Itakura. Uromodulin mutation and hyperuricemia. Nippon rinsho. Japanese journal of clinical medicine. 2008. 66. 4. 778-783

ｍore...

• 「ゲノムと疾患」、多因子疾患の診断および研究法
  南山堂 2004
• 「新臨床内科学、コンパクト版、第3版」、VI.先天性代謝疾患
  医学書院 2003
• ゲノム研究の最先端、ポストゲノム時代の内視鏡学
  中山書店 2002
• ポストゲノム時代の遺伝統計学、パラメトリック連鎖解析によるFJHN遺伝子領域の同定
  羊土社 2001
• 「新臨床内科学、コンパクト版、第2版」、先天性(遺伝性)代謝疾患、882-、 膵嚢胞性線維症、885- 、 Marfan症候群、 887- 、Ehlers-Danlos症、 -
  医学書院 2001

ｍore...

• The University of Tokyo Faculty of Medicine School of Medicine
• School of Medicine and Faculty of Medicine, University of Tokyo

• Doctor of Medicine

• 1998 - :徳島大学教授ゲノム機能研究センター遺伝情報分野
• 1998 - Director and Professor of Division of Genetic Information,
• 1990 - :徳島大学医学部客員教授臨床分子栄養学(大塚)講座
• 1990 - Professor of Otsuka Department of Clinical and
• 1985 - :文部省在外研究員(アメリカ合衆国Duke大学
1985 - Visiting Professor at Division of Metabolism,
1980 - :筑波大学講師臨床医学系(代謝内分泌内科)
1980 - :アメリカ合衆国Duke大学Medical Centerにて
1980 - Assistant Professor of Division of Endocrinology
1980 - Research Associate at Duke University Medical Center
1976 - :アメリカ合衆国Duke大学Medical Centerにて
1976 - Postdoctoral Research and Clinical Fellow at Duke
Medical Center Visiting Professor)
Research Associate
Postdoctoral Research and Clinical Fellow
Institute for Genome Research, the University of Tokuhsima
of Tokushima
Molecular Nutrition, School of Medicine, The University
(supported by the Ministry of Education and Welfare of Japan)
Endocrinology, and Genetics, Duke University Medical Center.
The University of Tsukuba
and Metabolism, Institute of Clinical Medicine,
University Medical Center

• 2002年 日本痛風核酸代謝学会賞
• 治療法開発のための基礎研究"代表研究者
• 対する免疫調節性サイトカインの役割:1型糖尿病に対する遺伝子
• "自己免疫性膵島炎と糖尿病に
• 1994-1995 若年性糖尿病基金 研究賞
Principal Investigator
developing gene therapy against type I diabetes",
autoimmune Insulitis and diabetes : The basic study for
Award, "Role of Immuno-modulatory cytokines for
1994-1995 Juvenile Diabetes Foundation Research Grant

日本臨床分子医学会 ,  日本免疫学会 ,  日本分子生物学会 ,  日本内分泌学会 ,  日本内科学会 ,  日本糖尿病学会 ,  日本生化学会 ,  日本癌学会 ,  日本遺伝子治療学会 ,  日本リウマチ学会 ,  日本・痛風・核酸代謝学会 ,  遺伝子診断学会 ,  The Molecular Biology Society of Japan ,  The Japanese Society of Internal Medicine ,  The Japanese Society of Gene Diagnosis and Therapy ,  The Japanese Cancer Association ,  The Japanese Biochemical Society ,  The Japan Society of Gene Therapy ,  The Japan Rheumatism Association ,  The Japan Endocrine Society ,  Japanese Society of Molecular Medicine ,  Japanese Society of Gout and Nucleic Acid Metabolism ,  Japanese Society for Immunology ,  Japan Diabetes Society