Rchr
J-GLOBAL ID:200901067961164473   Update date: Oct. 25, 2021

Fujita Kaori

フジタ カオリ | Fujita Kaori
Affiliation and department:
Research field  (2): Cell biology ,  Molecular biology
Research keywords  (8): Aging ,  Cellular Senescence ,  p53 isoform ,  p53 ,  細胞生物学 ,  分子生物学 ,  cell biology ,  molecular biology
Research theme for competitive and other funds  (3):
  • 2018 - 2022 抗老化因子Δ133p53による軟骨細胞への分化誘導と増殖の分子機構解明とその応用
  • 2013 - 2017 細胞老化を克服した軟骨細胞分化誘導/維持メカニズムの解析
  • 2014 - 2016 二次元培養下での脱分化軟骨細胞の再分化促進因子/低分子化合物の網羅的探索
Papers (23):
  • Tomonori Ozaki, Tatsuya Kawamoto, Yuki Iimori, Nobuaki Takeshita, Yukiko Yamagishi, Hiroaki Nakamura, Masazumi Kamohara, Kaori Fujita, Masayuki Tanahashi, Noriyuki Tsumaki. Evaluation of FGFR inhibitor ASP5878 as a drug candidate for achondroplasia. Scientific Reports. 2020. 10. 1
  • Kaori Fujita. p53 Isoforms in Cellular Senescence- and Ageing-Associated Biological and Physiological Functions. International Journal of Molecular Sciences. 2019. 20. 23. 6023-6023
  • Kosai A, Horike N, Takei Y, Yamashita A, Fujita K, Kamatani T, Tsumaki N. Changes in acetyl-CoA mediate Sik3-induced maturation of chondrocytes in endochondral bone formation. Biochem Biophys Res Commun. 2019. 516. 4. 1097-1102
  • Kimura T, Ozaki T, Fujita K, Yamashita A, Morioka M, Ozono K, Tsumaki N. Proposal of patient-specific growth plate cartilage xenograft model for FGFR3 chondrodysplasia. Osteoarthritis and Cartilage. 2018. 26. 11. 1551-1561
  • Kobayashi T, Fujita K, Kamatani T, Matsuda S, Tsumaki N. A-674563 increases chondrocyte marker expression in cultured chondrocytes by inhibiting Sox9 degradation. Biochemical and biophysical research communications. 2018. 495. 1. 1468-1475
more...
MISC (7):
  • Yasuhito Yahara, Hiroshi Takemori, Minoru Okada, Azuma Kosai, Akihiro Yamashita, Tomohito Kobayashi, Kaori Fujita, Yumi Itoh, Masahiro Nakamura, Hiroyuki Fuchino, et al. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3 (vol 7, 10959, 2016). NATURE COMMUNICATIONS. 2016. 7
  • 山下晃弘, 森岡美帆, 岸宏美, 木村武司, 箭原康人, 岡田稔, 藤田香里, 澤井英明, 池川志郎, 妻木範行. スタチンによるFGFR3軟骨形成異常症の病態回復. 日本軟骨代謝学会プログラム・抄録集. 2016. 29th
  • Izumi Horikawa, Kaori Fujita, Lisa Miller Jenkins, Yukiharu Hiyoshi, Abdul M. Mondal, Borivoj Vojtesek, David P. Lane, Ettore Appella, Curtis C. Harris. Autophagic degradation of Delta 133p53 during replicative cellular senescence: An isoform-specific protein degradation mechanism for p53. CANCER RESEARCH. 2013. 73
  • Abdul Matin Mondal, Lzumi Horikawa, Sharon R. Pine, Kaori Fujita, Borivoj Vojtesek, Jean-Christophe Bourdon, Elsa Vera, David P. Lane, Maria A. Blasco, Curtis C. Harris. p53 isoforms, Delta 133p53 and p53 beta, regulate aging-associated T lymphocyte senescence. CANCER RESEARCH. 2011. 71
  • Izumi Horikawa, Kaori Fujita, Curtis C. Harris. p53 governs telomere regulation feedback too, via TRF2. AGING-US. 2011. 3. 1. 26-32
more...
Patents (2):
  • Manipulation of stem cell function by p53
  • Therapeutic application of p53 isoforms in regenerative medicine, aging and cancer
Education (2):
  • 1995 - 2000 Tohoku University
  • - 1995 Tohoku University
Professional career (1):
  • Ph. D (Tohoku University)
Work history (8):
  • 2021/04 - 現在 Faculty and Graduate School of Engineering Science, Akita University Department of Life Science
  • 2016/04 - 2021/03 Center for iPS Cell Research and Application, Kyoto University Department of Clinical Application
  • 2012/01 - 2016/03 Center for iPS Cell Research and Application, Kyoto University Dept. of Cell Growth and Differentiation Researcher
  • 2010/01 - 2012/01 National Cancer Institute, National Institutes of Health Lab. of Human Carcinogenesis Research Fellow
  • 2005/02 - 2010/01 National Cancer Institute, National Institutes of Health Lab. of Human Carcinogenesis Visiting Fellow
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Committee career (2):
  • 2016/11 - 2017/07 日本学術振興会 科学研究費助成事業 第1段階(書面審査)審査委員
  • 2015/11 - 2016/07 日本学術振興会 科学研究費助成事業 第1段階(書面審査)審査委員
Association Membership(s) (3):
日本癌学会 ,  日本分子生物学会 ,  International Cell Senescence Association
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