Rchr
J-GLOBAL ID:200901068619985089
Update date: Feb. 14, 2024
Keizo Takeshita
Keizo Takeshita
Affiliation and department:
Sojo University FACULTY OF PHARMACEUTICAL SCIENCES
About Sojo University FACULTY OF PHARMACEUTICAL SCIENCES
Search "Sojo University FACULTY OF PHARMACEUTICAL SCIENCES"
Detailed information
Job title:
Professor
Homepage URL (2):
https://yohta7.wixsite.com/takeshita-lab
,
https://yohta7.wixsite.com/takeshita-lab/english
Research field (1):
Pharmaceuticals - analytical and physicochemistry
Research keywords (13):
MRI
, ESR
, in vivo measurement
, スピントラップ
, スピンラベル
, フリーラジカル
, イメージング
, 生体計測
, 活性酸素
, 光増感
, DDS
, がん
, セラノスティックス
Research theme for competitive and other funds (26):
2019 - 2022 がん間質領域に選択的な悪性度指標の磁気共鳴診断法の開発
2015 - 2018 Development of a redox sensitive liposome for diagnosis and treatment for liver damages
2013 - 2018 Development of traceable photosensitizer to produce enough effect of photodynamic therapy
2012 - 2015 The development of the non-invasive redox measurement technique with liver-targeting liposomes.
2012 - 2013 化学発光法による生体内分子の高感度測定法の実用化
2010 - 2012 Development of contrast agents having multi-function of diagnosis and therapy for effective photodynamic therapy of cancers
2007 - 2008 Basic study for development of multi imaging system of redox-related information in tumors
2006 - 2007 Study of noninvasive measurement for skin's oxidative stress and damage by irradiation of UV
2005 - 2006 Study on non-invasive measurement of biological redox for diagnosis of chronic diseases
2003 - 2006 Analysis of free radical reactions in diseases model animals using in vivo ESRI
2002 - 2003 Development for measuring the concentration of hydrogen peroxide in vivo using ESR equipment
2001 - 2003 Development of ESRI・MRI fused imaging device for oxidative stress-related diseases
2001 - 2002 Development of new probes for medical imaging of cancer
2001 - 2002 Establishnent of In vivo ESR Imaging System for Oxidativte Stress in Brain
2000 - 2001 In Vivo Measurement of Reactive Oxygen Species Generated in Skin under Ultraviolet Light Irradiation
1998 - 2001 Development of non-invasive evaluation of oxidative stress against living organisms by in vivo ESR
1998 - 1999 Analysis of toxicity by organic halogens with in vivo ESR and transgenic mice
1995 - 1997 Roles of in vivo REDOX systems by using in vivo ESR and transgenic mice
1996 - 1996 脳細胞の生存・機能維持におけるフリーラジカルの関与
1996 - 1996 生体内で発生する活性酸素の無侵襲検出法の開発
1994 - 1994 L-バンドESRによる肺内還元機構の解析
1993 - 1993 非特定多様有害物質の毒性低減化に向けた新評価法の開発
1991 - 1993 Study of Free Radicals in Tissue and Transdermal Drug Delivery by using in vivo ESR with Spectral-Spatial ESR-CT Imaging
1990 - 1992 Real Time Analysis of Drug-Diffusion in Muscle with in vivo ESR-Spectroscopy
1991 - 1991 肺に於ける活性酸素消去機構とその画像化解析
1990 - 1990 肺に於けるラジカル消失と大気汚染物質防御機構との関連に関するinvivo画像解析
Show all
Papers (67):
