Yokoyama Yukihiro

• 2013 - 2016 TLR7アプタマーによる内因性Danger Signalの制御と新規治療法の開発
• 2013 - 2016 乳癌におけるChromothripsis変異を標的にした新規治療法の開発
• 2013 - 2016 分子進化の概念に基づく新規遺伝子の探索と機能解析
• 2012 - 2016 新規セリンスレオニンキナーゼ阻害剤による胆管 癌・膵癌治療法の開発
• 2013 - 2016 分子進化の概念に基づく新規遺伝子の探索と機能解析
2013 - 2015 肝虚血再潅流障害における分枝鎖アミノ酸の新規分子機構の探索
2012 - 2015 膵癌における新規治療抵抗性遺伝子の探索とその阻害剤による治療法の開発
2012 - 2014 肝切除時におけるリアルタイム肝機能モニタリングシステムの開発と臨床応用
2011 - 2014 食道癌に対する相互マシンラーニング法によるHedgehog新規阻害剤の開発
2011 - 2014 癌における細胞老化関連遺伝子の探索と臨床応用
2012 - 2013 化学療法関連肝障害の外科手術への影響とその病態生理の解明
2010 - 2012 大腸癌 microscopic abscess における網羅的遺伝子解析とその結果に基づく新規癌転移抑制療法の開発
2010 - 2012 微小転移における網羅的遺伝子解析とその結果に基づく新規癌転移抑制療法の開発
2008 - 2012 Nek2を標的にした包括的癌治療法の開発とそのトランスレーショナルリサーチ
2009 - 2011 GGTトランスジェニックマウスを用いた肝虚血/再潅流障害メカニズムの解明
2008 - 2010 急性胆管閉塞にともなう肝障害におけるPPARgammaの役割について
2008 - 2010 複数の癌特異的遺伝子を標的にした分子標的治療の開発
2008 - 2010 肝再生におけるカルシトニンの役割とその分子機構
2007 - 2010 肝門部胆管癌からの胆管癌幹細胞の分離と網羅的遺伝子解析に基づく分子標的治療の開発
2007 - 2009 胆道癌におけるHegdehogシグナル系の発現解析
2007 - 2009 慢性腎不全下における肝切除後肝再生のメカニズムについて
2006 - 2007 胆管閉塞時にみられるパイエル板萎縮のメカニズムについて
2005 - 2007 血管内皮伸展刺激に着目した肝再生メカニズムに関する基礎実験的研究
2004 - 2007 胆管細胞癌の網羅的遺伝子解析とそれに基づく分子標的制癌療法の開発

• Asma Sultana, Mark Brooke-Smith, Shahid Ullah, Joan Figueras, Myrddin Rees, Jean-Nicolas Vauthey, Claudius Conrad, Thomas J. Hugh, O. James Garden, Sheung T. Fan, et al. Prospective evaluation of the International Study Group for Liver Surgery definition of post hepatectomy liver failure after liver resection: an international multicentre study. HPB. 2018. 20. 5. 462-469
• Motoi Nojiri, Yukihiro Yokoyama, Takashi Maeda, Tomoki Ebata, Tsuyoshi Igami, Gen Sugawara, Junpei Yamaguchi, Masato Nagino. Impact of the gastrojejunal anatomic position as the mechanism of delayed gastric emptying after pancreatoduodenectomy. Surgery (United States). 2018. 163. 5. 1063-1070
• Gen Sugawara, Yukihiro Yokoyama, Tomoki Ebata, Tsuyoshi Igami, Junpei Yamaguchi, Takashi Mizuno, Tetsuya Yagi, Masato Nagino. Preoperative biliary colonization/infection caused by multidrug-resistant (MDR) pathogens in patients undergoing major hepatectomy with extrahepatic bile duct resection. Surgery (United States). 2018. 163. 5. 1106-1113
• Kenichi Komaya, Tomoki Ebata, Yukihiro Yokoyama, Tsuyoshi Igami, Gen Sugawara, Takashi Mizuno, Junpei Yamaguchi, Masato Nagino. Recurrence after curative-intent resection of perihilar cholangiocarcinoma: analysis of a large cohort with a close postoperative follow-up approach. Surgery (United States). 2018. 163. 4. 732-738
• Masahito Uji, Yukihiro Yokoyama, Takashi Asahara, Tomoki Ebata, Tsuyoshi Igami, Takashi Mizuno, Junpei Yamaguchi, Masato Nagino. Does the intestinal microenvironment have an impact on the choleretic effect of inchinkoto, a hepatoprotective herbal medicine?. Hepatology Research. 2018. 48. 3. E303-E310

ｍore...

