Rchr
J-GLOBAL ID：200901068671950609   Update date: May. 12, 2024

Wakasugi Mitsuo

ワカスギ ミツオ | Wakasugi Mitsuo
Affiliation and department：
Kanazawa University Institute of Medical,Pharmaceutical and Health Sciences, Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Pharmacy

About Kanazawa University Institute of Medical,Pharmaceutical and Health Sciences, Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Pharmacy


Job title： Associate Professor
Research field  (5)： Pharmacology ,  Pharmaceuticals - health and biochemistry ,  Molecular biology ,  Environmental effects of chemicals ,  Environmental effects of radiation
Research keywords  (3)： DNA損傷応答 ,  DNA修復 ,  DNA repair Damage response
Research theme for competitive and other funds  (18)：
  • 2019 - 2022 Chemical approaches to understand the complex mechanism of nucleotide excision repair
  • 2019 - 2021 NER中間体がもたらす新たなDNA損傷生成とその防御機構の解析
  • 2016 - 2019 Mechanistic analysis of novel DNA repair inhibitors and their possible application to anticancer therapy
  • 2016 - 2018 Analysis of the mechanism of a novel DNA repair reaction in mammalian cells
  • 2016 - 2018 休止期のヌクレオチド除去修復により生じる二次的DNA損傷とゲノム恒常性維持機構
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Papers (28)：
  • Saki Horie, Kenji Mishiro, Mio Nishino, Inori Domae, Mitsuo Wakasugi, Tsukasa Matsunaga, Munetaka Kunishima. Epitope-Based Specific Antibody Modifications. Bioconjugate chemistry. 2023. 34. 11. 2022-2033
  • Ryo Akahori, Chie Takamori, Mitsuo Wakasugi, Tsukasa Matsunaga. Mapping of the regions implicated in nuclear localization of multi-functional DNA repair endonuclease XPF-ERCC1. Genes to Cells. 2022. 27. 5. 356-367
  • Ryo Sakasai, Mitsuo Wakasugi, Tadashi Matsui, Yumi Sunatani, Masafumi Saijo, Tsukasa Matsunaga, Kuniyoshi Iwabuchi. Camptothecin compromises transcription recovery and cell survival against cisplatin and ultraviolet irradiation regardless of transcription-coupled nucleotide excision repair. DNA repair. 2022. 113. 103318-103318
  • Liton Kumar Saha, Mitsuo Wakasugi, Salma Akter, Rajendra Prasad, Samuel H. Wilson, Naoto Shimizu, Hiroyuki Sasanuma, Shar-yin Naomi Huang, Keli Agama, Yves Pommier, et al. Topoisomerase I-driven repair of UV-induced damage in NER-deficient cells. Proceedings of the National Academy of Sciences. 2020. 201920165-201920165
  • Hiroaki Kawara, Ryo Akahori, Mitsuo Wakasugi, Aziz Sancar, Tsukasa Matsunaga. DCAF7 is required for maintaining the cellular levels of ERCC1-XPF and nucleotide excision repair. Biochemical and Biophysical Research Communications. 2019. 519. 1. 204-210
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MISC (7)：
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Lectures and oral presentations  (3)：
  • Modulation of nucleotide excision repair in human cells
    (International Conference on Radiation and Cancer Biology in Nagasaki 2010 2010)
  • DT40細胞におけるDDB1欠損が細胞周期とDNA損傷応答に及ぼす影響
    (第30回日本分子生物学会年会・第80回日本生化学会大会合同大会 ワークショップ「ユビキチン化を介したゲノムダイナミクスの制御」 2007)
  • Functional analysis of DDB in DNA repair and cell growth
    (International Symposium on Tumor Biology in Kanazawa 2006 2006)
Education (3)：
  • 1993 - 1996 Kanazawa University Graduate School of Natural Science and Technology Division of Life Sciences
  • 1991 - 1993 Kanazawa University
  • 1987 - 1991 Kanazawa University Faculty of Pharmaceutical Sciences Department of Pharmacy
Professional career (1)：
  • 博士(薬学) (金沢大学)
Work history (6)：
  • 2017/04 - 現在 Kanazawa University Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Pharmacy
  • 2008/04 - 2017/03 Kanazawa University Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Pharmacy
  • 2007/04 - 2008/03 Kanazawa University Graduate School of Natural Science and Technology
  • 2004/04 - 2007/03 Kanazawa University
  • 2002/04 - 2004/03 Kanazawa University Faculty of Pharmaceutical Sciences
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Awards (1)：
  • 2004 - 研究奨励金(研究助成)
Association Membership(s) (4)：
THE PHARMACEUTICAL SOCIETY OF JAPAN ,  日本放射線影響学会 ,  日本分子生物学会 ,  日本癌学会
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