Keizo Takeshita, Megumi Ueno, Kaori Fujii-Aikawa, Shoko Okazaki, Yuhei Ohta, Toshihiko Ozawa. Protective effects of 2-aminoethylthiosulfuric acid and structurally analogous organosulfur compounds against ionizing radiation. Journal of clinical biochemistry and nutrition. 2023. 72. 2. 117-125
Makoto Anraku, Yasuyuki Mizukai, Yuji Maezaki, Kazuo Kawano, Shoko Okazaki, Keizo Takeshita, Tomoki Adachi, Masaki Otagiri, Daisuke Iohara, Fumitoshi Hirayama. The preparation and validation of chitosan tablets that rapidly disperse and disintegrate as an oral adsorbent in the treatment of lifestyle-related diseases. Carbohydr Polym. 2021. 253. 117246
Keizo Takeshita, Hana Okazaki, Megumi Tsukamoto, Shoko Okazaki. Differences in pharmacokinetic behaviors of two lipophilic 3-substituted 2,2,5,5-tetramethylpyrrolidine-N-oxyl radicals, in vivo probes to assess the redox status in the brain using magnetic resonance techniques. Magn. Reson. Med. 2021. 85. 1. 560-569
Shoko Okazaki, Ayako Hirata, Yusuke Shogomori, Megumi Takemoto, Takuro Nagata, Eriko Hayashida, Keizo Takeshita. Radical reactions induced by ketoprofen in phospholipid membranes under ultraviolet light irradiation. J. Photochem. Photobiol. B:Biology. 2021. 214. 112090
Keita Saito, Shoko Okazaki, Yoko Tachibana, Kazunori Anzai, Toshihiko Ozawa, Keizo Takeshita. In vivo ESR imaging of redox status in mice after X-ray irradiation, measured by acyl-protected hydroxylamine probe, ACP. Free Radic. Biol. Med. 2020. 160. 596-603
more...
MISC (5):
Shoko Okazaki, Yukori Koga, Toshiki Masumizu, Keizo Takeshita. Photo-induced radical reduction by methyl gallate. FREE RADICAL BIOLOGY AND MEDICINE. 2007. 43. S17-S17
J Han, K Takeshita, H Utsumi. Pharmacokinetics of nitroxyl probe in mouse lung in vivo ESR study. FREE RADICAL BIOLOGY AND MEDICINE. 2003. 35. S118-S118
K Takeshita, CP Chi, H Hirata, M Ono, H Suzaki, T Ozawa. In vivo ESR study on radical generation in mouse skin under ultraviolet light. FREE RADICAL BIOLOGY AND MEDICINE. 2002. 33. S176-S176
K Takeshita, H Majima, T Ozawa. In vivo measurement of oxidative stress caused by irradiation of heavy ion beam. FREE RADICAL BIOLOGY AND MEDICINE. 1999. 27. S136-S136
K TAKESHITA, H UTSUMI, A HAMADA. DYNAMICS OF LIPID HAPTEN IN LIPOSOMAL MEMBRANES AND ITS RELATION TO PHASE-TRANSITION OF HOST LATTICE. JOURNAL OF PHARMACOBIO-DYNAMICS. 1986. 9. 9. S115-S115
Patents (1):
スーパーオキシドの分析方法およびスーパーオキシドの分析キット
Books (13):
アップデート薬学機器分析学
廣川書店 2020
Frontier Science of Photoaging
2015 ISBN:9784781310688
実験実習の基本とデータのまとめ方 -実験レポートから卒業研究発表まで -
三恵社 2015 ISBN:9784864873376
敗血症の診断/治療の実状と病態・メカニズムをふまえた開発戦略
技術情報協会 2013 ISBN:9784861044892
基礎薬学分析化学 II(中村 洋 編)第4版
廣川書店 2011 ISBN:9784567255370
more...
Lectures and oral presentations (73):
生活習慣病の治療における経口吸着剤としての造粒キトサン錠の調製と評価
(日本薬学会第141年会 2021)
リポソーム膜内で紫外線照射によりケトプロフェンが惹起するラジカル反応
(日本薬学会第141年会 2021)
紫外線照射によりケトプロフェンが惹起するリポソーム膜内ラジカル反応と膜傷害
(第59回電子スピンサイエンス学会年会 2020)
中枢神経系疾患モデルマウスにおける脳内レドックスイメージング
(日本薬学会第140年会 2020)
紫外線照射下のケトプロフェンが惹起したラジカル反応によるリポソーム膜の傷害
(日本薬学会第140年会 2020)
more...
