Rchr

J-GLOBAL ID：200901067679914273 Update date: Oct. 16, 2024

HIROSHI NAKAGAWA

ナカガワヒロシ | HIROSHI NAKAGAWA

Affiliation and department：
Job title： Assistant Professor
Homepage URL (1)： https://www3.chubu.ac.jp/faculty/nakagawa_hiroshi/

Research field (5)： Environmental and pharmaceutical development resources , Tumor biology , Pharmaceuticals - health and biochemistry , Nutrition and health science , Cell biology

Research keywords (8)： individual differences , Multidrug resistance , Natural products , Cholesteatoma , Bone and muscles , SNPs , ABC transporter , 抗生物質一般

Research theme for competitive and other funds (24)：

2022 - 2025 可逆的V-ATPase阻害機構の解明に向けた環状ペプチドプローブの創製と応用
2021 - 2024 Earwax determination gene ABCC11 polymorphism related to flora in the ear wax and risk of developing middle ear cholesteatoma
2020 - 2023 Study for the mechanism of functional expression and dysfunction of membrane proteins through direct observations of single molecular fluctuation
2019 - 2022 ABC輸送体遺伝子欠損動物を基盤に展開する「運動器の成長・老化メカニズムの解析」
2018 - 2021 外耳・中耳の耳内環境pH変化と中耳真珠腫発生および進行リスク

2018 - 2021 新規がん温熱療法におけるオープンイノベーション研究

2016 - 2019 遺伝子欠損動物を基盤に展開する「栄養因子・ABC輸送体・運動器の相互連関解析」

2015 - 2019 ステロール代謝の分子栄養科学的制御と動脈硬化症

2017 - 2018 日本人に高頻度で認められる「ABC輸送体の一塩基多型」と「がんの抗がん剤耐性」との相関評価

2015 - 2018 外耳・中耳に発現するABC輸送体と組織環境に伴う中耳真珠腫の発症・進行リスク

2016 - 2017 がんの抗がん剤耐性に関わる潜在的ABC輸送体の探索と抗がん剤感受性の個人差解析

2015 - 2017 乳腺内物質動態制御に着目した新規乳がんリスク因子の実験的検証と関連分子機構の解明

2014 - 2017 骨吸収抑制作用と骨形成促進作用を併せ持つ天然物を起点にした骨代謝の理解と創薬

2015 - 2016 細胞の抗がん剤耐性に影響を及ぼす一塩基多型の臨床的意義の検証

2012 - 2015 破骨細胞の発生・機能を基点にしたABC輸送体と骨代謝との包括的相互連関解析

2014 - 2014 破骨細胞の極性発現機構を制御する化合物の構造情報を起点にした創薬基盤の構築

2013 - 2014 がんの薬剤感受性を制御する一塩基多型の同定

2013 - 2014 ケミカルバイオロジー的手法を用いたCD98依存性細胞融合機構の解析

2012 - 2013 骨粗鬆症治療薬候補化合物デストラキシンEを量産する基盤技術の確立

2010 - 2012 破骨細胞と骨組織におけるAbca5の発現と生理機能の解析

2007 - 2010 -

2009 - 2010 世界最速SNP診断装置の開発

2007 - 2009 ヒトABCトランスポーターの遺伝子多型を認識するタンパク品質管理機構の解明

2006 - 2009 Chemical biology targeting the brain : Molecular design of anticancer agents that efficiently attack brain tumors

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Papers (71)：

Satoshi Hara, Takeshi Kusunoki, Hiroshi Nakagawa, Kazusaku Kamiya, Yu Toyoda, Yusuke Takata, Takashi Anzai, Masayuki Furukawa, Hiroko Okada, Takumi Nakayama, et al. Impact of Reduced Acidic Earwax pH and Earwax-Determinant Genotypes in Acquired Middle Ear Cholesteatoma. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 2024
Hiroshi Sato, Hayato Murase, Yoshitaka Ishida, Haruki Sugiyama, Hidehiro Uekusa, Hiroshi Nakagawa, Masahito Yoshida, Takayuki Doi. Destruxin E backbone modification effects on osteoclast Morphology: Synthesis and SAR study of N-Desmethyl and N-Methyl analogs. Bioorganic & medicinal chemistry. 2024. 108. 117777-117777
Fitriani Jati Rahmania, Yi-Shou Huang, Yitayal Admassu Workie, Toyoko Imae, Anna Kondo, Yukiko Miki, Ritsuko Imai, Takashi Nagai, Hiroshi Nakagawa, Noriyasu Kawai, et al. Preparation of Functional Nanoparticles-Loaded Magnetic Carbon Nanohorn Nanocomposites towards Composite Treatment. Nanomaterials (Basel, Switzerland). 2023. 13. 5
Masahito Yoshida, Hiroshi Nakagawa, Takayuki Doi. Synthetic studies for destruxins and biological evaluation for osteoclast-like multinucleated cells: a review. The Journal of antibiotics. 2022. 75. 8. 420-431
Satoru Hagiwara, Naoshi Nishida, Hiroshi Ida, Kazuomi Ueshima, Yasunori Minami, Masahiro Takita, Tomoko Aoki, Masahiro Morita, Hirokazu Chishina, Yoriaki Komeda, et al. Role of phlebotomy in the treatment of liver damage related to erythropoietic porphyria. Scientific reports. 2022. 12. 1. 6100-6100

