2017 - 2020 Development of a novel mucosal vaccine applying the immune memory function of nasopharyngeal-related lymphoid tissue (NALT)
2017 - 2020 Development of nasal boost immunization with phosphorylcholine as a novel pneumococcal vaccination program
2016 - 2019 Development of novel mucosal vaccine by applying the biphasic reaction of phosphorylcholine
2016 - 2019 Transcutaneous immunization with phosphorylcholine induces antigen-specific mucosal and systemic immune responses
2013 - 2016 Application of phosphorylcholine for multi-functional mucosal vaccine
2010 - 2012 Transcutaneous immunization induces antigen specific mucosal and syatemic immune responses in mice
2010 - 2012 New therapy for refractory chronic sinusitis in application with priming effect of macrolide on steroid therapy
2008 - 2010 Sublingual immunization-A new vaccination route for mucosa immunity and protection of upper respiratory infection
2007 - 2008 Relationships among sleep disorders, sleep bruxism, psychological stress, respiratory and gastroesophageal symptoms and maxillofacial morphology in children
2005 - 2007 Development of a novel nasal vaccine having wide spectrum activity for upper respiratory infections
2003 - 2005 Examination of the gene therapy for OME using Decoy oligo.
2002 - 2004 The mechanism in the diversity and amplification of mucosal immune system -Clinical application of mucosal vaccine-
2000 - 2004 環太平洋地域におけるがんの要因探索
2001 - 2003 Research about the mucosal vaccine against Haemophilus influenzae consist of recombinat antigen
1999 - 2001 Vascular endotherial growth factor )VEGF) in paranasal sinusitis and allergic rhinitis
1999 - 2001 Application of mucosal vaccine against upper respiratory tract infections
1999 - 2000 The Study on Cytokine Production of Helper T cell and its Therapeutic Effect in Allergic Rhinitis
1998 - 1999 The mucosal immune system of the upper respiratory tract and development of nasal vaccine for upper respiratory tract infection
1997 - 1999 The Mechanisms of Mucosal Immune Responses in Adenoid and Tonsil (NALT)
1997 - 1998 Gene expression of cell diferenciation related factors of respiratory epithelium and its roll in the mucosal pathology of rhino sinusitis
1996 - 1998 Evaluation of gustatory functions by using new methods to qualify eating behavior.
1995 - 1997 The Role and Mechanism of Mucosal Immune Responses against Outer Membrane Proteins of Haemophilus influenzae.
1994 - 1995 Immunological Treatment against Upper Respiratory Tract Infection caused by Haemophilus influenzae ; The Roleof Mucosal Immunity
1988 - 1990 Efiology and Treatment of Recurrent Ofitics Media
慢性上気道疾患に対するマクロライド療法
アレルギー性鼻炎発症機序の解明
インフルエンザ菌ワクチンによる中耳炎予防
Macrolide therapy against chronic upper respiratory inflammations.
Analysis of the pathogenesis inducing allergic rhinitis.
Protection of otitis media with vaccine of Haemophilus inflnenzae
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Papers (162)：
Rika Nakahashi-Ouchida, Hiromi Mori, Yoshikazu Yuki, Shingo Umemoto, Takashi Hirano, Yohei Uchida, Tomonori Machita, Tomoyuki Yamanoue, Shin-Ichi Sawada, Masashi Suzuki, et al. Induction of Mucosal IgA-Mediated Protective Immunity Against Nontypeable Haemophilus influenzae Infection by a Cationic Nanogel-Based P6 Nasal Vaccine. Frontiers in immunology. 2022. 13. 819859-819859
