Ishihara Keiichi

イシハラケイイチ | Ishihara Keiichi

Affiliation and department：

Research field (3)： Pharmaceuticals - health and biochemistry , Cell biology , Molecular biology

Research keywords (4)： cognitive function , developmental delay , mouse model , Down syndrome

Research theme for competitive and other funds (14)：

2022 - 2025 Understanding the mechanisms underlying bran developmental retardation in Down syndrome
2022 - 2024 Understanding the mechanisms underlying copper accumulation in the brain with Down syndrome
2020 - 2024 脳内免疫環境変化の解析によるアルツハイマー病の病態解明と治療への応用
2020 - 2022 Identification of responsible gene(s) for accumulation of copper in the brain of Down syndrome and its role in intellectual disability
2018 - 2021 A study on abnormal cerebrovascular function and accelerated inflammation in the developing brain with Down syndrome

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Papers (56)：

KEIICHI ISHIHARA, RYUTO SAKODA, MASAKO MIZOGUCHI, MITSUGU FUJITA, CHIAMI MOYAMA, YURI OKUTANI, KAZUYUKI TAKATA, MIWA TANAKA, TAKASHI MINAMI, HARUHIKO SAGO, et al. Suppression ofSleeping Beauty-induced Gliomagenicity in Ts1Cje Mice, a Model of Down Syndrome. Anticancer Research. 2024. 44. 2. 489-495
Keiichi Ishihara, Kazuyuki Takata, Ken-Ichi Mizutani. Involvement of an Aberrant Vascular System in Neurodevelopmental, Neuropsychiatric, and Neuro-Degenerative Diseases. Life (Basel, Switzerland). 2023. 13. 1
Keiichi Ishihara, Eri Kawashita, Satoshi Akiba. Bio-Metal Dyshomeostasis-Associated Acceleration of Aging and Cognitive Decline in Down Syndrome. Biological & pharmaceutical bulletin. 2023. 46. 9. 1169-1175
Takeyoshi Ozaki, Eri Kawashita, Keiichi Ishihara, Satoshi Akiba. Deficiency of Group IVA Phospholipase A2 in Collagen-Producing Cells Alleviates the Aggravated Hepatic Fibrosis in High-Fat Diet-Fed Mice after Returning to a Normal Diet. Biological & pharmaceutical bulletin. 2023. 46. 3. 488-493
Aina Fukuda, Souichi Nakashima, Yoshimi Oda, Kaneyasu Nishimura, Hidekazu Kawashima, Hiroyuki Kimura, Takashi Ohgita, Eri Kawashita, Keiichi Ishihara, Aoi Hanaki, et al. Plantainoside B in Bacopa monniera binds to Aβ aggregates attenuating neuronal damage and memory deficits induced by Aβ. Biol. Pharm. Bull. 2022. 46. 2. 320-333

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MISC (57)：

石原慶一. 【生命と金属~その動態制御と解析法の最前線~】ダウン症候群の認知機能障害と生命金属恒常性破綻. ファルマシア. 2023. 59. 3. 206-211
三崎友菜, 河下映里, 西村周泰, 石原慶一, 野口鈴華, 高田和幸, 松尾理, 秋葉聡. Examination of the involvement of α2-antiplasmin in survival and maturation of transplanted neural progenitor cells. 日本薬学会年会要旨集(Web). 2023. 143rd
西村美紅, 河下映里, 永井信夫, 石原慶一, 井上和奏, 宮崎優奈, 松尾理, 秋葉聡. Involvement of α2-antiplasmin in neurogenesis after cerebral infarction. 日本薬学会年会要旨集(Web). 2023. 143rd
福田愛菜, 中嶋聡一, 中嶋聡一, 尾田好美, 尾田好美, 西村周泰, 西村周泰, 河嶋秀和, 木村寛之, 扇田隆司, et al. Detection of Aβ aggregates and neuroprotection by plantainoside B, an Aβ-binding compound from Bacopa monniera. 日本薬学会年会要旨集(Web). 2023. 143rd
千代華歩, 河下映里, 秋葉聡, 山川和弘, 石原慶一. Correlation between brain copper accumulation and emotional memory impairment in mouse models of Down syndrome. 日本薬学会年会要旨集(Web). 2023. 143rd

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Lectures and oral presentations (4)：

Suppressive effects of Down syndrome genes on amyloid-β aggregation and mortality in a mouse model of Alzheimer’s disease
(2022)
Brain Copper Accumulation-Associated Cognitive Impairment in Mouse Models of Down Syndrome
(10th Asian Biological Inorganic Chemistry Conference 2022)
ダウン症マウスモデル脳の異常表現型と発現変動分子
(第39回日本分子生物学会年会 2016)
創薬標的の同定を目的としたダウン症マウス脳での変動分子の網羅的解析
(日本薬学会第136年会 2016)

Education (4)：

- 2001 Kyoto Pharmaceutical University Graduate School of Pharmaceutical Sciences
- 2001 Kyoto Pharmaceutical University Graduate School, Division of Pharmaceutical Sciences
- 1996 Kyoto Pharmaceutical University Pharmaceutical Sciences Pharmaceutical Biology
- 1996 Kyoto Pharmaceutical University Faculty of Pharmaceutical Science

Professional career (1)：

Work history (6)：

2020/01 - 現在 Kyoto Pharmaceutical University Department of Pathological Biochemistry Associate Professor
2010/04 - 2019/12 Kyoto Pharmaceutical University Department of Pathological Biochemistry Lecturer
2009/04 - 2010/03 Kyoto Pharmaceutical University Department of Pathological Biochemistry Assistant Professor
2006/03 - 2009/03 RIKEN BSI Lab for Neurogenetics Research fellow
2005/04 - 2006/02 University of Nebraska Medical Center Department of Ophthalmology & Visual Sciences Postdoctral research fellow

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Association Membership(s) (4)：

日本神経化学会 , 日本薬学会 , 日本分子生物学会 , 日本生化学会

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