• 膵液漏の予防及び治療
• 内毒素による臓器不全予防剤
• Device for diagnosing condition of liver and method of examing condition of liver
• 肝臓の状態を診断する装置及び肝臓の状態を検査する方法

• 患者さんのための膵がん診療ガイドラインの解説
  金原出版 2015
• Cholangiocarcinoma
  Nova Science Publishers 2015
• 核酸医薬開発の現状と展望
  飯田橋パピルス 2015
• 常在細菌叢が操るヒトの健康と疾患 高度外科侵襲手術における周術期シンバイティクス投与の有用性
  羊土社 2014
• The Current Scenario: Advanced Resectable Gallbladder Cancer, Diagnosis and Surgical Approach.
  Elsevier Clinical Advisory Board 2013

ｍore...

• Surgeon initiated basic science research for the mechanisms of biliary obstruction-induced liver injury.
  (24th World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists. 2014)
• The adverse effect of preoperative cholangitis on the outcome of portal vein embolization and subsequent major hepatectomy.
  (11th World Congress of International Hepato-Pancreato-Biliary Association. 2014)
• A predictive power of prothrombin time and serum total bilirubin for postoperative mortality after major hepatectomy with extrahepatic bile duct resection.
  (11th World Congress of International Hepato-Pancreato-Biliary Association. 2014)
• Surgical basic sciences for the treatment against hepato-biliary-pancreatic cancer. A research work conducted by active surgeons.
  (Seoul International Symposium of Surgical Oncology 2014 2014)
• Perioperative synbiotics treatment reduces postoperative bacteremia through suppression of bacterial translocation following highly invasive surgeries.
  (Seoul International Symposium of Surgical Oncology 2014 2014)

ｍore...

• 工学士
• Doctor of Medicine (Nagoya University)
• Ph.D. in Biology/Physiology (University of North Carolina at Charlotte)
• Doctor (Medicine) (Nagoya University)
• Bachelor of Mechanical Engineering
Ph.D. in Biology/Physiology (University of North Carolina at Charlotte)

• 2020/04/01 - 現在 Nagoya University Graduate School of Medicine Endowed Chairs Designated professor
• 2011/04/01 - 現在 Nagoya University Hospital, Hospital
• 2018/10/01 - 2020/03/31 Nagoya University Graduate School of Medicine Endowed Chairs Endowed chair professor
• 2011/04/01 - 2018/09/30 Nagoya University Nagoya University Hospital Gastroenterological Surgery 1 Lecturer
• 2009/10/01 - 2011/03/31 Nagoya University School of Medicine Endowed Chairs Endowed chair lecturer
2009/10/01 - Nagoya University Graduate School of Medicine
2007/04/01 - 2009/09/30 Nagoya University Nagoya University Hospital Gastroenterological Surgery 1 Assistant Professor
2005/10 - 2007/03/31 Nagoya University Graduate School of Medicine, Department of Surgery, Division of Surgical Oncology: Assistant Professor Nagoya University Hospital Gastroenterological Surgery 1 Assistant
2005/10 - Nagoya University Graduate School of Medicine, Department of Surgery, Division of Surgical Oncology: Assistant Professor
2005/04 - 2005/09 Kasugai Municipal Hospital
2004/01 - 2005/03 Nagoya University Graduate School of Medicine, Department of Surgery, Division of Surgical Oncology
2002/09 - 2003/12 Aichi Saiseikai Hospital (Nagoya, Japan)
2001/07 - 2002/08 Postdoctoral research fellow (University of Alabama at Birmingham, Center of Surgical Research, Department of Surgery)
1998/04 - 2000/06 Adjunct Associate Researcher (University of North Carolina at Charlotte)
1998/01 - 1998/03 Nagoya University 1st Dept of Surg
1996/07 - 1997/12 Kiryu Kosei General Hospital (Gunma, Japan)
1993/04 - 1996/06 Ohgaki Municipa Hospital (Gifu, Japan)

International Association of Surgeons, Gastroenterologists and Oncologists ,  日本経腸静脈栄養学会 ,  日本外科代謝栄養学会 ,  Asian Pacific Hepato-Pancreto-Biliary Association (A-PHPBA) ,  International Association of Pancreatology (IAP) ,  The Japan Society of Hepatology ,  Surgical Infection Society ,  The American Association for the Study of Liver Diseases ,  International Hepato-Pancreato-Biliary Association (IHPBA) ,  The American College of Surgeons (FACS) ,  The American Physiological Society ,  Shock Society ,  Japan Society for Surgical Infection ,  Japanese Cancer Association ,  Japanese Biliary Association ,  Japan Pancreas Society ,  Japanese Society of Hepato-biliary -Pancreatic Surgery ,  Japanese Society for Endoscopic Surgery ,  The Japanese Society of Gastroenterology ,  Japan Surgical Association ,  Japanese Association for Acute Medicine ,  The Japanese Society of Gastroenterological Surgery ,  Japan Surgical Society