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MISC (10)：

井上裕貴, 斎藤健一, 新井美砂, 大森丈彰, 小野塚真理, 近藤正巳, 佐野和美, 花田和彦, 中川大, 池上洋二. 第二世代BCR-ABLチロシンキナーゼ阻害薬の輸送に対するABCG2の遺伝子多型の影響. 日本薬学会年会要旨集. 2019. 139年会. 4. 106-106
井上裕貴, 斎藤健一, 関根清香, 柳下夏美, 深沼舞衣, 小野塚真理, 佐野和美, 花田和彦, 中川大, 池上洋二. ABCG2の遺伝子変異が第二世代BCR-ABLチロシンキナーゼ阻害剤の輸送に及ぼす影響. 日本薬学会年会要旨集. 2018. 138年会. 4. 96-96
Kenkichi Takahashi, Naokado Ikeda, Naosuke Nonoguchi, Yoshinaga Kajimoto, Shin-Ichi Miyatake, Yuichiro Hagiya, Shun-Ichiro Ogura, Hiroshi Nakagawa, Toshihisa Ishikawa, Toshihiko Kuroiwa. Enhanced expression of coproporphyrinogen oxidase in malignant brain tumors: CPOX expression and 5-ALA-nduced fluorescence (Retraction of vol 13, pg 1234, 2011). NEURO-ONCOLOGY. 2013. 15. 7. 969-969
中川大. 遺伝子を構成する分子1つの違いから個人の違いを理解する. ANTENNA. 2013. 118. 16-16
豊田優, Aw Wanping, Lezhava Alexander, 中川大, 林崎良英, 石川智久. 【トランスポートソーム生体膜輸送機構の全体像に迫る基礎、臨床、創薬応用研究の最新成果】薬物動態におけるトランスポーター研究の新展開ヒトABCトランスポーターのファーマコゲノミクス迅速SNP検出法の開発. 遺伝子医学MOOK. 2011. 19. 160-166

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Patents (2)：

細胞融合阻害剤及びその用途
ABCタンパク質が輸送する基質のスクリーニング方法、及びABCタンパク質の輸送活性の測定法

Books (11)：

茶の事典, 抗骨粗鬆症
朝倉書店 2017
Drugs affecting epigenetics of ABC transporters for drug resistance. Thomas E., editor, Resistance to Targeted Anti-Cancer Therapeutics Vol. 4, Resistance to Targeted ABC Transporters in Cancer
Springer International Publishing Switzerland 2015
腋臭症・多汗症治療実践マニュアル, ABCC11遺伝子の機能
全日本病院出版会 2011
機能性食品素材の骨と軟骨への応用, カテキン
シーエムシー出版 2011
遺伝子医学MOOK, 小胞体におけるABCトランスポーターの品質管理 -ユビキチン-プロテアソーム経路による新生ABCG2蛋白質の除去-
株式会社メディカルドゥ 2011

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Lectures and oral presentations (2)：

一塩基多型がもたらすヒトABC輸送体ABCG2の機能・安定性の変化
(近畿大学医学会学術講演会 2014)
ABC輸送体ABCG2とその一塩基多型の影響
(桐蔭横浜大学大学院セミナー 2014)

Education (5)：

2001 - 2004 Tokyo University of Agriculture and Technology Faculty of Agriculture the laboratory of Prof. Keiji Hasumi, Department of Applied Biological Science
2001 - 2004 Tokyo Institute of Technology Graduate School of Bioscience and Biotechnology Department of Bioengineering
- 2004 Tokyo Institute of Technology Graduate School, Division of Life Science and Engineering
1999 - 2001 Tokyo Institute of Technology Graduate School of Bioscience and Biotechnology Department of Biotechnology
1995 - 1999 Tokyo Institute of Technology School of Bioscience and Biotechnology Department of Bioengineering

Professional career (1)：

Doctor of Engineering (Tokyo Institute of Technology)

Work history (26)：

2019/04 - 現在 Chubu University Department of Applied Biological Chemistry, College of Bioscience and Biotechnology Associate Professor
2023/08 - 2023/09 University Hospital of Heidelberg The laboratory of Dr. Jochen Heß at Experimental Head and Neck Oncology, Department of Otolaryngology, Head and Neck Surgery Visiting Scientist
2023/02 - 2023/03 University Hospital of Heidelberg The laboratory of Dr. Jochen Heß at Experimental Head and Neck Oncology, Department of Otolaryngology, Head and Neck Surgery Visiting Scientist
2022/08 - 2022/09 University Hosptal of Heidelberg The laboratory of Dr. Jochen Heß at Experimental Head and Neck Oncology, Department of Otolaryngology, Head and Neck Surgery Visiting Scientist
2022/04 - 2022/05 University Hospital of Heidelberg The laboratory of Dr. Jochen Heß at Experimental Head and Neck Oncology, Department of Otolaryngology, Head and Neck Surgery Visiting Scientist

