Rchr
J-GLOBAL ID：200901067980798521
Update date: Apr. 30, 2024
Yoshimitsu Takehiko
ヨシミツ タケヒコ | Yoshimitsu Takehiko
Affiliation and department：
Job title：
Professor
Research field (1)：
Pharmaceuticals - chemistry and drug development
Research keywords (6)：
医薬化学
, 天然物合成
, 有機合成化学
, medicinal chemistry
, Natural product synthesis
, Synthetic organic chemistry
Research theme for competitive and other funds (12)：
- 2021 - 2024 ラジカル反応を駆動する新規触媒の創製と天然物合成
- 2018 - 2022 Development of synthetic strategies towards bioactive polycyclic natural products via catalytic radical cascade transformations
- 2015 - 2018 Development of new therapeutic agents derived from Wnt signaling inhibitor for treating brain cancer
- 2012 - 2016 Development of New Means of Asymmetric Halogenation and Total Synthesis of Bioactive Halogenated Natural Products
- 2010 - 2015 Development of synthetic methodology to supply materials for understanding of physiological system
- 2009 - 2012 Development of new radical chemistry-based strategies for the construction of densely functionalized organic molecules
- 2007 - 2008 Studies on the total synthesis of nitrogen-containing natural organic compounds aimed at the development of anticancer and analgesic research
- 2006 - 2008 Development of novel metal-mediated reaction and their application to domino cyclization
- 2006 - 2007 HIF-1α阻害剤マナサンチンBのバイオプローブ化
- 2004 - 2006 細胞増殖抑制新規多ハロゲン化スルホリピッド類の不斉全合成と医薬資源開拓
- 2002 - 2003 エーテル類のsp3C-H結合活性化反応の開発と天然物合成への活用
- 2000 - 2001 Rasファルネシル化酵素阻害活性を有するCP-263,114の全合成研究
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Papers (3)：
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Yoshimitsu Takehiko, Fukumoto Naoya, Nakatani Ryo, Kojima Naoto, Kobayashi Akihiro, Tanaka Tetsuaki. Asymmetric Total Synthesis of Chlorosulfolipid. Symposium on the Chemistry of Natural Products, symposium papers. 2010. 52. 7-12
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Shun-Ichi Murahashi, Yoshinori Yamamoto, Gan B. Bajracharya, Claudio Nicolau, Mikel Oiarbide, Yoshitaka Hamashima, Mikiko Sodeoka, Armando Córdova, Barry B. Snider, Takehiko Yoshimitsu, et al. C-H Transformation at Functionalized Alkanes. Handbook of C-H Transformations: Applications in Organic Synthesis. 2008. 2. 317-496
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OHSHIBA Yukio, YOSHIMITSU Takehiko, OGASAWARA Kunio. Practical chiral route to muscarine and its three diastereomers. Chemical and Pharmaceutical Bulletin. 1995. 43. 6. 1067-1069
MISC (64)：
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Yusuke Okanishi, Otoki Takemoto, Sanpou Kawahara, Satoshi Hayashi, Toshikatsu Takanami, Takehiko Yoshimitsu. Red-Light-Promoted Radical Cascade Reaction to Access Tetralins and Dialins Enabled by Zinc(II)porphyrin, A Light-Flexible Catalyst. Organic Letters. 2024
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Daigo Sawaki, Yanyan Zhang, Amel Mohamadi, Maria Pini, Zaineb Mezdari, Larissa Lipskaia, Suzain Naushad, Lucille Lamendour, Dogus Murat Altintas, Marielle Breau, et al. Osteopontin promotes age-related adipose tissue remodeling through senescence-associated macrophage dysfunction. JCI Insight. 2023. 8. 8
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Yusuke Okanishi, Tohru Ishikawa, Takuya Jinnouchi, Satoshi Hayashi, Toshikatsu Takanami, Hiroshi Aoyama, Takehiko Yoshimitsu. Radical-Based Route to Functionalized Tetralin: Formal Total Synthesis of (±)-Hamigeran B. The Journal of Organic Chemistry. 2023. 88. 2. 1085-1092
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Taejoo Jeong, Yusuke Okanishi, Sora Yotsui, In Su Kim, Takehiko Yoshimitsu. Organic redox cascade cyclization of 2-alkynylquinones by ascorbic acid in combination with a copper catalyst and its application to formal synthesis of liphagal. New Journal of Chemistry. 2023. 47. 7. 3425-3429
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Thomas R. Caulfield, Karen E. Hayes, Yushi Qiu, Mathew Coban, Joon Seok Oh, Amy L. Lane, Takehiko Yoshimitsu, Lori Hazlehurst, John A. Copland, Han W. Tun. A Virtual Screening Platform Identifies Chloroethylagelastatin A as a Potential Ribosomal Inhibitor. Biomolecules. 2020. 10. 10. 1407-1407
ｍore...