Education (3):
1981 - 1984 Showa University Graduate School, Division of Pharmaceutical Sciences Health Chemistry
1979 - 1981 Showa University Graduate School, Division of Pharmaceutical Sciences Health Chemistry
1975 - 1979 Showa University Faculty of Pharmaceutical Science
Professional career (2):
Master (Showa University)
Ph.D. (Showa University)
Work history (14):
2012/04/01 - 現在 /(DC)Division of Pharmaceutical Sciences
2009/04/01 - 現在 Graduate School of Engineering Graduate School of Engineering /Division of Applied Chemistry
2005/04 - 現在 National Institute of Radiological Sciences Researcher
2005/04/01 - 現在 FACULTY OF PHARMACEUTICAL SCIENCES FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences
2001/04 - 2005/03 National Institute of Radiological Sciences Redox Regulation Research Group Chief Researcher
2003/04 - 2004/03 Kyushu University, Graduate School of Pharmaceutical Sciences
2001/03 - 2001/06 National Institute of Health (NIH) National Cancer Institute Guest Researcher
1998/06 - 2001/03 National Institute of Radiological Sciences Bioregulation Research Groop Chief Researcher
1994/08 - 1998/05 Kyushu University Faculty of Pharmaceutical Sciences Research Associate
1994/06 - 1994/07 Kyushu University Faculty of Pharmaceutical Sciences
1991/07 - 1994/05 Showa University School of Pharmaceutical Sciences Lecturer
1984/05 - 1991/06 Showa University School of Pharmaceutical Sciences Research Associate
1987/04 - 1989/04 Northwestern University Department of Biochemistry, Molecular Biology and Cell Biology postdoc
1984/04 - 1984/05 Showa University School of Pharmaceutical Sciences Part-time researcher for university or other academic organization
Show all
Committee career (15):
2008/04 - 現在 日本酸化ストレス学会(旧 日本フリーラジカル学会) 評議委員
2005/09 - 現在 日本酸化ストレス学会(旧 日本フリーラジカル学会) ,J. Clin. Biochem. Nutr. 誌編集委員
2013/01 - 2014/12 電子スピンサイエンス学会 会長
2011/01 - 2012/12 電子スピンサイエンス学会 副会長
2008/01 - 2012/03 電子スピンサイエンス学会 会誌編集アドバイザー
2006/01 - 2009/12 電子スピンサイエンス学会 理事
2006/04 - 2009/03 日本薬学会 Biological & Pharmaceutical Bulletin 誌編集委員
2006/01 - 2007/12 電子スピンサイエンス学会 編集担当理事、会誌編集委員長
2004/11 - 2007/06 日本過酸化脂質・フリーラジカル学会 評議委員
2005/04 - 2007/03 日本薬学会 ファルマシアアドバイザー
2005/08 - 2005/12 電子スピンサイエンス学会 学会賞・奨励賞選考委員
2003/01 - 2005/12 電子スピンサイエンス学会 会誌編集委員
2004/04 - 2005/03 日本薬学会 ファルマシア委員
1994/06 - 1995/03 日本薬学会 ファルマシアトピックス専門委員
1993/04 - 1994/05 日本薬学会 ファルマシアトピックス小委員
Show all
Awards (1):
2017/11 - (一社)電子スピンサイエンス学会 学会賞 電子スピン共鳴法によるレドックス・活性酸素の生体計測とラジカル反応解析に関する研究
Association Membership(s) (7):
Society for Redox Biology & Medicine
, Society for Free Radical Biology and Medicine
, The Society of Electron Spin Science and Technology (SEST)
, 日本過酸化脂質・フリーラジカル学会
, 日本酸化ストレス学会(旧 日本フリーラジカル学会)
, 日本薬学会
, 日本生化学会
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in
researchmap
.
For details, see here
.
Return to Previous Page
TOP
BOTTOM