2022/02 - 2022/03 University Hosptal of Heidelberg The laboratory of Dr. Jochen Heß at Experimental Head and Neck Oncology, Department of Otolaryngology, Head and Neck Surgery Visiting Scientist

2020/03 - 2020/03 University Hospital Heidelberg The laboratory of Dr. Jochen Heß at Experimental Head and Neck Oncology, Department of Otolaryngology, Head and Neck Surgery Visiting Scientist

2019/08 - 2019/09 Heidelberg University Hospital The laboratory of Dr. Jochen Heß at Experimental Head and Neck Oncology, Department of Otolaryngology, Head and Neck Surgery

2019/03 - 2019/03 Heidelberg University Hospital The laboratory of Dr. Jochen Heß at Experimental Head and Neck Oncology, Department of Otolaryngology, Head and Neck Surgery

2018/04 - 2019/03 Chubu University Department of Food and Nutritional Sciences, College of Bioscience and Biotechnology Associate Professor

2018/07 - 2018/08 Heidelberg University Hospital The laboratory of Dr. Jochen Heß at Experimental Head and Neck Oncology, Department of Otolaryngology, Head and Neck Surgery Visiting scientist

2018/03 - 2018/03 Heidelberg University Hospital The laboratory of Dr. Jochen Heß at Experimental Head and Neck Oncology, Department of Otolaryngology, Head and Neck Surgery Visiting scientist

2017/12 - 2018/03 中部大学応用生物学部食品栄養科学科 (応用生物化学科兼任) 講師

2010/09 - 2017/11 Chubu University Department of Applied Biological Chemistry, College of Bioscience and Biotechnology Lecturer

2017/08 - 2017/09 Heidelberg University Hospital The laboratory of Dr. Jochen Heß at Experimental Head and Neck Oncology, Department of Otolaryngology, Head and Neck Surgery Visiting scientist

2017/02 - 2017/03 Heidelberg University Hospital The laboratory of Dr. Jochen Heß at Experimental Head and Neck Oncology, Department of Otolaryngology, Head and Neck Surgery Visiting scientist

2016/08 - 2016/09 Heidelberg University Hospital The laboratory of Dr. Jochen Heß at Experimental Head and Neck Oncology, Department of Otolaryngology, Head and Neck Surgery Visiting scientist

2015/09 - 2015/09 Heidelberg University Hospital The laboratory of Dr. Jochen Heß at Experimental Head and Neck Oncology, Department of Otolaryngology, Head and Neck Surgery Visiting scientist

2014/08 - 2014/09 Heidelberg University Hospital The laboratory of Dr. Jochen Heß at Experimental Head and Neck Oncology, Department of Otolaryngology, Head and Neck Surgery Visiting scientist

2008/04 - 2010/08 Tokyo Institute of Technology Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology Assistant Professor

2010/01 - 2010/03 The Japanese Society for the Promotion of Science (JSPS) International Training Program (ITP) fellow

2010/01 - 2010/03 University of Heidelberg The laboratory of Prof. Gert Fricker at Institute of Pharmacy and Molecular Biotechnology, Department of Pharmaceutical Technology Visiting scientist

2008/07 - 2008/10 The Japanese Society for the Promotion of Science (JSPS) International Training Program (ITP) fellow

2008/07 - 2008/10 University of Heidelberg The laboratory of Prof. Gert Fricker at Institute of Pharmacy and Molecular Biotechnology, Department of Pharmaceutical Technology Visiting scientist

2004/10 - 2008/03 Tokyo Institute of Technology Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology Assistant Professor

2004/04 - 2004/09 Tokyo Institute of Technology the laboratory of Prof. Toshihisa Ishikawa at Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology Postdoctoral Researcher

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Committee career (9)：

2021 - 現在 Phytomedicine Plus Editorial Board member
2020 - 現在 Biomolecules Editorial Board member
2017 - 現在 Journal of Pharmacy and Pharmaceutical Research Editorial Board member
2017 - 現在 Medical Research and Innovations Editorial Board member
2008 - 現在トランスポーター研究会幹事

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Awards (1)：

2010/03 - FEBS-ABC2010 - 3rd FEBS Special Meeting on ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases. Special ABC2010 Poster Recognition Award The impacts of posttranslational modifications and non-synonymous SNPs on the protein stability of human ABC transporter ABCG2 protein in culture cells.

Association Membership(s) (12)：

THE JAPANESE SOCIETY OF PHARMACOGNOSY , THE PHARMACEUTICAL SOCIETY OF JAPAN , CHEM-BIO INFORMATICS SOCIETY , JAPANESE SOCIETY FOR CHEMICAL BIOLOGY , THE JAPANESE CANCER ASSOCIATION , JAPANESE ASSOCIATION FOR ANIMAL CELL TECHNOLOGY , THE JAPANESE BIOCHEMICAL SOCIETY , トランスポーター研究会 , 日本骨代謝学会 , 日本分子生物学会 , 日本農芸化学会 , Japan Transporter Research Association

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