Books (5)：
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クロロスルホリピッド-全合成の新たな標的-
化学工業 2014
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Stereoselective Synthesis of Halogenated Natural Products, Chapter 43
John Wiley & Sons 2013
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Triethylborane in Handbook of Reagents for Organic Synthesis; Reagents for Direct Functionalization of C-H Bonds
Wiley-VCH 2006
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Triethylborane in Encyclopedia of Reagents for Organic Synthesis
John Wiley & Sons 2005
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Radical Alpha-Functionalization of Ethers in Handbook of C-H Transformations
Wiley VCH Verlag GmbH 2005
Education (5)：
- 1992 - 1995 Tohoku University Graduate School of Pharmaceutical Sciences
- - 1995 Tohoku University Graduate School, Division of Pharmaceutical Sciences
- 1990 - 1992 Tohoku University Graduate School of Pharmaceutical Sciences
- 1986 - 1990 Tohoku University Faculty of Pharmaceutical Sciences
- - 1990 Tohoku University Faculty of Pharmaceutical Science
Professional career (1)：
Work history (12)：
- 2016 - 2018 Osaka University
- 2006 - 2016 Osaka University
- 2006 - 2016 Associate Professor,Graduate School of Pharmaceutical Sciences
- 2016 - - 岡山大学医歯薬学総合研究科 教授
- 2016 - - Professor,Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama University
- 2013 - The University of Tokushima Faculty of Engineering, Department of Chemical Science and Technology
- 2012 - Kyushu University Institute for Materials Chemistry and Engineering
- 2003 - 2006 Meiji Pharmaceutical University
- 2003 - 2006 Senior Assistant Professor
- 1997 - 2003 Meiji Pharmaceutical University
- 1997 - 2003 Research Associate
- 1995 - 1997 Massachusetts Institute of Technology
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Committee career (12)：
- 2020/04 - 2022/03 日本薬学会 代議員
- 2007/04 - 2017/03 日本薬学会 日本薬学会近畿支部委員
- 2013/04 - 2016/03 日本薬学会 代議員
- 2011/04 - 2013/03 公益社団法人有機合成化学協会 有機合成化学協会誌編集協力委員
- 2009/04 - 2011/03 公益社団法人日本薬学会 ファルマシアトピックス専門小委員
- 2010/05 - 2010/05 The 5th Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists Organizing committee member
- 2009/07 - 2009/07 第7回次世代を担う有機化学シンポジウム 実行委員長
- 2009/07 - 2009/07 第3回日本薬学会化学系薬学部会若手教員会議 議長
- 2008/05 - 2008/05 第6回次世代を担う有機化学シンポジウム 世話人
- 2008/03 - 2008/03 第128会日本薬学会一般シンポジウム「分子の新機能が拓く有機合成化学」 オーガナイザー
- 2007/05 - 2007/05 第5回次世代を担う有機化学シンポジウム 世話人
- 2006/11 - 2006/11 The 3rd Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists Scientific Committee Member
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Awards (8)：
- 2024/03 - Electric Technology Research Foundation of Chugoku Scientific Award
- 2023 - The Okayama Foundation for Science and Technology Scientific Award from The Okayama Foundation for Science and Technology
- 2014 - 大阪大学総長による表彰
- 2014 - Presidential Awards for Excellence (Osaka University)
- 2013 - アジア最先端有機化学国際会議 Asian Core Program (ACP) Lectureship Award (Singapore)
- 2013 - 第11回 有機合成化学協会関西支部賞
- 2013 - The Society of Synthetic Organic Chemistry, Japan. The 11th Kansai Branch Award
- 2008 - アジア最先端有機化学国際会議 Asian Core Program (ACP) Lectureship Award (Thailand)
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